A5012646079- Redox biology and oxidative stress
- Macrophage Migration Inhibitory Factor
- Heme Oxygenase-1 and Carbon Monoxide
- Exercise and Physiological Responses
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Inflammasome and immune disorders
- Skin Protection and Aging
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sulfur Compounds in Biology
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Recreation, Leisure, Wilderness Management
- Glutathione Transferases and Polymorphisms
- Cell Adhesion Molecules Research
- Viral Infections and Immunology Research
- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- Helicobacter pylori-related gastroenterology studies
- Advanced Glycation End Products research
- Sport and Mega-Event Impacts
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Viral gastroenteritis research and epidemiology
Shaoxing University
2017-2025
Zhejiang University
2020
Nippon Veterinary and Life Science University
2015
Biology of Infection
2015
Kyoto University
2015
The topics of serious leisure and subjective well-being have been discussed extensively in previous research. It is generally acknowledged that people prefer to experience deeper satisfaction happiness through participation leisure-time physical activities. However, it essential examine the relationship between an urban setting as well mediating effect satisfaction. Data were collected from 447 recreational runners at 2018 Wuxi International Marathon event China. study results showed was...
The activation of inflammasomes (NLRP3 and NLRP1) is central to the pathogenesis inflammatory bowel disease (IBD). Here we examined protective effects a thioredoxin-mimetic peptide CB13 (TXM-CB13), known for its antioxidative stress anti-inflammatory properties. We TXM-CB13 on dextran sulfate sodium (DSS)-induced colitis lipopolysaccharide (LPS)-induced NLRP3 inflammasome in RAW264.7 macrophages. appeared alleviate symptoms DSS-induced significantly suppress protein mRNA levels NLRP3, Mlck,...
Human thioredoxin-1 (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-. It has been demonstrated that systemic administration and transgenic overexpression of TRX ameliorate inflammation various animal models, but its anti-inflammatory mechanism not well characterized. We investigated effects topically applied recombinant human (rhTRX) murine irritant contact dermatitis (ICD) induced by croton oil. Topically rhTRX was distributed only skin tissues under...
Accumulating evidence indicates that oxidative stress is associated with inflammation, and the cellular redox status can determine sensitivity final outcome in response to inflammatory stimuli. To control balance, mammalian cells contain a variety of oxidoreductases belonging thioredoxin superfamily. The large number these enzymes suggests complex mechanism regulation mammals, but precise function each family member awaits further investigations.We generated mice deficient transmembrane...
Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism inducing TRX of GGA is still unknown. We investigated effects in a murine irritant contact dermatitis (ICD) model induced by croton oil. Both topical application oral administration production Nrf2 activation. ameliorated ear swelling, neutrophil infiltration, inhibited expression TNF-α, IL-1β,...
Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis with redox-active dithiol; it induced in response to various stress conditions (e.g. oxidative damage, infection/inflammation, metabolic dysfunction, irradiation and chemical exposure). In multiple studies, Trx1 has shown excellent anti-inflammatory immunomodulatory effects when used treat animal models human inflammatory disorders. This review focusses on the protective roles effect mechanisms relation allergic...
Chronic obstructive pulmonary disease (COPD) is a widespread respiratory disease. This study examines extracellular vesicles (EVs) and proteins contained in EVs COPD.
To determine whether thioredoxin (TRX)-1 can be used as a valid biomarker for oxidative stress in dogs. ANIMALS AND SAMPLES: 10 Beagles and Madin-Darby canine kidney cells.Madin-Darby cells were to verify antigen cross-reactivity between human anti-TRX-antibodies. Dogs assigned receive 21% or 100% O2 (5 dogs/group) via an artificial respirator during 3-hour period of isoflurane anesthesia (starting at 0 hours). Blood urine samples collected before (baseline) 6, 12, 24, 48 hours after...