A5101732214- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Renin-Angiotensin System Studies
- Diabetes Treatment and Management
- Migraine and Headache Studies
- Sodium Intake and Health
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Cardiac Imaging and Diagnostics
- Renal function and acid-base balance
- Heart rate and cardiovascular health
- Pulmonary Hypertension Research and Treatments
- Potassium and Related Disorders
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Calpain Protease Function and Regulation
- Advanced MRI Techniques and Applications
- Lymphatic System and Diseases
- Gout, Hyperuricemia, Uric Acid
- Redox biology and oxidative stress
- Educational Technology and Pedagogy
Dalian Medical University
2013-2024
Chongqing Medical University
2013-2024
Second Affiliated Hospital of Chongqing Medical University
2013-2024
Weifang People's Hospital
2024
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
Clinical Trial Investigators
2022
GTx (United States)
2018
Chinese University of Hong Kong
2015
University of Applied Sciences Landshut
2015
Abstract Objective We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-analysis using data from randomized controlled trials(RCTs). Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardioprotective effects via multiple mechanisms that may also contribute decrease risk. Methods searched in databases (PubMed, Embase, Cochrane Library, and clinicaltrials.gov) up April 2023. RCTs comparing with placebo were included. The atrial fibrillation(AF),...
Importance In patients with multivessel coronary artery disease (CAD) presenting ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared culprit lesion–only percutaneous intervention (PCI). Whether also improves angina-related health status is unknown. Objective To determine whether angina in STEMI and CAD. Design, Setting, Participants This secondary analysis of a randomized, multinational, open label trial patient-reported...
Electric stimulation has been proved to be available monitor the efficacy of renal denervation (RDN). This study was evaluate effectiveness high-frequency (HFS)-guided proximal RDN.A total 13 Chinese Kunming dogs were included and allocated RDN group (n=8) control (n=5). HFS (20 Hz, 8 V, pulse width 2 ms) performed from distal artery in all dogs. Radiofrequency ablations delivered only at positive sites where systolic blood pressure (BP) increased ≥10 mm Hg during HFS. Postablation over...
In cardiac fibroblasts, angiotensin II (Ang II) can increase connexin 43 (Cx43) expression and promote calmodulin-dependent protein kinase (CaMKII) activation. Cx43 overexpression is crucial for the fibroblast-myofibroblast transition. The main purpose of present study was to investigate role CaMKII in regulating determine whether CaMKII/Cx43 pathway essential controlling fibroblast activation differentiation. vivo, 4 weeks Ang infusion enhanced but reduced hearts undergoing fibrosis...
Angiotensin-(1-7) [ANG-(1-7)] mediates vasodilation, antiproliferation, anti-apoptosis and antifibrosis, therefore, it opposes the effects of angiotensin II (ANG II). However, detailed signal transduction mechanism following Mas receptor activated by ANG-(1-7) is still poorly understood. Src homology2-containing inositol phosphatase 1 (SHP-1), a redoxsensitive protein tyrosine phosphatase, negatively influences downstream signalling molecules, such as mitogen-activated kinases (MAPKs),...
Abstract Background Renal denervation (RDN) was still performed without any intra-procedural method for nerve mapping. Whether renal stimulation (RNS) is an efficient way to identify autonomic innervation and optimize the strategy RDN remain be worthy further exploration. Methods The characteristics of at sites with different blood pressure (BP) responses RNS were explored. Then, dogs anatomically eligible randomly assigned into elevated BP response ablation group, reduced RNS-control group....
Atrial fibrosis is an important factor in initiating and maintaining atrial fibrillation. The purpose of this study was to test the hypothesis that angiotensin-converting enzyme-2 (ACE2) overexpression might inhibit collagen accumulation improve remodeling a canine pacing model.Thirty-two mongrel dogs both genders were divided randomly into 4 groups: sham-operated, control, gene therapy with adenovirus-enhanced green fluorescent protein (Ad-EGFP), Ad-ACE2. All Ad-EGFP, Ad-ACE2 groups paced...
Vascular reactivity is a surrogate marker for atherosclerosis and predictive of cardiovascular outcome. Non-cardiovascular surgery associated with perioperative complications in high-risk patients. To evaluate the impact non-cardiovascular on reactive hyperaemia arterial endothelial function to investigate relationships between dysfunction invasive (laparotomy) or minimally (laparoscopic) surgery, we prospectively evaluated 106 patients undergoing abdominal under general anaesthesia (71...
The aim of this study was to investigate whether renal sympathetic denervation (RSD) improves ventricular heart rate (HR) control in patients with persistent atrial fibrillation (AF).Twenty-one (aged 57.5 ± 10.2 years, 76.2% male) AF and hypertension underwent RSD completed 7-days follow-up evaluations, including 24-hour Holter monitoring (Holter), blood pressure (BP), ambulatory BP (ABPM). Patients were grouped into tertiles average HR at baseline recording for evaluation effects on...
Chromophobe renal cell carcinoma (CHRCC) is a rare subtype of cancer, accompanied by subcapsular hematoma (SRH) without history traumatic or hemorrhagic disease, which clinically rare. The reason for CHRCC with SRH may be caused tumor rupture vascular rupture. In the early stage, it often asymptomatic and can easily overlooked misdiagnosed, leading to delayed treatment serious consequences.
Previous studies showed that radiofrequency energy delivery of the renal artery could induce an immediate and substantial blood pressure (BP)-elevation response, which might be indicative increase in central sympathetic nervous activity.The current study was to investigate whether presence BP-elevation response can serve as a surrogate predict BP reduction following denervation (RDN).Data were collected on 67 patients undergoing RDN for drug-resistant hypertension. The application defined...
Abstract Pulmonary artery hypertension (PAH) is a chronic vascular disease defined by the elevation of pulmonary resistance and mean pressure, which arises due to remodelling. Prior research has already established link between autonomic nervous system (ANS) PAH. Therefore, rebalancing ANS offers promising approach for treatment The process involves two key aspects: inhibiting an overactive sympathetic fortifying impaired parasympathetic through pharmacological or interventional procedures....
To verify whether Ang-(1-7) produces an antagonistic effect on Ang II-mediated atrial remodeling. II–induced HL-1 cell model and a rat of remodeling were constructed intervened with II Ang-(1-7), AngII +Ang-(1-7), II+ c-Src specific inhibitor (SU6656), + SSG (SHP-1/2 inhibitor, stibogluconate), respectively. The systolic blood pressure the caudal artery was detected. And trial fibrosis detected by Picrosirius red staining Masson's trichrome staining. Expressions transforming growth factor-β...
Hypertension significantly increases the risk of cardiovascular events and it is associated with high rates disability mortality. a common cause cerebrovascular accidents, which severely affect patients’ quality life lifespan. Current treatment strategies for hypertension are based primarily on medication lifestyle interventions. The renal sympathetic nervous system plays an important role in pathogenesis hypertension, catheter-based denervation (RDN) has provided new concept hypertension....
<title>Abstract</title> <bold>Background:</bold><italic> </italic> Although the association of dietary nitrate intake and improved blood pressure cardiovascular outcomes has been confirmed in healthy individuals non-cardiovascular disease (CVD) population, it still remains uncertain whether protective effect inorganic significant hypertensive population. <bold>Methods:</bold> This study analyzed health data 5,989 participants based on National Health Nutrition Examination Survey (NHANES)...
Abstract Background Adding intensive low-density lipoprotein cholesterol (LDL-C) lowering treatments or colchicine to statins resulted in additional cardiovascular benefits. However, the relative efficacy and priority of these agents are unclear. Purpose We aimed compare effects supplementary on outcomes patients with atherosclerotic diseases (ASCVD) receiving statins. Methods performed a systematic review frequentist network meta-analysis randomized controlled trials. The primary endpoint...