A5023277940- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Neurotoxicity Research
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Arrest and Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Sedative Agents
- Stroke Rehabilitation and Recovery
- Tryptophan and brain disorders
- Urinary Bladder and Prostate Research
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Retinal Imaging and Analysis
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Tracheal and airway disorders
- Autoimmune Neurological Disorders and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
Neurology, Inc
2016-2025
Cedars-Sinai Medical Center
2015-2024
The George Institute for Global Health
2023
Ottawa Hospital
2023
Université de Montréal
2023
Cornell University
2014-2016
Columbia University
2015-2016
Columbia University Irving Medical Center
2015-2016
Mount Sinai Health System
2015
Icahn School of Medicine at Mount Sinai
2015
Objective To create a multidimensional tool to prognosticate long‐term functional, cognitive, and quality of life outcomes after spontaneous subarachnoid hemorrhage (SAH) using data up 48 hours admission. Methods Data were prospectively collected for 1,619 consecutive patients enrolled in the SAH outcome project July 1996 March 2014. Linear models (LMs) applied identify factors associated with 1,526 complete data. Twelve‐month measured modified Rankin scale (mRS), Telephone Interview...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to improve early noninvasive diagnosis and treatment. Particularly relevant are vascular changes, which appear prominent brain pathogenesis could predict cognitive decline. Recently, we identified platelet-derived growth factor receptor beta (PDGFRβ) deficiency pericyte loss associated with Aβ deposition the neurosensory retina of mild cognitively impaired (MCI) AD patients. However, pathological mechanisms...
Abstract Recent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes animal models of acute lung injury. Tocilizumab, an IL-6 inhibitor, has shown reduced duration ventilator dependency mortality critically ill patients with COVID-19. In this study, we test hypothesis that tocilizumab is associated delirium/coma prevalence 253 were included study cohort, 69 group 184 historical control...
A case of hearing deficit following nitrous oxide anaesthesia is reported. The mechanism and time course oxide-induced intratympanic pressure changes are described contrasted with the effects non-nitrous anaesthesia. rate increase about 10 mm H20/min. possibility that may cause displacement tympanic membrane grafts both outwards inwards, or disrupt reconstructed middle ear conducting mechanism, raised again.
Mechanical ventilation is a known risk factor for delirium, cognitive impairment characterized by dysfunction of the frontal cortex and hippocampus. Although IL-6 upregulated in mechanical ventilation-induced lung injury (VILI) may contribute to it not whether inhibition systemic mitigates delirium-relevant neuropathology. To histologically define neuropathological effects an experimental VILI model, was simulated anesthetized adult mice using 35 cc/kg tidal volume model. There were two...
Urinary tract infection (UTI) is frequently implicated as a precipitant of delirium, which refers to an acute confusional state that associated with high mortality, increased length stay, and long-term cognitive decline. The pathogenesis delirium thought involve cytokine-mediated neuronal dysfunction the frontal cortex hippocampus. We hypothesized systemic IL-6 inhibition would mitigate delirium-like phenotypes in mouse model UTI.C57/BL6 mice were randomized either: (1) non-UTI control, (2)...
Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding particularly evident among older individuals who have pre-existing impairment, most commonly characterized by varying degrees of cerebral amyloid-β accumulation, neuroinflammation, and blood-brain barrier dysfunction. We sought to test the hypothesis that short-term mechanical contributes neuropathology impairment (i) increasing accumulation in mice Alzheimer's disease pathology, (ii)...
To resolve the controversy regarding carotid body blood flow, we used radioactive microsphere technique for determination of tissue flow. We also measured flow to several other tissues in cat. Blood experiments were performed on 13 cats that anesthetized, paralyzed, and mechanically ventilated with air. Different numbers differently labeled 9-, 15-, 25-micron microspheres injected via a catheter into left atrium. It was determined one injection 5 x 10(6) 15-micron appropriate Flows bodies...
There is significant heterogeneity in the reporting of outcome measures aneurysmal subarachnoid hemorrhage (aSAH) research. The modified Rankin scale (mRS) most commonly reported functional measure. mRS focuses on physical disability; however, many aSAH survivors experience sequalae other domains, and may therefore not capture outcomes important to survivors. objective this study was assess clinical relevance as a research measure people with lived experience.We conducted an international...
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life those who survive acute illness. The mechanisms underlying these are not yet well understood, evidence-based interventions to minimize burden on patients remain unproven. National Heart, Lung, Blood Institute (NHLBI) Institutes Health assembled a workshop April 2023 review state science regarding ARDS-associated dysfunction, identify...