A5022920924- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Protein Kinase Regulation and GTPase Signaling
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Cardiac Arrest and Resuscitation
- Advanced Sensor Technologies Research
- Traumatic Brain Injury Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
- Analytical Chemistry and Sensors
- Pancreatic function and diabetes
- Intensive Care Unit Cognitive Disorders
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Health Systems, Economic Evaluations, Quality of Life
- Nuclear and radioactivity studies
- Acute Kidney Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Water Quality and Resources Studies
- Advanced Optical Sensing Technologies
- Fibroblast Growth Factor Research
- Ion channel regulation and function
Louisiana State University
2025
PSG INSTITUTE OF TECHNOLOGY AND APPLIED RESEARCH
2025
Louisiana State University Health Sciences Center Shreveport
2023-2024
Duke University
2014-2024
University of North Carolina at Chapel Hill
2012-2020
University of North Carolina Health Care
2017
Boston Medical Center
2017
Icahn School of Medicine at Mount Sinai
1998-2012
Medizinische Hochschule Hannover
2010
Johns Hopkins University
2006-2010
The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men prostate cancer and known atherosclerotic disease remains controversial.In this international, multicenter, prospective, randomized, open-label trial, concomitant were randomly assigned 1:1 to receive the antagonist degarelix or agonist leuprolide for 12 months. primary outcome was time first adjudicated major adverse event (composite death, myocardial infarction,...
The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated 150 Q4W in patients with inadequately controlled hypercholesterolemia and not on statin (majority statin-associated muscle symptoms), receiving treatment fenofibrate, ezetimibe, or diet alone.Patients were randomly assigned to placebo, 75 Q2W (calibrator arm), dose...
We used the yeast two-hybrid system to identify proteins that interact directly with Gα<sub>o</sub>. Mutant-activated Gα<sub>o</sub> was as bait screen a cDNA library from chick dorsal root ganglion neurons. found interacted several including Gz-GTPase-activating protein (Gz-GAP), new RGS (RGS-17), novel of unknown function (IP6), and Rap1GAP. This study focuses on Rap1GAP, which selectively interacts Gα<sub>o</sub>and Gα<sub>i</sub> but not Gα<sub>s</sub> or Gα<sub>q</sub>. Rap1GAP more...
The Gαo/i-coupled CB1 cannabionoid receptor induces neurite outgrowth in Neuro-2A cells. mechanisms of signaling through Gαo/i to induce were studied. expression reduces the stability its direct interactor protein, Rap1GAPII, by targeting it for ubiquitination and proteasomal degradation. This results activation Rap1. Gαo/i-induced endogenous Rap1 cells is blocked inhibitor lactacystin. stimulates that dominant negative Expression Rap1GAPII also blocks treatment with inhibitors potentiates...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Cellular senescence is an irreversible and multifaceted process inducing tissue dysfunction organismal aging, thus the clearance of senescent cells can prevent or delay onset aging-related pathologies. Herein, we developed augmented photothermal therapy strategy integrated with antibody against β2-microglobulin (aB2MG) immune adjuvant imiquimod (R837) to effectively accelerate cell apoptosis under a near-infrared light. With this strategy, designed CroR@aB2MG enables targeting application...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of Acrylodan-Labeled Bovine and Human Serum Albumin Entrapped in a Sol-Gel-Derived BiogelJeffrey D. Jordan, Richard A. Dunbar, Frank V. BrightCite this: Anal. Chem. 1995, 67, 14, 2436–2443Publication Date (Print):July 15, 1995Publication History Published online1 May 2002Published inissue 15 July 1995https://doi.org/10.1021/ac00110a019RIGHTS & PERMISSIONSArticle Views204Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the...
Background and Purpose- Predictors of stroke transient ischemic attack (TIA) in patients with peripheral artery disease (PAD) are poorly understood. The primary aims this analysis were to (1) determine the incidence ischemic/hemorrhagic TIA symptomatic PAD, (2) identify predictors (3) compare rate ticagrelor- clopidogrel-treated patients. Methods- EUCLID (Examining Use Ticagrelor Peripheral Artery Disease) randomized 13 885 PAD receive monotherapy ticagrelor or clopidogrel for prevention...
Abstract Background The purpose of this study was to examine the impact ARC on levetiracetam concentrations during first week following acute TBI. hypothesis are significantly lower in TBI patients with augmented renal clearance (ARC) compared those normal clearance. Methods This is a prospective cohort pharmacokinetic adults moderate severe treated after injury. Serial blood collections were performed daily for analysis levetiracetam, cystatin C, and 12-hr creatinine (CrCl) determinations....
To evaluate enhanced renal clearance over time in patients with aneurysmal subarachnoid hemorrhage or intracerebral via measured creatinine and to compare calculated by the Cockcroft-Gault equation estimated glomerular filtration rate Modification of Diet Renal Diseases equation.Prospective, observational study.Neurosciences ICU a tertiary care academic medical center.Study participants had an admission diagnosis hemorrhage, expected neurosciences length stay greater than 48 hours, no...
Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore,...
Norepinephrine inhibits omega-conotoxin GVIA-sensitive presynaptic Ca2+ channels in chick dorsal root ganglion neurons through two pathways, one mediated by Go and the other Gi. These pathways desensitize at different rates. We have found that recombinant Galpha interacting protein (GAIP) regulators of G signaling (RGS)4 selectively accelerate rate desensitization Go- Gi-mediated respectively. Blockade endogenous RGS proteins using antibodies raised against RGS4 slows these a selective...
Stroke patients requiring decompressive craniectomy are at high risk of prolonged mechanical ventilation and ventilator-associated pneumonia (VAP). Tracheostomy placement may reduce the duration ventilation. Predicting which will require tracheostomy optimal timing remains a clinical challenge. In this study, authors compare key outcomes after early versus late develop useful pre-operative decision-making tool to predict post-operative dependence. We performed retrospective analysis...