A5011538774- Retinal Diseases and Treatments
- Ocular Oncology and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Lymphoma Diagnosis and Treatment
- Corneal Surgery and Treatments
- Connexins and lens biology
- Ocular Diseases and Behçet’s Syndrome
- CNS Lymphoma Diagnosis and Treatment
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Vascular Tumors and Angiosarcomas
- Systemic Lupus Erythematosus Research
- Cancer-related Molecular Pathways
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Viral-associated cancers and disorders
- Angiogenesis and VEGF in Cancer
- Advanced Glycation End Products research
- Corneal surgery and disorders
- Vascular Malformations Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Inflammatory mediators and NSAID effects
- Hedgehog Signaling Pathway Studies
Hokkaido University
2016-2025
Kaduna State University
2023
Ahmadu Bello University
2023
Creative Commons
2022
Teine Keijinkai Hospital
2014-2017
Doheny Eye Institute
2007-2016
University of Tartu
2015
University of Southern California
2008-2011
Ophthalmology Associates (United States)
2010
Keck Hospital of USC
2009
Background/Objectives: The aim of this study was to determine artificial intelligence-based macular fluid (MF) parameters in diabetic edema (DME) with optical coherence tomography (OCT) and examine stage-by-stage differences MF their relationship best-corrected visual acuity (BCVA). Methods: This enrolled 104 eyes treatment-naïve DME. Intraretinal (IRF) subretinal (SRF) were detected horizontal OCT images based on the “Hokkaido University segmentation model” when DME first observed together...
To compare the prediction accuracy of brachial-ankle pulse wave velocity (baPWV) from color fundus photographs (CFPs) using different deep learning models. This retrospective study analyzed data 696 participants whose baPWVs and CFPs were obtained during medical checkups. Arteriolar venular probability maps, which automatically calculated based on our modified U-net, Hokkaido University retinal vessel segmentation (HURVS) model, applied as channel attention to location information predict...
Aronia crude extract (ACE) with high levels of polyphenol compounds has been reported to have antioxidative effects in vitro and vivo. In this study, attention was focused on the antioxidant effect ACE. The purpose present study investigate ACE endotoxin-induced uveitis (EIU) rats. addition, expression inducible nitric oxide synthase (iNOS) cyclooxygenase (COX)-2 proteins investigated a mouse macrophage cell line (RAW 264.7) treated vitro, clarify anti-inflammatory effect.EIU induced male...
VEGFA and TGF-β are known major angiogenic fibrogenic factors. Galectin-1, encoded by lectin, galactoside-binding, soluble (LGALS)1, has attracted growing attention for its facilitatory role in angiogenesis fibrosis through modification of receptor signaling pathways. We reveal galectin-1 involvement the mouse model laser-induced choroidal neovascularization (CNV) subretinal fibrosis, both which represent pathogenesis age-related macular degeneration (AMD). Neither deletion nor...
The antiangiogenic and neurotrophic growth factor, pigment epithelial derived factor (PEDF), the proangiogenic vascular endothelial factor-A (VEGF), are released from retinal (RPE) cells where they play a critical role in pathogenesis of age-related macular degeneration (AMD). Since RPE polarity may be altered advanced AMD, we studied effect polarization differentiated, human monolayer cultures on expression secretion PEDF VEGF. Polarized demonstrated apical microvilli, tight junction...
Purpose: The aims of this study were to analyze optical coherence tomography (OCT) imaging large macular holes (MHs) treated with inverted internal limiting membrane (ILM) flap technique and perform a histological examination an ILM-like tissue obtained during vitrectomy. Patients methods: This is retrospective observational case study. Nine patients, comprising five males four females, showing myopic MHs, underwent pars plana vitrectomy (PPV) ILM assisted by brilliant blue G (BBG) staining....
Vascular endothelial growth factor (VEGF-A) is the principal stimulator of angiogenesis in wet age-related macular degeneration (AMD). However, VEGF-A generated by alternate splicing into two families, proangiogenic VEGF-A(xxx) family and antiangiogenic VEGF-A(xxx)b family. It that responsible for blood vessel seen AMD.To determine role isoforms as inhibitors choroidal neovascularization, authors used a model laser-induced neovascularization mouse eye investigated VEGF-A(165)b effects on...
To examine the expression of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)-2 in enucleated eyes with Coats' disease.Formalin-fixed, paraffin-embedded tissue sections from nine globes disease were submitted for hematoxylin eosin staining immunohistochemistry anti-VEGF VEGFR antibodies.Histologically, demonstrated presence macrophage infiltration cholesterol clefts subretinal space. There marked retinal abnormalities, including dilated vessels hyalinized vessel walls six...
Asymmetrical secretion of vascular endothelial growth factor (VEGF) by retinal pigment epithelial (RPE) cells in situ is critical for maintaining the homeostasis retina and choroid. VEGF also involved development progression age-related macular degeneration (AMD). We studied effect tumor necrosis factor-α (TNF-α) on polarized non-polarized RPE (P-RPE N-RPE cells, respectively) culture rats. A subretinal injection TNF-α caused a decrease expression choroidal atrophy. Porcine were seeded...
To measure central choroidal thickness (CCT) in patients with diabetic retinopathy (DR) and analyze the correlation clinical backgrounds regarding medications for diabetes mellitus (DM).We retrospectively identified 86 DR (172 eyes) 43 healthy subjects (57 who underwent spectral-domain optical coherence tomography. Among DM had received no intraocular treatments, 61 were continuously systemic treatments (under treatment group). Twenty-five discontinued or not any until this study started (no...
Vitreoretinal lymphoma (VRL) is a life- and sight-threatening disorder. The aim of this study was to analyze the usefulness cell block method for diagnosis VRL.Sixteen eyes in 12 patients with VRL, 4 idiopathic uveitis presenting vitreous opacity were enrolled study. Both undiluted diluted fluids isolated during micro-incision vitrectomy. Cell specimens prepared 19 from fluid containing shredding vitreous. These then submitted HE staining as well immunocytological analyses antibodies against...
Purpose To investigate the relationship between diabetic macular edema (DME) and choroidal layer thickness in patients. Methods This is a retrospective observation study. Three hundred eighteen eyes of 159 diabetes mellitus (DM) patients age-matched 100 79 healthy controls were enrolled. DME was defined as over 300 μm central retinal subfield Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector. The (CCT), well inner outer layers determined based on enhanced depth imaging...
To examine whether vasoproliferative retinal tumors (VPRTs) express vascular endothelial growth factor and respond to intravitreal bevacizumab injection.Retrospective interventional case series. Intravitreal 1.25 mg was administered 9 patients with VPRT-associated neovascularization or exudative changes. The changes of the tumor size, best-corrected visual acuity, central thickness were evaluated before after treatment. Immunohistochemistry anti-vascular antibody in an excised tissue VPRT...