A5079552166- Biotin and Related Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Nutritional Studies and Diet
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Complement system in diseases
- Bone health and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Medical Imaging Techniques and Applications
- Immune responses and vaccinations
- Cancer-related gene regulation
- Health, psychology, and well-being
- NF-κB Signaling Pathways
- Maternal Mental Health During Pregnancy and Postpartum
- Mast cells and histamine
- Network Security and Intrusion Detection
- Pharmacological Effects and Assays
- Cancer, Lipids, and Metabolism
- Global Public Health Policies and Epidemiology
- Genetic Associations and Epidemiology
Beijing Information Science & Technology University
2025
Southeast University
2020-2023
Nanjing Medical University
2014-2023
Jilin University
2017-2020
Jiangsu Province Hospital
2014
Coronavirus disease 2019 (COVID-19) deteriorates suddenly primarily due to excessive inflammatory injury, and insulin-like growth factor-1 (IGF-1) is implicated in endocrine control of the immune system. However, effect IGF-1 levels on COVID-19 prognosis remains unknown. Using UK Biobank resource, we investigated association between circulating concentrations mortality risk (available death data updated 07 Sep 2020) among patients who had pre-diagnostic serum measurements at baseline...
Generalized Anxiety Disorder (GAD) is characterized by persistent, excessive worry about everyday situations, lasting for at least six months. Individuals with GAD often experience both psychological and physical symptoms, including restlessness, muscle tension, sleep disturbances. Freuds early idea of anxious expectation still a key part understanding the disorder, along more modern concepts free-floating anxiety panic attacks. Research into brain shows that tied to issues certain...
Abstract ADP-ribosylation-like factor 6 interacting protein 5 (Arl6ip5), which belongs to the prenylated rab-acceptor-family, has an important role in exocytic trafficking, glutathione metabolism and involves cancer progression. However, its expression pattern functional bone are unknown. Here we demonstrate that Arl6ip5 knock-out mice (Arl6ip5 Δ2/Δ2 ) show marked decrease of mineral density, trabecular volume thickness. Histomorphometric studies reveal formation parameters decreased but...
Objective Testosterone is a critical determinant of health in both genders. However, the relationship between circulating levels testosterone and mortality remains undetermined. Methods We examined associations serum total (TT) free (FT) with all-cause cause-specific 154 965 men 93 314 postmenopausal women from UK Biobank. Cox regression models were used to calculate hazard ratios (HR) 95% CIs. Given multiple testing, P < 0.005 was considered statistically significant. Results Over median...
Calcium plays a critical role in various physiological activities. However, the association between circulating calcium concentrations and mortality general healthy population remains undetermined.To examine of serum with all-cause cause-specific mortality.Leveraging data from UK Biobank (n = 361 662) US National Health Nutrition Examination Survey (NHANES, n 36 985), we prospectively examined using Cox proportional hazard restricted cubic spline models.During median follow-up 12.0 years,...
Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case-control studies for CRC, including 223 pairs US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial 190 prospective Chinese cohort. explored serum metabolites related body mass index (BMI), constructed metabolomic signature of obesity, examined association...
Background/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) closely related to schizophrenia. We investigated the association between C3 polymorphisms schizophrenia in Northeast Han Chinese population. Methods: A total of 2240 people, consisting 1086 patients with 1154 healthy controls, were recruited for this study. Ten single nucleotide (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, rs2250656) selected...
Recent research has shown that prenatal famine exposure may be one of the risk factors for schizophrenia and people born in years at an increased due to alteration DNA methylation genes. In this study, association rs2283291/rs4648635 incidence genetic level were investigated provide clues pathogenesis schizophrenia. A total 960 participants recruited, comprising 473 famine-exposed individuals (225 patients 248 controls) 487 non-famine-exposed (220 267 controls). The famine, schizophrenia,...
Abstract Background Coronavirus disease 2019 (COVID-19) deteriorates suddenly primarily due to excessive inflammatory injury, and insulin-like growth factor-1 (IGF-1) is implicated in endocrine control of the immune system. However, effect IGF-1 levels on COVID-19 prognosis remains unknown. Objective To investigate association between circulating concentrations mortality risk among patients. Design Prospective analysis. Setting UK Biobank. Participants 1425 patients who had pre-diagnostic...
The objective of this study was to detect the expression long noncoding RNA (lncRNA) colorectal cancer-associated lncRNA (CCAL) in osteosarcoma tissues and investigate its role angiogenesis potential molecular mechanisms associated with effect osteosarcoma.CCAL 40 noncancerous measured by qRT-PCR (quantitative real-time polymerase chain reaction). Tube formation assays were performed explore CCAL osteosarcoma. In addition, regulatory interaction between CCAL, miR-29b, ANGPTL4 investigated...
Background Schizophrenia (SCZ) is a complex and severe mental illness. There lack of effective biomarkers for SCZ diagnosis. The aim this study was to explore the possibility using serum peptides diagnosis as well analyze association variants in genes coding these SCZ. Methods After bead-based fractionation, matrix-assisted laser desorption ionization/time-of-flight mass spectrometry technique used identify that showed different expressions between 166 patients 201 healthy controls....
Background: Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from noncommunicable diseases. We aimed examine the longitudinal trajectories in risk factors, estimate their impact on CKD burden China 1991 2011, project trends next 20 years.
To investigate the relationship between polymorphism of related gene loci miRNAs regulated fibrinopeptide A and schizophrenia. Lay foundation for aetiology schizophrenia.Adapt to phase match sex age case-control study, a total 513 Chinese Han patients with schizophrenia were selected as case group, normal healthy persons control group. Obtaining SNPs information FGA by querying dbSNP database, reference HapMap database included site frequency screening. The distributions genotyped iMLDR® SNP...