A5104490858- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic aneurysm repair treatments
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Aortic Disease and Treatment Approaches
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Meningioma and schwannoma management
- Cardiovascular and Diving-Related Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Oropharyngeal Anatomy and Pathologies
- Neurological Disorders and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Vascular anomalies and interventions
- Surgical Simulation and Training
- PI3K/AKT/mTOR signaling in cancer
- Trauma Management and Diagnosis
Lankenau Medical Center
2025
University of Calgary
2015-2024
Fluidigm (Canada)
2024
Deleted Institution
2003-2024
Foothills Medical Centre
2007-2023
Allen Institute for Brain Science
2017-2022
National Institutes of Health
2020
St. Michael's Hospital
2020
Neurosciences Institute
2020
Chinese University of Hong Kong
2020
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
<h3>BACKGROUND AND PURPOSE:</h3> Flow-diverting stents, such as the PED, have emerged a novel means of treating complex intracranial aneurysms. This retrospective analysis initial Canadian experience provides insight into technical challenges, clinical and radiographic outcomes, complication rates after use flow-diverting stents for unruptured <h3>MATERIALS METHODS:</h3> Cases were compiled from 7 centers between July 2008 December 2010. Each center prospectively tracked their experience;...
<h3>Background</h3> Unruptured intracranial aneurysms (UIAs) are increasingly diagnosed and commonly treated using endovascular treatment or microsurgical clipping. The safety efficacy of treatments have not been compared in a randomised trial. How to treat patients with UIAs suitable for both options remains unknown. <h3>Methods</h3> We randomly allocated clipping coiling one more 3–25 mm judged treatable ways. primary outcome was failure, defined as: initial failure aneurysm treatment,...
<h3>BACKGROUND AND PURPOSE:</h3> Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety efficacy of 2 treatments a randomized trial. <h3>MATERIALS METHODS:</h3> Clipping or were randomly allocated to one more 3- 25-mm aneurysms judged treatable both ways by participating physicians. The study hypothesized that would decrease incidence failure from 13% 4%, composite primary outcome defined as aneurysm...
NEUROSURGERY PUBLICATIONS OPERATIVE PRACTICE CNS.ORG
We review preliminary experience with patients harboring intracerebral hematoma (ICH) treated by stereotactic computed tomographic (CT) guided thrombolysis and aspiration assess procedure feasibility safety.Twelve supratentorial ICH >/=25 mL without suspected underlying structural etiology or coagulopathy an initial Glasgow Coma Scale (GCS) score of >/=5 were treated. A catheter was directed stereotactically manually into the through a burr hole under CT guidance. Hematoma followed...
OBJECTIVE: To examine the incidences of hypertension, hypotension, and bradycardia after carotid endarterectomy (CEA) to identify any hemodynamic variables predictive postoperative stroke, death, or cardiac complications. METHODS: Retrospective population-based cohort study 291 consecutive patients undergoing CEA using hospital chart review. Hemodynamic data collected from time arrival in recovery room until end 1st day. Primary secondary outcome events were stroke death within 30 days...
Background and Purpose— To address the increasing need to counsel patients about treatment indications for unruptured intracranial aneurysms (UIA), we endeavored develop a consensus on assessment of UIAs among group specialists from diverse fields involved in research UIAs. Methods— After composition group, Delphi was initiated identify rate all features, which may be relevant assess their by using ranking scales analysis inter-rater agreement (IRA) each factor. IRA categorized as very high,...
Background and Purpose— Human albumin has been shown to exert neuroprotective effects in animal models of cerebral ischemia humans with various intracranial pathologies. We investigated the safety tolerability 25% human patients subarachnoid hemorrhage. Methods— The Albumin Subarachnoid Hemorrhage (ALISAH) Pilot Clinical Trial was an open-label, dose-escalation study. intended study 4 different dosages increasing magnitude (0.625 g/kg: Tier 1; 1.25 2; 1.875 3; 2.5 4). Each dosage be given 20...
<h3>BACKGROUND AND PURPOSE:</h3> The PED is an FDS designed for the treatment of intracranial aneurysms. Data regarding use this device in acute or subacute aSAH limited to a few case reports small series. We aimed demonstrate feasibility using FDS, PED, ruptured aneurysms with challenging morphologies. <h3>MATERIALS METHODS:</h3> conducted retrospective review all known patients treated at 4 institutions between June 2008 and January 2012. Pertinent clinical radiologic information was...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Guided by the findings of randomized controlled trials evaluating carotid endarterectomy (CEA), we examined appropriateness CEAs performed in our city and determined incidences risk factors for postoperative stroke, death, cardiac complications.Using health records, retrospectively reviewed 291 consecutive region over 18 months. Based on trial results standardized remeasurements angiographic stenoses, indications CEA were considered appropriate symptomatic stenoses > or = 70%, uncertain <...
Introduction The SILK flow diverter (SFD) is used for the treatment of complex intracranial aneurysms. Small case series have been reported in literature but few studies with a large number patients published. We present our experience SFD aneurysms Canada. Methods Centers across Canada using SFDs were contacted to fill out report form treated an their center. Individual centers responsible approval from ethics committee. Image analysis was performed by individual operators. forms collected...
Background and Purpose- Intraluminal thrombus (ILT) is an uncommon finding among patients with ischemic stroke. We report clinical-imaging manifestations, treatment offered, outcome stroke/transient attack ILT in their cervico-cephalic arteries. Methods- Sixty-one of 3750 consecutive acute (within 24 hours onset) on initial arch-to-vertex computed tomography angiography from April 2015 through September 2017 constituted the prospective study cohort. Functional was assessed using modified...
OBJECTIVE Blunt cerebrovascular injury (BCVI) occurs in approximately 1% of the blunt trauma population and may lead to stroke death. Early vascular imaging asymptomatic patients at high risk having BCVI earlier diagnosis possible prevention. The objective this study was determine if implementation a formalized screening protocol with CT angiography (CTA) would improved detection METHODS Patients studies were identified from prospective registry single Level 1 center between 2002 2008....
Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps the highest likelihood embolization may have important implications. We evaluated safety by correlating findings procedural transcranial Doppler postprocedure diffusion-weighted imaging (DWI) lesions.In this prospective study, monitoring was performed during procedures, which were divided into 11 steps. Embolic signals on counted classified based relative...
The prevailing view amongst neurosurgeons is that the larger aneurysm, higher chance of rupture. This implies very small aneurysms rarely To investigate this theory, we conducted a cross-sectional hospital-based study aneurysmal subarachnoid hemorrhage, with an emphasis on aneurysm size at time We retrospectively reviewed hospital records and radiological tests all patients admitted to Foothills Medical Center, Calgary, Alberta, ruptured saccular from January 2008 2012. dome neck (in...
The advent of metal flow-diverting stents has provided neurointerventionalists with an option for treating aneurysms without requiring manipulations within the aneurysm sac. large amount in these stents, however, can lead to early and late thrombotic complications, thus requires long-term antiplatelet agents. Bioabsorbable have been postulated mitigate risk complications. Here we present data on first self-expandable primarily bioabsorbable stent aneurysms.Braided were developed using...
Background Stent-assisted coiling is a commonly adopted technique employed in the of broader-based aneurysms. It avoids flow arrest and risk vessel rupture associated with balloon-assisted coiling. However, there stent thrombosis corollary stroke during after procedure. Antiplatelet agents are used to mitigate this but raise secondary concern hemorrhagic complications, particularly ruptured aneurysm where further interventions such as ventriculostomy occur not infrequently. Stent removal...
Locally administered tissue plasminogen activator (TPA) accelerates clearance of intraventricular hemorrhage (IVH), but its impact on neurologic outcomes remains unclear and preclinical research suggests it may have pro-inflammatory effects. We randomly allocated patients with ruptured cerebral aneurysms IVH, treated endovascular coiling ventricular drainage, to receive either 2-mg TPA or placebo every 12 hours. Cerebrospinal fluid (CSF) serum cytokine white blood cell (WBC) concentrations...