A5051011191- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Neuroscience and Neural Engineering
- Animal Virus Infections Studies
- Connexins and lens biology
- Photoreceptor and optogenetics research
- T-cell and B-cell Immunology
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pituitary Gland Disorders and Treatments
- Connective Tissue Growth Factor Research
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
University of Southern California
2014-2023
Southern California Eye Institute
2016-2023
Southern California University for Professional Studies
1992-2022
European Brain Research Institute
2022
Cedars-Sinai Medical Center
2022
Macquarie University
2022
Keck Hospital of USC
1999-2019
College of Charleston
2019
Doheny Eye Institute
2006-2018
LAC+USC Medical Center
1992-2018
Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF. In lesions in MS, subacute sclerosing panencephalitis, TNF+ cells demonstrated. At lesion site staining is associated both astrocytes macrophages. These observations not made Alzheimer's disease or normal tissue. The TNF MS suggests a significant role cytokines immune response progression.
Alzheimer's disease is a dementing disorder of unknown cause in which there degeneration neuronal subpopulations the central nervous system. In postmortem studies, we found widespread axonal optic nerves 8 10 patients with disease. The retinas four were also examined histologically, and three had reduction number ganglion cells thickness nerve-fiber layer. There was no retinal neurofibrillary or amyloid angiopathy, are typically seen brains changes observed clearly distinguishable from...
Why some patients with seizures are successfully treated antiepileptic drugs (AEDs) and others prove medically intractable is not known. Inadequate intraparenchymal drug concentration a possible mechanism of resistance to AEDs. The multiple gene (MDR1) encodes P-glycoprotein, an energy-dependent efflux pump that exports planar hydrophobic molecules from the cell. If P-glycoprotein expressed in brain epilepsy AEDs exported by lower concentrations could contribute lack response such patients....
Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification at-risk populations for earlier, more effective intervention. AD patients exhibit a myriad retinal pathologies, including hallmark amyloid β-protein (Aβ) deposits.Burden, distribution, cellular layer, structure Aβ plaques were analyzed in flat mounts cross sections definite controls (n = 37). In proof-of-concept imaging trial 16), probe curcumin formulation was...
Implantation of a human embryonic stem cell–derived retinal pigment epithelial monolayer is feasible in subjects with advanced, dry age-related macular degeneration.
Frozen brain specimens from eight multiple sclerosis (MS) patients were examined for the presence of leukocytes and their cell products by using a panel monoclonal antibodies. The results presented here demonstrated that in MS lesion, there was marked accumulation HLA-Dr-positive (Ia-positive) cells. These Ia-positive cells identified as being glial fibrillary acidic protein positive double staining methods. Furthermore, lesion expressed interleukin 2 (IL 2) receptor, anti-TAC antibody....
To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised nude rats. Cells were transplanted as a suspension (CS) or polarized monolayer plated on parylene membrane (PM).Sixty-nine rats (38 male, 31 female) surgically implanted with CS (n = 33) PM 36). Cohort subsets killed at 1, 6, 12 months after surgery. Both ocular tissues systemic organs (brain, liver, kidneys, spleen, heart, lungs) fixed...
Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement also requires its life cycle)-derived RNAs activate P2X7 and the NLRP3 inflammasome to cause cell death of retinal pigment epithelium in geographic atrophy, a type age-related macular degeneration. We found NRTIs inhibit P2X7-mediated activation independent inhibition. Multiple approved clinically relevant prevented caspase-1 activation,...
Abstract Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown described in Alzheimer’s disease (AD) that can predict cognitive decline yet have never been studied retina. Recent reports using noninvasive retinal amyloid imaging, optical coherence tomography angiography, histological examinations support existence vascular-structural abnormalities β-protein (Aβ) deposits retinas AD...
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly early stages of functional impairment, how they relate to progression brain remain largely unknown. To better understand pathological features AD retina, we conducted an extensive histopathological biochemical investigation postmortem retina tissues from 86 human donors. Quantitative examination superior inferior temporal retinas...
Experimental allergic encephalomyelitis (EAE) was generated in SJL and B10.PL mice by using the synthetic myelin basic protein peptides. Inflammation brain spinal cord preceded clinical signs of disease. Infiltrating lymphocytes were predominantly Lyt1+ (CD5+), L3T4+ (CD4+) T cells, until day 18. After that, F4/80+ monocyte/macrophages outnumbered cells. Ia+ cells microglia, macrophages, endothelial but Ia not detectable on astrocytes this EAE model. appeared later disease than microglia...