A5101994239- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Mast cells and histamine
- Cytokine Signaling Pathways and Interactions
- Histiocytic Disorders and Treatments
- CAR-T cell therapy research
- Cardiac Ischemia and Reperfusion
- Contact Dermatitis and Allergies
- Tea Polyphenols and Effects
- Eosinophilic Disorders and Syndromes
- Cardiac Imaging and Diagnostics
- Phagocytosis and Immune Regulation
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Cutaneous lymphoproliferative disorders research
- Phytochemicals and Antioxidant Activities
- Autoimmune and Inflammatory Disorders
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Nail Diseases and Treatments
Tohoku University Hospital
2025
Kobe University
2014-2023
Tokyo Metropolitan Children's Medical Center
2017
National Center For Child Health and Development
2017
Ehime University
2005-2006
Asahi Breweries (Japan)
2004-2005
Gifu University
2004
Naga Municipal Hospital
1988
Okayama University
1984-1985
Nippon Medical School
1966-1977
Abstract Recent studies revealed that two novel interleukin (IL)-12-related cytokines, IL-23 and IL-27, have potent antitumor activities. However, the effects were mainly evaluated in relatively highly immunogenic tumors not been fully against nonimmunogenic or poorly tumors. In this study, we investigated efficacies of IL-27 on B16F10 melanoma found responses mediated by clearly different. syngeneic mice, mouse single-chain (sc) IL-23-transfected (B16/IL-23) exhibited almost same growth...
Abstract IL-27 is a member of the IL-6/IL-12 family and activates both STAT1 STAT3 through its receptor, which consists WSX-1 gp130. We previously demonstrated that has potent antitumor activities, are mediated CD8+ T cells, NK or own antiangiogenic activity. In this study, we demonstrate also possesses direct antiproliferative activity on melanoma. Although expression was hardly detected in parental mouse melanoma B16F10 activated up-regulated MHC class I transfectants expressing wild-type...
TAFRO syndrome is a unique clinicopathologic variant of multicentric Castleman's disease that has recently been identified in Japan. It characterized by constellation symptoms: Thrombocytopenia, Anasarca, reticulin Fibrosis the bone marrow, Renal dysfunction and Organomegaly (TAFRO). Previous reports have shown affected patients usually respond to immunosuppressive therapy, but sometimes fatal course. occurs middle-aged elderly there are no prior adolescents. Here we report first adolescent...
<h3>Importance</h3> Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target rapamycin, experience disfigurement skin lesions involving facial angiofibromas. Many have been left untreated because a lack therapeutic options are less invasive than surgery or laser treatment. <h3>Objective</h3> To confirm efficacy and safety sirolimus gel, 0.2%, for treatment angiofibromas and/or lesions. <h3>Design,...
Abstract: CD4 + CD25 T cells are an important population that plays a crucial role in the maintenance of peripheral self‐tolerance. Recently, it was shown elimination these by vivo administration anti‐CD25 monoclonal antibody (mAb) caused regression highly immunogenic tumors syngeneic mice. In this study, we examined whether B16F10 melanoma regressed with regulatory cells. We found were not affected at all mAb alone but tumor rejection resulted mice when combined IL‐12 gene transfer to ,...
Anti-tumor necrosis factor (TNF)-α therapy is used for the treatment of psoriasis, with varying outcomes. However, specific cause inadequate response or failure remains unknown. The aim present study was to identify useful clinical biomarkers predicting therapeutic responses serve as new drug targets refractory psoriasis cases. We performed a genome-wide association (GWAS) 65 patients who were prospectively followed after beginning anti-TNF-α using Human Omni Express-8 v1.2 Beadchips....
Transforming growth factor-beta-activated kinase 1 (TAK1) is a member of the mitogen-activated protein (MAP) family and an upstream signaling molecule nuclear factor-kappaB (NF-kappaB). Given that NF-kappaB regulates keratinocyte differentiation apoptosis, TAK1 may be essential for epidermal functions. To test this, we generated keratinocyte-specific TAK1-deficient mice from Map3k7(flox/flox) K5-Cre mice. The were macroscopically indistinguishable their littermates until postnatal day 2 or...
Background Current treatment with biologics has produced dramatic therapeutic effects in patients psoriasis, although these agents occasionally decrease efficacy. One of the main factors responsible for this attenuation is attributed to development antidrug antibodies (ADAs). Objectives To analyse relationship between serum drug concentrations, presence ADAs and efficacy adalimumab infliximab, determine optimal use biologics. Methods This was a 1-year prospective study dermatology...
Abstract Vitiligo is an acquired skin depigmentation disorder resulting from the selective loss of epidermal melanocytes, and previous studies have suggested that a T lymphocyte‐mediated mechanism has role in melanocyte loss. Although Fas‐Fas ligand (FasL) interactions are important for lymphocytes to mediate cytotoxicity, there only few reports examining involvement Fas‐FasL pathway vitiligo using vivo mouse models. In addition, been no concerning Fas‐mediated apoptosis human melanocytes...
Interleukin (IL)-27 is a member of the IL-6/IL-12 cytokine family and possesses potent antitumor activity, which mediated by multiple mechanisms. Toll-like receptor (TLR)3 critical sensor innate immune system that serves to identify viral double-stranded RNA. TLR3 frequently expressed various types malignant cells, recent studies reported synthetic agonist, polyinosinic-polycytidylic acid [poly(I:C)], induces effects on cells. In present study, we have explored effect IL-27 human melanomas...
Our previous clinical studies have demonstrated the short-term efficacy and safety of sirolimus gel for patients with tuberous sclerosis complex (TSC). However, long-term evidence is lacking. objective was to assess treatment skin lesions TSC patients. We conducted a multicenter, open-label, uncontrolled trial in 94 Japanese TSC. Patients applied 0.2% on their face or head twice daily > 52 weeks (maximum 136 safety). The endpoints were rate adverse event (AE)-caused discontinuation (primary...
ABSTRACT Aims This study aimed to investigate the trends in pediatric inflammatory bowel diseases (IBD) management Japan over past decade. Methods We retrospectively analyzed data from Japan's nationwide database 2012 2022. Patients aged ≤ 15 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) were included. Trends use of biologics, capsule endoscopy, total parenteral nutrition (TPN), elemental diets, surgery, and granulocyte monocyte apheresis (GMA) examined using...
To investigate the mechanism of antitumor effect locally secreted interleukin-12 (IL-12), we introduced IL-12 p35 and p40 cDNAs into mouse B16 melanoma cells. gene-transfected (B16/IL12) showed marked retardation tumor growth when implanted subcutaneously syngeneic mice. In these mice, depletion not only Natural Killer (NK) cells but also CD8+ T diminished IL-12. Immunohistochemical analysis that NK macrophages accumulated more densely at center periphery B16/IL12 tumors than parental...
Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory family in which extracellular region interacts with its ligand, CD47. Recent studies have demonstrated that SHPS-1 plays an important role cell migration and adhesion. We demonstrate this study, using immunohistochemical flow cytometric analyses, murine Langerhans cells (LCs) express SHPS-1. Treatment mice ears 2,4-dinitro-1-fluorobenzene significantly reduced number...