A5031049033- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Medical Imaging and Analysis
- Urinary Tract Infections Management
- Pharmacological Effects and Toxicity Studies
- Anesthesia and Neurotoxicity Research
- Venous Thromboembolism Diagnosis and Management
- Herpesvirus Infections and Treatments
- Brain Metastases and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Hormonal and reproductive studies
- Cardiac Arrest and Resuscitation
- Bone and Joint Diseases
Cedars-Sinai Medical Center
2020-2024
Loma Linda University
2018
VA Greater Los Angeles Healthcare System
2013-2015
Mechanical ventilation is a known risk factor for delirium, cognitive impairment characterized by dysfunction of the frontal cortex and hippocampus. Although IL-6 upregulated in mechanical ventilation-induced lung injury (VILI) may contribute to it not whether inhibition systemic mitigates delirium-relevant neuropathology. To histologically define neuropathological effects an experimental VILI model, was simulated anesthetized adult mice using 35 cc/kg tidal volume model. There were two...
Abstract Objective Pharmacoresistance develops quickly during repetitive seizures, and refractory status epilepticus ( RSE ) remains a therapeutic challenge. The outcome of is poor, with high mortality morbidity. New treatments are needed. Deep hypothermia (20°C) used clinically reconstructive cardiac surgery neurosurgery, has proved safe effective in those indications. We tested the hypothesis that deep reduces its long‐term consequences. Methods model SE induced by lithium pilocarpine to...
Abstract Acute neuropsychiatric impairments occur in over 70% of patients with acute lung injury. Mechanical ventilation is a well-known precipitant injury and strongly associated the development delirium anxiety phenotypes. In prior studies, we demonstrated that IL-6 mediates neuropathological changes frontal cortex hippocampus animals mechanical ventilation-induced brain injury; however, effect systemic inhibition on structural functional phenotypes not known. We hypothesized murine model...
Nonhepatic hyperammonemia syndrome is a rare cause of neurologic dysfunction and cerebral edema has most commonly been reported in posttransplant patients. Only recently opportunistic infection with Ureaplasma species Mycoplasma hominis found to be key the pathogenesis. We describe cases 3 immunosuppressed patients who developed new-onset refractory status epilepticus diffuse edema. PCR was positive for M 1 patient parvum other 2. Despite early diagnostic suspicion aggressive management...
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Intrathecal methotrexate (IT MTX) resulting in severe adverse events including life-threatening cerebral edema is not well described. We report a rare case of death 37-year-old BRCA1+ woman with metastatic triple-negative breast cancer status post mastectomy following administration IT MTX for leptomeningeal carcinomatosis. Within the 24 hours after intraoperative delivery, she developed neurologically devastating diffuse leading to uncal and cerebellar tonsillar herniation. This highlights...
Urinary tract infections (UTIs) are common and frequently precipitate delirium-like states. Advanced age coincident with the postmenopausal period is a risk factor for delirium following UTIs. We previously demonstrated pathological role interleukin-6 (IL-6) in mediating phenotypes murine model of UTI. Estrogen has been implicated reducing peripheral IL-6 expression, but it unknown whether increased susceptibility females to developing concomitant UTIs reflects diminished effects circulating...
<h3>Objective:</h3> To share an intriguing case of a young transgender male patient receiving testosterone therapy who developed locked-in syndrome due to acute ischemic stroke and highlight potential risk factors for in the LGBTQI+ community <h3>Background:</h3> There are many studies identifying racially ethnically diverse populations. However, there is little existing data community. Prior research has shown cis-gender men with initially low levels increases stroke, especially first 2...
April 24, 2018April 10, 2018Free AccessImpact of Acute Interventions for Ischemic Strokes on Infarcted Tissue Volume: Comparison MRI Profiles (P3.203)Michael Gezalian, Jeremy Moretz, Walshe Izumigawa, Shauna Cheung, Brian Cristiano, Laura Nist, Bryan Tsao, Paul Jacobson, and Vincent TruongAuthors Info & AffiliationsApril 2018 issue90 (15_supplement) Letters to the Editor
Abstract Background: Prior published data show that short-term mechanical ventilation contributes to pathological hallmarks of Alzheimer’s Disease (AD) by increasing cerebral accumulation the amyloid-β 1-40 (Aβ ) peptide and neuroinflammation while unexpectedly decreasing blood-brain barrier permeability. In this study, we hypothesized acute immunochallenge promotes physiological emergence Aβ regions vascular disruption, resulting in reduced neuronal injury. Methods: Immunohistology was used...