A5034637646- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- CAR-T cell therapy research
- Meningioma and schwannoma management
- Monoclonal and Polyclonal Antibodies Research
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Pituitary Gland Disorders and Treatments
- Neurological Complications and Syndromes
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
Washington University in St. Louis
2016-2025
Neurological Surgery
2016-2025
University of Virginia Health System
2023
Hope Center for Neurological Disorders
2006-2021
University of Florida
2002-2021
University Radiology
2014-2021
University of Groningen
2021
Outcomes Research Consortium
2021
Engineering (Italy)
2021
Harborview Medical Center
2021
The brain is particularly vulnerable to ischemia. Complete interruption of blood flow the for only 5 minutes triggers death neurons in several regions, whereas 20–40 ischemia required kill cardiac myocytes or kidney cells. In part, prominent vulnerability tissue ischemic damage reflects its high metabolic rate. Although human represents about 2.5% body weight, it accounts 25% basal metabolism, a rate 3.5 times higher even than that brains other primate species. addition, central have...
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
To describe baseline clinical features and outcomes of adults with moyamoya phenomenon treated at a single North American institution.We identified 34 by review angiographic records. Clinical presentation stroke risk factors were obtained chart review. Follow-up was prospectively. A 5-year Kaplan-Meier calculated.The median age 42 (range 20 to 79) years. Twenty-five women. The initial symptom ischemia, hemorrhage, or asymptomatic in 24, 7, 3 patients, respectively. Twenty-two had bilateral...
The amyloid-β peptide (Aβ) plays a central pathophysiological role in Alzheimer's disease, but little is known about the concentration and dynamics of this secreted extracellular space human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples 18 patients who were undergoing invasive intracranial monitoring after acute injury. found strong positive correlation between changes ISF Aβ concentrations neurological status, with increasing as status...
Synaptic loss is an early pathologic substrate of Alzheimer disease (AD). Neurogranin a postsynaptic neuronal protein that has demonstrated utility as cerebrospinal fluid (CSF) marker synaptic in AD.To investigate the diagnostic and prognostic CSF neurogranin levels large, well-characterized cohort individuals with symptomatic AD cognitively normal controls.A cross-sectional longitudinal observational study cognitive decline patients controls was performed. Participants were clinical...
The ε4 allele of the apolipoprotein E (APOE) gene is strongest genetic risk factor for late-onset Alzheimer's disease (AD) and greatly influences development amyloid-β (Aβ) pathology. Our current study investigated potential therapeutic effects anti-human APOE antibody HAE-4, which selectively recognizes human that co-deposited with Aβ in cerebral amyloid angiopathy (CAA) parenchymal In addition, we tested whether HAE-4 provoked brain hemorrhages, a component amyloid-related imaging...
Cranial dural arteriovenous fistulae (dAVF) with cortical venous drainage (CVD) (Borden Types 2 and 3) are reported to carry a 15% annual risk of intracranial hemorrhage (ICH) or nonhemorrhagic neurological deficit (NHND). The purpose this study was compare the clinical course Type 3 dAVFs that present ICH NHND those do not.Twenty-eight patients were retrospectively evaluated. CVD classified as asymptomatic (aCVD) if presented incidentally pulsatile tinnitus orbital phenomena. symptomatic...
Atherosclerotic vertebrobasilar (VB) occlusive disease is a significant etiology of posterior circulation stroke, with regional hypoperfusion as an important potential contributor to stroke risk.To test the hypothesis that, among patients symptomatic VB stenosis or occlusion, those distal blood flow compromise measured by large-vessel quantitative magnetic resonance angiography (QMRA) are at higher risk subsequent stroke.A prospective, blinded, longitudinal cohort study was conducted 5...
Studies using the Nationwide Inpatient Sample (NIS), a large ICD-9-based (International Classification of Diseases, Ninth Revision) administrative database, to analyze aneurysmal subarachnoid hemorrhage (SAH) have been limited by an inability control for SAH severity and use unverified outcome measures. To address these limitations, authors developed validated surrogate marker severity, NIS-SAH Severity Score (NIS-SSS; akin Hunt Hess [HH] grade), dichotomous measure outcome, Outcome Measure...
Object The purpose of aneurysm surgery is complete obliteration while sparing associated arteries. Indocyanine green (ICG) videoangiography a new technique that allows for real-time evaluation blood flow in the and vessels. authors performed retrospective study to compare accuracy ICG with intraoperative angiography (IA), determine if can be used without follow-up IA. Methods From June 2007 through September 2009, 155 patients underwent craniotomies clipping aneurysms. Operative summaries,...
Indications for external beam radiation therapy (EBRT) atypical meningiomas (AMs) remain unclear.To analyze features associated with recurrence in AM patients after gross total resection (GTR) and to assess the relative benefit of EBRT a retrospective cohort study.One hundred fifty-one primary AMs GTR (88 female patients; median follow-up, 45.0 months) were examined possible predictors (age, sex, location, volume, bone involvement, brain invasion). The Fisher exact Wilcoxon rank-sum tests...
Significance One of the hallmarks Alzheimer’s disease (AD) is cerebral amyloid angiopathy (CAA), which a strong and independent risk factor for hemorrhage, ischemic stroke, dementia. However, mechanisms by CAA contributes to these conditions are poorly understood. Results from present study provide evidence that vascular oxidative stress plays causal role in CAA-induced cerebrovascular dysfunction, formation, itself. They also suggest NADPH oxidase source this strategies inhibit may have...
Highlights•CDC20-APC drives the invasiveness and self-renewal of glioblastoma stem-like cells•CDC20 is essential for in vivo tumorigenicity cells•CDC20-APC operates through SOX2 to control cell function•CDC20 prognostic overall survival Proneural subtype patientsSummaryGlioblastoma harbors a dynamic subpopulation cells (GSCs) that can propagate tumors resistant standard chemoradiation. Identification cell-intrinsic mechanisms governing this clinically important state may lead discovery...