A5011843009- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- 14-3-3 protein interactions
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Birth, Development, and Health
- Plant Molecular Biology Research
- Thyroid Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Circular RNAs in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Kinase Regulation and GTPase Signaling
- COVID-19 and Mental Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adolescent and Pediatric Healthcare
- Biotin and Related Studies
- Bone health and osteoporosis research
- Phosphodiesterase function and regulation
Jilin University
2016-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2025
Xiamen University
2025
Beijing National Laboratory for Molecular Sciences
2018-2025
Nanjing Forestry University
2023-2025
Wuhan Sixth Hospital
2020-2025
Jiangsu Provincial Center for Disease Control and Prevention
2025
Second Affiliated Hospital of Jilin University
2017-2024
Peking University
2018-2024
State Forestry and Grassland Administration
2024
The epitranscriptomic mark N 6-methyladenosine (m6A) can be written, read, and erased via the action of a complex network proteins. m6A binding proteins read marks transduce their downstream regulatory effects by altering RNA metabolic processes. characterization readers is an essential prerequisite for understanding roles in plants, but identities have been unclear. Here, we characterized YTH-domain family protein ECT2 as Arabidopsis thaliana reader whose function required normal trichome...
Abstract Background N 6 -methyladenosine (m A) mRNA modification is essential for mammalian and plant viability. The U6 m A methyltransferases in other species regulate S-adenosylmethionine (SAM) homeostasis through installing pre-mRNAs of SAM synthetases. However, methyltransferase has not been characterized Arabidopsis little known about its role regulating photomorphogenesis flowering. Results Here we characterize that FIONA1 an installs snRNA a small subset poly(A) + RNA. Disruption...
Abstract Background and Aims Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) health among the oldest-old (aged ≥80 years), as inverse relationship BMI with mortality was reported. This study to investigate causal associations BMI, waist circumference (WC), or both people China. Methods A total 5306 community-based (mean age 90.6 years) were enrolled Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998 2018. Genetic risk scores...
Abstract Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1) is believed to function as a tumor suppressor, while 2 (PIK3R2) driver. However, there no systematic pan-cancer analysis of them. The study comprehensively investigated the gene expression, genetic alteration, DNA methylation, and prognostic significance PIK3R1 PIK3R2 in 33 different tumors based on TIMER, GEPIA, UALCAN, HPA, cBioPortal, Kaplan–Meier Plotter database. results indicated that lowly expressed most highly tumors,...
There is evidence that body mass index (BMI) closely related to hyperlipidemia. This study aimed estimate the cross-sectional relationship between Body Mass Index and hyperlipidemia.We recruited 21,435 subjects (aged 18-79 years residing in Jilin province, China) using multistage stratified cluster random sampling method. Subjects were interviewed with a standardized questionnaire physically examined. We analyzed BMI hyperlipidemia.The prevalence of hyperlipidemia was 51.09% (52.04% male...
The p53 tumor suppressor gene is mutated or deleted in nearly half of human cancers. murine double minute 2 (Mdm2) and Mdmx represent two important cellular regulators p53. aim this study was to evaluate the abnormalities p53, Mdm2 genes archived breast We assessed genetic instability at using high resolution multi-color fluorescent situ hybridization (FISH) protocol detected expression status protein (TP53), MDMx MDM2 by immunohistochemistry 115 samples infiltrating ductal carcinomas with...
N6-methyladenosine (m6A) is essential for RNA metabolism in cells. The YTH domain, conserved the kingdom of Eukaryotes, acts as an m6A reader that binds m6A-containing RNA. In plants, domain involved plant hormone signaling, stress response regulation, stability, translation, and differentiation. However, little known about genes tea-oil tree, which can produce edible oil with high nutritional value. This study aims to identify characterize domains within tree (Camellia chekiangoleosa Hu)...
Lipid droplets (LDs) are dynamic organelles that participate in the regulation of lipid metabolism and cellular homeostasis inside cells. LD-associated proteins, also known as perilipins (PLINs), a family proteins found on surface LDs regulate metabolism, immunity, other functions. In silkworms, pébrine disease caused by infection microsporidian
N6-methyladenosine (m6A) is one of the most abundant chemical modifications on mRNA in eukaryotes. RNA-binding proteins containing YT521-B (YTH) domain play crucial roles post-transcriptional regulation plant growth, development, and stress response by reading m6A mark. However, YTH domain-containing protein family has not been studied a valuable medicinal tree such as Cinnamomum camphora (C. camphora) yet. In this study, we identified 10 genes C. camphora, located eight out 12 chromosomes....
Epigenetic changes may account for the doubled risk to develop schizophrenia in individuals exposed famine utero. We therefore investigated DNA methylation a unique sample of patients and healthy conceived during great China. Subsequently, we examined two case-control samples without exposure whole blood brain tissue. To shed light on causality relation between methylation, human fibroblasts nutritional deprivation. In famine-exposed patients, found significant hypermethylation dual...
Abstract STUDY QUESTION What is the true incidence of chromosomal mosaicism in embryos analyzed by preimplantation genetic testing (PGT) SUMMARY ANSWER The much lower than we usually surmise. WHAT IS KNOWN ALREADY In recent years, contemporary methods for chromosome analysis, along with biopsy more one cell, have given rise to an increased rate detection after aneuploidy. However, exorbitant represents a dilemma and imposes restrictions on application PGT treatment. Concern has been raised...
Here, a novel strategy for the preparation of ultra-stable gold nanoparticles was developed based on core-shell structure single-molecule micelles, which offered advantages such as convenience, rapid preparation, size control. These enable specific miRNA detection, facilitating precise screening tumor cells.