A5015037794- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Aortic Disease and Treatment Approaches
- Acute Ischemic Stroke Management
- Ophthalmology and Eye Disorders
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Aortic aneurysm repair treatments
- Neurological Complications and Syndromes
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Spinal Hematomas and Complications
Centre Hospitalier de l’Université de Montréal
2016-2025
Université de Montréal
2014-2024
Université du Québec à Montréal
2002-2023
Hôpital Notre-Dame
2012-2022
Deleted Institution
2021
Canadian Sleep Society
2020
Canadian Thoracic Society
2020
Canadiana.org
2020
McGill University Health Centre
2017
Health Center
2017
The surgical treatment of basilar bifurcation aneurysms is difficult and the need for an alternative approach frequently stated. To assess efficacy safety endovascular located at bifurcation, authors prospectively studied angiographic results, clinical complications in 31 patients treated with Guglielmi detachable coils (GDCs). Patients acutely after subarachnoid hemorrhage (SAH) were graded according to Hunt Hess classification outcome was determined 1- 6-month intervals Glasgow Outcome...
<h3>Background</h3> Unruptured intracranial aneurysms (UIAs) are increasingly diagnosed and commonly treated using endovascular treatment or microsurgical clipping. The safety efficacy of treatments have not been compared in a randomised trial. How to treat patients with UIAs suitable for both options remains unknown. <h3>Methods</h3> We randomly allocated clipping coiling one more 3–25 mm judged treatable ways. primary outcome was failure, defined as: initial failure aneurysm treatment,...
Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with devastating consequences, including high mortality rate and severe disabilities among survivors. Inflammation induced following SAH, but the exact role phenotype of innate immune cells remain poorly characterized. We investigated inflammatory components early brain injury in an animal model SAH patients.SAH was through injection blood space C57Bl/6 J wild-type mice. Prospective collections were obtained at 12 h, days 1,...
<h3>BACKGROUND AND PURPOSE:</h3> Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety efficacy of 2 treatments a randomized trial. <h3>MATERIALS METHODS:</h3> Clipping or were randomly allocated to one more 3- 25-mm aneurysms judged treatable both ways by participating physicians. The study hypothesized that would decrease incidence failure from 13% 4%, composite primary outcome defined as aneurysm...
Many patients with ruptured intracranial aneurysms (RIAs) underrepresented or excluded from previous randomized controlled trials (RCTs) comparing surgery endovascular treatment (EVT) are still considered for surgical clipping, but the best management of these remains unknown. The International Subarachnoid Aneurysm Trial-2 was a trial versus EVT RIAs despite results RCTs, and also eligible EVT. primary endpoint death dependency according to modified Rankin Scale score (mRS > 2) at 1 year....
Up to 80% of patients report moderate severe pain after craniotomy. In this study, we assessed the efficacy scalp block for decreasing postoperative in brain surgery. Thirty scheduled supratentorial craniotomy were enrolled. They randomly divided into two groups: Ropivacaine (scalp with 20 mL ropivacaine 0.75%) and Saline saline 0.9%). Anesthesia was standardized. The performed skin closure before awakening. Postoperative at 4, 8, 12, 16, 20, 24, 48 h by using a 10-cm visual analog scale....
The objective of the study is to evaluate if rupture an aneurysm located on middle cerebral artery (MCA) results in disorders music recognition. To this aim, 20 patients having undergone brain surgery for clipping a unilateral left (LBS), right (RBS) or bilateral (BBS) aneurysm(s) MCA and neurologically intact control subjects (NC) were evaluated with series tests assessing most abilities involved In general, shows that ruptured repaired by very likely produce deficits auditory processing...
The management of unruptured brain arteriovenous malformation (AVM) patients remains controversial. Furthermore, curative attempts to treat ruptured AVM have not been questioned so far, and there is a lack prospective data on clinical results according treatment modality. Endovascular often used aiming improve the safety or efficacy surgery radiation therapy, but benefits never documented in trial. A care trial context needed evaluate interventions at same time they are practised. TOBAS...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Endoscopic third ventriculostomy (ETV) has become the first line of treatment in obstructive hydrocephalus. The Toronto group (Kulkarni et al.) developed ETV Success Score (ETVSS) to predict clinical response following based on age, previous shunt, and cause hydrocephalus a pediatric population. However, use ETVSS not been validated for population comprising adults. objective this study was validate "closed-skull" population, including patients 2 years age older.In retrospective...
Object The management of unruptured intracranial aneurysms remains controversial. goal this study was to evaluate the clinical community agreement in decision making regarding aneurysms. Methods A portfolio 41 cases with angiographic images, along a short description patient presentation, sent 28 clinicians (16 radiologists and 12 surgeons) varying years experience Five senior responded twice at least 3 months apart. Nineteen (46%) were selected from patients recruited Canadian UnRuptured...
OBJECT Blister aneurysms of the supraclinoid part internal carotid artery (ICA) are known for their high morbidity and mortality rates related to treatment, regardless whether treatment is surgical or endovascular. However, this grim prognosis based on results that indiscriminately group all blister together without taking into account heterogeneous appearance these lesions. The goal study was 2-fold: determine different aneurysm morphologies present pitfalls, which would then require...
Friedreich ataxia is a recessively inherited neurodegenerative disease caused by deficiency of highly conserved mitochondrial protein, frataxin. Frataxin results in iron accumulation and oxidative stress. shows homology with the CyaY proteins γ‐purple bacteria, whose function unknown. We knocked out gene Escherichia coli MM383 homologous recombination we generated an E. strain overexpressing . Bacterial growth, content survival after exposure to H 2 O did not differ among these strains,...
It was recently suggested that communicating hydrocephalus is an almost universal finding after hemicraniectomy and early cranioplasty may prevent the need for permanent cerebrospinal fluid diversion in these patients.To conduct a study attempt to verify findings.The medical records of all patients who underwent decompressive craniectomy medically refractory elevated intracranial pressure between 2001 2009 were retrospectively reviewed. Patients with subarachnoid hemorrhage, intraventricular...
Decompressive hemicraniectomy (DH) has been shown to reduce mortality in patients with malignant middle cerebral artery (MCA) territory infarction. However, many survive moderate-to-severe disability and controversy exists as whether this should be considered good outcome. To answer question, we assessed the quality of life (QoL) after DH for MCA infarction our milieu.The outcome all undergoing MCAterritory between 2001 2009 was using retrospective chart analysis telephone follow-up...