A5018552172- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Intracranial Aneurysms: Treatment and Complications
- Pharmaceutical Practices and Patient Outcomes
- Innovations in Medical Education
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Antiplatelet Therapy and Cardiovascular Diseases
- Poisoning and overdose treatments
- Radiation Effects and Dosimetry
- Health Sciences Research and Education
- Cardiac, Anesthesia and Surgical Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Bacteriophages and microbial interactions
- Neurosurgical Procedures and Complications
- Pneumonia and Respiratory Infections
- Acute Kidney Injury Research
- Microbial Inactivation Methods
- Bacterial Identification and Susceptibility Testing
- Neuroscience and Neuropharmacology Research
University of Kentucky
2016-2025
University of Kentucky HealthCare
2015-2024
Albert B. Chandler Hospital
2004-2023
ProHealth Care
2023
Henry Ford Hospital
2019-2021
University of Tennessee at Knoxville
2019
Methodist University Hospital
2019
The Ohio State University Wexner Medical Center
2019
Brigham and Women's Hospital
2018
Harvard University
2018
To ascertain hospital inpatient mortality in England and to determine which factors best explain variation standardised death ratios.Weighted linear regression analysis of routinely collected data over four years, with ratios as the dependent variable.England.Eight million discharges from NHS hospitals when primary diagnosis was one diagnoses accounting for 80% deaths.Hospital predictors variations these ratios.The year crude rates varied across 3.4% 13.6% (average 8.5%), ranged 53 137 100)....
Background Acute treatment of cerebral edema and elevated intracranial pressure is a common issue in patients with neurological injury. Practical recommendations regarding selection monitoring therapies for initial management optimal efficacy safety are generally lacking. This guideline evaluates the role hyperosmolar agents (mannitol, HTS), corticosteroids, selected non-pharmacologic acute edema. Clinicians must be able to select appropriate based on available evidence while balancing...
Five anaerobic bacteria were tested for their abilities to transform tetrachloromethane so that information about enzymes involved in reductive dehalogenations of polychloromethanes could be obtained. Cultures the sulfate reducer Desulfobacterium autotrophicum transformed some 80 microM trichloromethane and a small amount dichloromethane 18 days under conditions heterotrophic growth. The acetogens Acetobacterium woodii Clostridium thermoaceticum fructose-salts glucose-salts media,...
PRELIMINARY REMARKS Guideline Limitations Practice guidelines should be used in the context of individual patient characteristics and may superseded by clinical judgment or preference. The use practice does not guarantee specific outcome benefit but rather serve as an evidence-based tool for clinicians. This guideline addresses commonly encountered antithrombotic-associated intracranial hemorrhage scenarios which data experience have been reported. Management patients with complex situations...
Neuroendovascular techniques for treating cerebral aneurysms and other cerebrovascular pathology are increasingly becoming the standard of care. Intraluminal stents, aneurysm coils, flow diversion devices typically require concomitant antiplatelet therapy to reduce thromboembolic complications. The variability inherent with pharmacodynamic response common agents such as aspirin clopidogrel complicates optimal selection by clinicians. This review serves discuss literature related use in...
Background: Since the approval of oral factor Xa inhibitors, there have been concerns regarding ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple guidelines suggest using prothrombin complex concentrates (PCCs) in these patients on basis research that includes a limited number with ICH. Given this, we aimed evaluate safety and efficacy PCCs for inhibitor–related ICH large, multicenter cohort patients. Methods: This was multicenter, retrospective,...
Mice deficient in small heterodimer partner (SHP) are protected from diet-induced hepatic steatosis resulting increased fatty acid oxidation and decreased lipogenesis. The lipogenesis appears to be a direct consequence of very low expression peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2), potent lipogenic transcription factor, the SHP−/− liver. current study focused on identification SHP-dependent regulatory cascade that controls PPAR-γ2 gene expression, thereby regulating fat...
Abstract Background The purpose of this study was to examine the impact ARC on levetiracetam concentrations during first week following acute TBI. hypothesis are significantly lower in TBI patients with augmented renal clearance (ARC) compared those normal clearance. Methods This is a prospective cohort pharmacokinetic adults moderate severe treated after injury. Serial blood collections were performed daily for analysis levetiracetam, cystatin C, and 12-hr creatinine (CrCl) determinations....
Summary. Maximum colony counts of unheated and heated spores Bacillus stearothermophilus were obtained after incubation at 50‐65°C 45‐50°C, respectively. the composition plating medium was found to have a marked effect upon recovery spores. effects diluent time on also been investigated.
Purpose. The purpose of this study was to compare the number and type medication errors reported before after implementation computerized prescriber order entry (CPOE); involvement a pharmacy resident in CPOE process will be described. Methods. neurosurgical intensive care unit (ICU) began on September 14, 2004. critical resident, faculty preceptor service, team, director were integral parts process. Protocols sets developed standardize frequent orders, expedite their entry, potentially...
Epilepsy affects up to 1% of the general population and causes substantial disability. The management seizures in patients with epilepsy relies heavily on antiepileptic drugs (AEDs). Phenobarbital, phenytoin, carbamazepine valproic acid have been primary medications used treat for several decades. Since 1993 AEDs approved by US FDA use epilepsy. choice AED is based primarily seizure type, spectrum clinical activity, side effect profile patient characteristics such as age, comorbidities...