A5017163529- Retinal Imaging and Analysis
- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Management and Research
- Diabetes and associated disorders
- Renin-Angiotensin System Studies
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Neurological Disorders and Treatments
- Nuclear Receptors and Signaling
- Pancreatic function and diabetes
- Intensive Care Unit Cognitive Disorders
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
Cedars-Sinai Medical Center
2019-2023
Ospedale Maria Vittoria
1978
Abstract Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown described in Alzheimer’s disease (AD) that can predict cognitive decline yet have never been studied retina. Recent reports using noninvasive retinal amyloid imaging, optical coherence tomography angiography, histological examinations support existence vascular-structural abnormalities β-protein (Aβ) deposits retinas AD...
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly early stages of functional impairment, how they relate to progression brain remain largely unknown. To better understand pathological features AD retina, we conducted an extensive histopathological biochemical investigation postmortem retina tissues from 86 human donors. Quantitative examination superior inferior temporal retinas...
Abstract Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral myelomonocytes (ACE10 model) substantially diminished Alzheimer’s-like disease in double-transgenic APPSWE/PS1ΔE9 (AD+) mice. In this study, we explored the impact selective transient on macrophage behaviour relative contribution bone marrow-derived ACE10 macrophages, but not microglia, attenuating progression. To end, two vivo approaches...
Abstract Despite growing evidence for the characteristic signs of Alzheimer's disease (AD) in neurosensory retina, our understanding retina–brain relationships, especially at advanced stages and response to therapy, is lacking. In transgenic models AD (APP SWE /PS1 ∆E9 ; ADtg mice), glatiramer acetate (GA) immunomodulation alleviates progression pre‐ early‐symptomatic stages. Here, we explored link between retinal cerebral AD‐related biomarkers, including GA immunization, cohorts old,...
Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding particularly evident among older individuals who have pre-existing impairment, most commonly characterized by varying degrees of cerebral amyloid-β accumulation, neuroinflammation, and blood-brain barrier dysfunction. We sought to test the hypothesis that short-term mechanical contributes neuropathology impairment (i) increasing accumulation in mice Alzheimer's disease pathology, (ii)...
Significance Statement Men with diabetes have higher incidence of renal disease and hypertension than premenopausal women diabetes. A mouse model investigated the mechanisms that predispose to salt-sensitive during Male, 34-week-old, diabetic mice display when exposed a high-salt diet, whereas females remain normotensive. Hypertension in males was associated greater inflammation no downregulation epithelial sodium channel (ENaC) compared females. Blocking prevented development salt...
Previously, we have identified characteristic signs of Alzheimer's disease (AD) in the retina, a developmental outgrowth brain, presented as amyloid β-protein (Aβ) deposits. We further demonstrated feasibility non-invasive detection deposits retina and similar reduction cerebral retinal Aβ plaques response to immunomodulation young-adult APPSWE/PS1ΔE9 (ADtg) mice. However, exact relationship between brain pathology effects GA old mice, argued better correspond clinical human disease, not...
The retina of patients with Alzheimer's disease (AD) display several abnormalities, including the presence Aβ deposits, tauopathy, and retinal ganglion cell (RGC) degeneration. Although inflammatory responses are tightly correlated AD brain pathology, processes in underexplored. Here, we study pathology amyloidosis, gliosis, analysis RGCs mild cognitively impaired (MCI) compared to age- sex- matched controls. We quantified amyloid beta (Aβ) load (4G8 12F4) as well macro- micro-gliosis...
Abstract Alzheimer’s disease (AD) pathologies were discovered in the easily accessible neurosensory retina. Yet, their specific nature, topographical distribution, and relationship with status remain undefined. Here, we histologically determined burden spatial distribution of amyloid β-protein (Aβ 42 ), intraneuronal scFvA13 + -Aβ species, macro- microgliosis, atrophy superior- inferior-temporal retinas human donors mild cognitive impairment (MCI) or AD versus normal cognition. MCI patients...
Vascular changes including cerebral amyloid angiopathy (CAA), reduced blood flow, pericyte loss and vascular platelet-derived growth factor receptor-β (PDGFRβ) deficiency have emerged as prominent features of Alzheimer's disease (AD). We previously identified the existence pathological hallmarks AD, β-protein (Aβ) plaques, along with intracellular Aβ deposits in neurosensory retina AD patients. Data suggest that certain retinal signs manifest early progression appear similar to those...
Characteristic signs of Alzheimer's disease (AD) are increasingly reported in the neurosensory retina human patients and animal models, however examination retino-cerebral relationship, especially at late stages response to therapy, is scarce. Transgenic models AD (APPSWE /PS1∆E9 ; ADtg mice) treated with glatiramer acetate (GA) immunomodulation showed alleviation pre- early-symptomatic stages. Here, we explored link between retinal cerebral AD-related biomarkers, including GA immunization,...