A5047241258- Air Quality and Health Impacts
- Health disparities and outcomes
- Heavy Metal Exposure and Toxicity
- Climate Change and Health Impacts
- Global Health Care Issues
- Frailty in Older Adults
- Fish Ecology and Management Studies
- Nutritional Studies and Diet
- Health and Well-being Studies
- Nutrition and Health in Aging
- Healthcare Systems and Public Health
- Hydrology and Watershed Management Studies
- Dementia and Cognitive Impairment Research
- Soil and Water Nutrient Dynamics
- Aquaculture Nutrition and Growth
- Heavy metals in environment
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Health and Risk Factors
- Urban Heat Island Mitigation
- Aquatic Ecosystems and Phytoplankton Dynamics
- Fish Biology and Ecology Studies
- Inflammasome and immune disorders
- Gastroesophageal reflux and treatments
- Membrane-based Ion Separation Techniques
Nanjing Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Chinese Center For Disease Control and Prevention
2006-2025
Shaoxing University
2025
Jiangsu Province Hospital
2025
Xuzhou Medical College
2022-2024
Second People’s Hospital of Huai’an
2022-2024
Huaian First People’s Hospital
2022-2024
Leiden University
2022-2024
Center for Disease Control
2019-2024
Abstract Background and Aims Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) health among the oldest-old (aged ≥80 years), as inverse relationship BMI with mortality was reported. This study to investigate causal associations BMI, waist circumference (WC), or both people China. Methods A total 5306 community-based (mean age 90.6 years) were enrolled Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998 2018. Genetic risk scores...
Air pollution and its adverse effects on public health remain a considerable problem in China, where policies have been implemented to improve the situation. We aimed estimate disease burden associated with particulate matter (PM)2·5 across China for 2020 2030 identify populations regions most at risk, quantify benefits of air quality improvement targets, determine effect population growth ageing this burden.In modelling study, we investigated premature deaths PM2·5 basis scenarios proposed...
Background: Research on the relationship between long-term exposure to particulate matter with aerodynamic diameter ≤2.5μm (PM2.5) and poor cognitive function is lacking in developing countries, especially highly polluted areas. Objectives: We evaluated associations of PM2.5 a diverse, national sample older adults China. Methods: This analysis included data 13,324 (5,879 who were 65–79 years age, 3,052 80–89 2,634 90–99 1,759 ≥100 age) normal at baseline from March 2002 September 2014,...
Globally, developed countries such as the United States, Canada, Germany, Korea, have carried out long-term and systematic biomonitoring programs for environmental chemicals in their populations. The China National Human Biomonitoring (CNHBM) was to document extent of human exposure a wide array chemicals, understand profiles, magnitude ongoing trends general Chinese population, establish national biorepository. CNHBM adopted three-stage sampling method obtain nationally representative...
Metals can be either toxic or essential to health, as they play different role in oxidative stress and metabolic homeostasis during the ageing process. Population-based biomonitoring have documented levels ranges concentrations among general population of 0–79 years age. In people aged 80 above, metals may risk profiles, thus need better studied. Our aim is investigate (arsenic, cadmium, lead mercury) (chromium, cobalt, molybdenum, manganese, nickel selenium) their diseases, nutritional...
Kawasaki disease (KD), an acute febrile systemic vasculitis in children, has become the leading cause of acquired heart developed countries. Recently, altered gut microbiota was found KD patients during phase. However, little is known about its characteristics and role pathogenesis KD. In our study, composition featured by reduction SCFAs-producing bacteria demonstrated mouse model. Next, probiotic Clostridium butyricum ( C. ) antibiotic cocktails were respectively employed to modulate...
The association between fine particular matter (PM2.5) and frailty is less studied, the national burden of PM2.5-related in China unknown.To explore PM2.5 exposure incident older adults, estimate corresponding disease burden.Chinese Longitudinal Healthy Longevity Survey from 1998 to 2014.Twenty-three provinces China.A total 25,047 participants aged ≥65-year-old.Cox proportional hazards models were performed evaluate adults. A method adapted Global Burden Disease Study was used calculate...
Abstract Background The aim of this study was to examine the trends in impairment regarding activities daily living (ADL), physical performance, and cognitive function among oldest-old (those aged 80 older) China between 1998 2014. Methods We used data on 34,297 individuals from seven waves Chinese Longitudinal Healthy Longevity Study. estimated age, period, cohort effects prevalence self-reported ADL impairment, tested performance using age–period–cohort model. Results Regarding ADL, were...
Nasopharyngeal carcinoma (NPC) is a malignant tumor caused by an infection of the epithelial cells nasopharynx, which highly metastatic and aggressive. Due to deep anatomical site atypical early symptoms, majority NPC patients are diagnosed at terminal stages. There growing evidence that microRNAs offer options for detection, accurate diagnosis, prediction malignancy treatment response. Therefore, purpose this article was identify predict prognosis with integrating biological information...
Abstract Cognitive impairment and dementia have long been recognized as growing public health threats. Studies found that air pollution is a potential risk factor for dementia, but the literature remains inconclusive. This study aimed to evaluate association between three major pollutants (i.e., PM 2.5 , O 3 NO 2 ) cognitive among Chinese elderly population. Study participants were selected from Longitudinal Health Longevity Survey (CLHLS) after 2005. We define Mini‐Mental‐State Exam (CMMSE)...
The activation of inflammasomes (NLRP3 and NLRP1) is central to the pathogenesis inflammatory bowel disease (IBD). Here we examined protective effects a thioredoxin-mimetic peptide CB13 (TXM-CB13), known for its antioxidative stress anti-inflammatory properties. We TXM-CB13 on dextran sulfate sodium (DSS)-induced colitis lipopolysaccharide (LPS)-induced NLRP3 inflammasome in RAW264.7 macrophages. appeared alleviate symptoms DSS-induced significantly suppress protein mRNA levels NLRP3, Mlck,...
Objective: To investigate the impact of peripheral blood prolymphocyte percentage on prognosis patients with chronic lymphocytic leukemia (CLL) . Methods: This study included 300 diagnosed CLL at Department Hematology Jiangsu Provincial People's Hospital from October 2011 to December 2020. The association between and other parameters was analyzed, optimal cutoff determined by X-tile analysis. Further survival analysis prognostic model construction were used validate predictive value...
Objective: To investigate the association between sleep duration and activity of daily living (ADL) in elderly aged 65 years older China. Methods: A total 11 247 subjects above were included Chinese Elderly Health Factors Tracking Survey from March 29, 2005 to April 8, 2019. Self-made questionnaire was used collect data population sociological characteristics, health status disease status. ADL assessed by basic activities living. The impairment Cox proportional risk regression model....
The increasing application of synthetic fertilizer has tripled nitrogen (N) inputs over the 20th century. N enrichment decreases water quality and threatens aquatic species such as fish through eutrophication toxicity. However, impacts on freshwater ecosystems are typically neglected in life cycle assessment (LCA). Due to variety environmental conditions compositions, response emissions differs among ecoregions, requiring a regionalized effect assessment. Our study tackled this issue by...
Inefficient global nutrient (i.e., phosphorus (P) and nitrogen (N)) management leads to an increase in delivery freshwater coastal ecosystems induces eutrophication these aquatic environments. This process threatens the various species inhabiting ecosystems. In this study, we developed regionalized characterization factors (CFs) for at 0.5 × 0.5-degree resolution, considering different fates direct emissions freshwater, diffuse emissions, increased erosion due agricultural land use. The CFs...
The growing and increasingly intensified agricultural sector exerts major pressures on the environment. Specifically, nitrogen (N) phosphorus (P) runoff can induce eutrophication in freshwater ecosystems. To formulate environmental strategies for controlling eutrophication, decision-makers commonly consider importance of pollutant contributors before developing sector-specific policies. These types science-based decisions benefit from nutrient models that quantify transport fate. However,...