A5035271950- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Iron-based superconductors research
- Neural dynamics and brain function
- RNA modifications and cancer
- Migraine and Headache Studies
- Blood Pressure and Hypertension Studies
- RNA Research and Splicing
- Inorganic Chemistry and Materials
- Nicotinic Acetylcholine Receptors Study
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Heart Rate Variability and Autonomic Control
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Ovarian function and disorders
- Vascular Malformations Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Autophagy in Disease and Therapy
- Renal and Vascular Pathologies
- Wnt/β-catenin signaling in development and cancer
- Synthesis and characterization of novel inorganic/organometallic compounds
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
Chongqing Medical University
2014-2025
Zhejiang University
2023-2025
Fudan University Shanghai Cancer Center
2024
Shanghai Medical College of Fudan University
2024
Shanghai Tongji Urban Planning and Design Institute
2024
Tongji University
2021-2024
Nanjing Medical University
2022-2024
The University of Texas Health Science Center at Houston
2021-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Abstract Dopamine signals mainly through D1 receptors (D1Rs) and D2 (D2Rs); D1R‐expressing or D2R‐expressing neurons contribute to distinct reward addictive behaviors. Traditionally, transgenic mice expressing green fluorescent protein (GFP) under D1R D2R promoters are used for verification in electrophysiology studies, whereas Cre employed behavioral research. However, it is unknown whether the same neuronal populations targeted GFP mice. Additionally, while D1Rs D2Rs known be expressed...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited treatment options, primarily due to the lack of hormone receptors and HER2 expression. Nano-based drug delivery systems, including PEGylated liposomes, polymeric nanoparticles, gold present promising strategy enhance therapeutic outcomes by improving solubility, targeting tumor cells more effectively, reducing systemic toxicity. These nanoparticles utilize both passive active mechanisms address TNBC’s resistance...
Abstract Background Pseudogene‐derived lncRNAs are widely dysregulated in cancer. Technological advancements have facilitated the functional characterization of increasing pseudogenes cancer progression. However, association between and RNA N6‐methyladenosine (m 6 A) modification cancer, as well underlying mechanisms, remains largely unexplored. Methods We analyzed expression 12 146 comprehensively examined m A RNAs derived from them their paralogs. Through integrative analysis multi‐omics...
Abstract Characterization of metabolic perturbation prior to hepatocellular carcinoma (HCC) may deepen the understanding causal pathways and identify novel biomarkers for early prevention. We conducted two 1:1 matched nested case‐control studies (108 55 pairs) examine association plasma metabolome (profiled using LC‐MS) with risk HCC based on prospective cohorts in China. Differential metabolites were identified by paired t tests orthogonal partial least‐squares discriminant analysis...
The posterior dorsomedial striatum (pDMS) is mainly composed of medium spiny neurons (MSNs) expressing either dopamine D1 receptors (D1Rs) or D2Rs. Activation these two MSN types produces opposing effects on addictive behaviors. However, it remains unclear whether pDMS D1-MSNs D2-MSNs receive afferent inputs from different brain regions the extrastriatal afferents express distinct receptors. To assess also contained D1Rs D2Rs, we generated double transgenic mice, in which D1R-expressing and...
Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms. The reinforcement of is mediated by the striatal direct-pathway medium spiny neurons (dMSNs) that project to substantia nigra pars reticulata (SNr). Cognitive flexibility cholinergic interneurons (CINs), which receive extensive inhibition. Here, we hypothesized increased dMSN activity induced inhibits CINs, reducing flexibility. We found cocaine administration in rodents caused long-lasting...
Electric stimulation has been proved to be available monitor the efficacy of renal denervation (RDN). This study was evaluate effectiveness high-frequency (HFS)-guided proximal RDN.A total 13 Chinese Kunming dogs were included and allocated RDN group (n=8) control (n=5). HFS (20 Hz, 8 V, pulse width 2 ms) performed from distal artery in all dogs. Radiofrequency ablations delivered only at positive sites where systolic blood pressure (BP) increased ≥10 mm Hg during HFS. Postablation over...
As cities progress into high-quality developments, the demand for urban parks that enhance residents’ well-being and sustainability is increasing. Traditional visual-centric design methods no longer suffice. Given vision hearing are primary sensory pathways through which people perceive their environment, exploring relationship with landscape experiences offers a novel perspective optimizing audiovisual perception quality of parks. This study explores between visual auditory elements to...
The dysregulated expression of glycolysis-related genes (GRGs) is closely related to the occurrence diverse tumors and regarded as a novel target tumor therapy. However, role GRGs in colon cancer unclear. We obtained 226 differential (DE-GRGs) from Cancer Genome Atlas (TCGA) database. Cox regression analysis was used construct DE-GRG prognostic model, including P4HA1, PMM2, PGM2, PPARGC1A, PPP2CB, STC2, ENO3, CHPF2. model could accurately predict overall survival rate TCGA GSE17536 patient...
Calcium plays a critical role in various physiological activities. However, the association between circulating calcium concentrations and mortality general healthy population remains undetermined.To examine of serum with all-cause cause-specific mortality.Leveraging data from UK Biobank (n = 361 662) US National Health Nutrition Examination Survey (NHANES, n 36 985), we prospectively examined using Cox proportional hazard restricted cubic spline models.During median follow-up 12.0 years,...
Exploration of new superconductors in multicomponent complex systems remains challenging. Among superconductors, those containing distinct superconducting layers are quite rare. In this work, based on the block-layer model together with formation energy calculations, we have designed and successfully synthesized a quinary intermetallic compound, Th2Mo2Ir2Si4C. The material crystallizes an intergrowth structure alternate stacking ThMo2Si2C ThIr2Si2 block along crystallographic c axis....
Excessive alcohol consumption is a known risk factor for stroke, but the effect of stroke on intake unknown. The dorsomedial striatum (DMS) and midbrain areas nigrostriatal circuit are critically associated to addiction. Here we sought explore influence uncover underlying mechanism. Rats were trained consume using two-bottle choice or operant self-administration procedure. Retrograde beads infused into DMS label specific neuronal types, ischemic was induced in dorsolateral (DLS). Slice...
Background Renal denervation (RDN) is used to manage blood pressure (BP) in patients with resistant hypertension (rHT), but effectiveness still a concern, and key arterial portion for successful RDN not clear. Objective The aim of this study was investigate the efficacy safety proximal versus full‐length renal artery ablation (rHT). Methods Forty‐seven rHT were randomly assigned receive ( n = 23) or 24) arteries. All lesions treated radiofrequency energy via saline‐irrigated catheter. Office...
Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case-control studies for CRC, including 223 pairs US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial 190 prospective Chinese cohort. explored serum metabolites related body mass index (BMI), constructed metabolomic signature of obesity, examined association...
Abstract Background Accumulating studies have shown that La‐related protein 1 (LARP1) is involved in the occurrence and development of various tumours. However, expression pattern biological role LARP1 hepatoblastoma (HB) remain unclear so far. Methods level HB adjacent normal liver tissues was analysed by qRT‐PCR, Western blotting immunohistochemistry assays. The prognostic significance evaluated Kaplan–Meier method multivariate Cox regression analysis. In vitro vivo functional assays were...
Introduction: Excessive activation of the sympathetic nervous system (SNS) and renin-angiotensin (RAS) are crucial interacted closely in pathogenesis chronic cardiovascular diseases. This study investigated effects renal denervation (RDN) on RAS. Materials methods: Eight Chinese Kunming dogs underwent bilateral RDN utilizing saline-irrigated radiofrequency ablation catheter. Blood pressure (BP) measurements, blood sampling assays angiography were performed at baseline, 30 min, one month...
Abstract Autonomic nervous system plays a crucial role in maintaining and regulating vessel tension. Renal denervation (RDN) may induce renal artery vasodilation by damaging sympathetic fibers. We conducted this animal study to evaluate whether could be direct indicator of successful RDN. Twenty-eight Chinese Kunming dogs were randomly assigned into three groups underwent RDN utilizing temperature-controlled catheter (group A, n = 11) or saline-irrigated B, sham procedure C, 6). angiography,...