A5060768208- Laser Applications in Dentistry and Medicine
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Photoreceptor and optogenetics research
- Hydrogen's biological and therapeutic effects
- Connexins and lens biology
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Spaceflight effects on biology
- Neurological Disorders and Treatments
- Medical and Biological Ozone Research
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Pain Management and Treatment
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Enzyme Production and Characterization
- Apelin-related biomedical research
Louisiana State University
2024-2025
Tianjin Medical University
2025
Louisiana State University Health Sciences Center Shreveport
2022-2024
Xuzhou Construction Machinery Group (China)
2023
Nanjing Medical University
2022
Xuzhou Medical College
2003-2022
Augusta University
2019-2021
Affiliated Hospital of Xuzhou Medical College
2003-2012
Ludwig-Maximilians-Universität München
2005
Max Planck Institute of Neurobiology
1994
Cyclic nucleotide-gated cation channels are essential in visual and olfactory signal transduction. An additional member of the cGMP-gated channel family, termed CNG-3, has been cloned from bovine kidney. Its deduced amino acid sequence is 60% 62% identical with CNG-channel proteins rod outer segment epithelium, respectively. Northern analysis sequences amplified by PCR showed that CNG-3 mRNA present testis, kidney, heart. Calcium permeated expressed presence extracellular Mg2+ Na+ at...
ABSTRACT Purpose This study aimed to examine the effects of treadmill training on anxious–depressive-like behaviors transgenic Alzheimer rats in early stage Alzheimer’s disease (AD) and provided evidence exercise alleviating fear-avoidance behavior deficits. Methods Male 2-month-old TgF344-AD wild-type were divided into ( n = 9), AD 8), + (Exe) groups 12). After 8 months exercise, passive avoidance test, Barnes maze task, novel object recognition location test used measure learning memory...
Rationale: The integrity and function of the blood-brain barrier (BBB) is compromised after stroke. current study was performed to examine potential beneficial effects underlying mechanisms repetitive transcranial magnetic stimulation (rTMS) on angiogenesis vascular protection, function, repair following stroke, which are largely unknown. Methods: Using a rat photothrombotic (PT) stroke model, continuous theta-burst rTMS administered once daily infarcted hemisphere for 5 min, beginning 3 h...
The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage (L-type) channels were compared. L-type barium currents measured in Chinese hamster ovary cells stably transfected with the alpha 1 subunit class Cb channel. T-type investigated human medullary thyroid carcinoma cells. Ba++ transient, at threshold potential -50 mV maximum -14 +/- 3.2 blocked by micromolar Ni++. T- current inactivated time constants 33.4 4.1 416 26 msec...
Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal death and long-term neurobehavioral deficits in children. Currently, the only treatment option available for HI therapeutic hypothermia. However, necessary specialized equipment, possible adverse side effects, limited effectiveness of this therapy creates an urgent need development new methods. Photobiomodulation (PBM) has been shown be neuroprotective against multiple brain disorders animal models, as...
The blood‑brain barrier (BBB) is critical for proper cerebral homeostasis and its dysfunction during ischemic stroke can result in significant neurological injury. major goal of the present study was to identify whether curcumin pretreatment possessed protective effects on BBB integrity 24 h acute brain To investigate curcumin, male Sprague‑Dawley rats were divided into multiple groups, including sham, middle artery occlusion/reperfusion (MCAO/R) vehicle pretreated MCAO/R groups. measured by...
Neonatal hypoxia-ischemia (HI) injury caused by oxygen deprivation is the most common cause of mortality and severe neurologic deficits in neonates. The present work evaluated preventative effect photobiomodulation (PBM) preconditioning, its underlying mechanism action on brain damage an HI model neonatal rats. According to optimal time response ATP levels samples removed from normal rats, a PBM preconditioning (PBM-P) regimen (808 nm CW laser, 1 cm
Rationale: Previous work has indicated that continuous theta-burst stimulation (cTBS), a modality of transcranial magnetic (TMS), may provide neuroprotection and improve neurological function after stroke by preserving the blood-brain barrier, altering glial polarization phenotypes, supporting peri-infarct angiogenesis.The present study was performed to examine whether cTBS, noninvasive neurostimulation technique, promotes neurogenesis in photothrombotic (PT) rat model contributes functional...
Numerous epidemiological studies have reported a link between low testosterone levels and an increased risk of cerebrovascular disease in men. However, there is ongoing controversy surrounding replacement therapy due to potential side effects. PBMT has been demonstrated improve function promote synthesis peripheral tissues. Despite this, the molecular mechanisms that could connect with vascular brain photothrombosis (PT)-induced stroke rats remain largely unknown.
Recent research suggests that photobiomodulation therapy (PBMT) positively impacts the vascular function associated with various cerebrovascular diseases. Nevertheless, specific mechanisms by which PBMT improves remain ambiguous. Since endothelial nitric oxide synthase (eNOS) is crucial in regulating following cerebral ischemia, we investigated whether eNOS a key element controlling and senescence of cells treatment. Both rat photothrombotic (PT) stroke vitro oxygen–glucose deprivation...
Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore,...
Sepsis-induced systemic inflammatory responses can often lead to brain dysfunction with impaired cognitive function and mobility, known as sepsis-associated encephalopathy (SAE). Currently, there are no effective pharmacological therapeutics treat SAE. Herein, we demonstrated the hexapeptide functionalized gold nanoparticles P12 that reduced SAE in septic mice a dual mechanism down-regulate inflammation. We found intraperitoneally administered could target macrophages regulate their decrease...
A precise fear memory encoding a traumatic event enables an individual to avoid danger and identify safety. An impaired (contextual amnesia), however, puts the at risk of developing posttraumatic stress disorder (PTSD) due inability safe context when encountering trauma-associated cues later in life. Although it is gaining attention that contextual amnesia critical etiologic factor for PTSD, there no treatment currently available can reverse amnesia, whether such prevent development PTSD...
Delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) is the most severe and clinically intractable complication that occurs following CO poisoning. Unfortunately, mechanism of DEACMP still vague. Growing evidence indicates delayed cerebral damage related to oxidative stress, abnormal neuro-inflammation, apoptosis immune-mediated injury. Our recent report indicated methylene blue (MB) may be a promising therapeutic agent in prevention neuronal cell death cognitive...
Abstract Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy treat injury. Here, we examined PBM a repeated closed head (rCHI) rat model. Rats were administered total three injuries, with each separated by 5 days. treatment was initiated 2 hours after first daily for 15 We found that...
Abstract Maladaptive fear memory processing after a traumatic event is major contributor to the development of comorbidities related posttraumatic stress disorder (PTSD). An intervention normalize this process could be first-line treatment prevent PTSD development. However, little progress has been made in identifying interventions that can trauma survivors from developing PTSD. A help cope with memories and decrease prevalence thus high demand. This study was designed investigate potential...