A5082117193- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Contact Dermatitis and Allergies
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Herpesvirus Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Skin and Cellular Biology Research
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Cytomegalovirus and herpesvirus research
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Dermatological and Skeletal Disorders
- Allergic Rhinitis and Sensitization
- Advanced Glycation End Products research
- Cutaneous lymphoproliferative disorders research
- interferon and immune responses
- Genetic and rare skin diseases.
- Colorectal Cancer Treatments and Studies
Shikoku Cancer Center
2019-2025
Ehime University
2014-2023
Shinshu University
1993
Abstract The closure of skin wounds is essential for resistance against microbial pathogens, and keratinocyte migration an important step in wound healing. Cathelicidin hCAP18/LL-37 innate antimicrobial peptide that expressed the acts to eliminate pathogens. Because up-regulated at sites, we hypothesized LL-37 induces migration. In this study, found 1 μg/ml induced maximum level Boyden chamber assay. addition, phosphorylated epidermal growth factor receptor (EGFR) after 10 min, which...
Drug-induced hypersensitivity syndrome (DIHS) is an adverse reaction with clinical signs of fever, rash and internal organ involvement. In the vast majority patients in Japan, causative drugs for DIHS are limited to following eight: carbamazepine, phenytoin, phenobarbital, zonisamide, mexiletine, dapsone, salazosulfapyridine allopurinol. The association human herpesvirus (HHV)-6 reactivation has been reported by various groups.To confirm relationship between flaring severity HHV-6...
A severe adverse reaction to sulfasalazine therapy has been associated with hypersensitivity syndrome, the clinical features of which are similar infectious mononucleosis. No serologic evidence viral infections reported this syndrome; however, human herpesvirus 6 infection not specifically investigated, could cause an mononucleosislike syndrome.We report 2 cases syndrome induced by use sulfasalazine. The appeared 18 and 32 days after administration Clinical signs included a maculopapular...
Drug-induced hypersensitivity syndrome (DIHS) is characterized by a severe multiorgan reaction that usually appears after 3-6-week exposure to certain drugs, including anticonvulsants. There are some reports showing serum IgG levels often decrease at the early stage of DIHS. Reactivation human herpesvirus (HHV)-6 has been reported in patients with DIHS, and other DIHS showed reactivation cytomegalovirus (CMV) or Epstein-Barr virus (EBV).To determine whether HHV-6, HHV-7, CMV and/or EBV...
Abstract Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms ( DIHS / DRESS ) is a severe adverse drug caused by specific drug. It characterized visceral organ involvement reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution , little information available on sequelae in large patient population. The A sian Research Committee Severe Cutaneous Adverse Reactions,...
The role of angiotensin II (Ang II) in the control systemic blood pressure and volume homeostasis is well known has been extensively studied. Recently, Ang was suggested to also have a function skin wound healing. In present study, vivo healing investigated using type 1 receptor (AT1R) knock-out mice. Wound these mice found be markedly delayed. Keratinocytes fibroblasts play important roles healing, thus effect on migration cells examined. stimulated keratinocyte fibroblast dose-dependent...
IL-20 cytokine subfamily members, including IL-19, IL-20, and IL-24, are highly expressed in psoriatic skin lesions. Here, we demonstrate that psoriasis mediators IL-17 IL-22 synergistically induce the production of proteins cultured human keratinocytes. Interestingly, expression receptor (IL-22R) also increased epidermal lesions versus normal skin. IL-22R over-expression using an adenoviral vector to mimic conditions keratinocytes significantly enhanced IL-17- IL-22-induced cytokines....
Eccrine sweat is secreted onto the skin's surface and not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine contains a number of minerals, proteins, proteolytic enzymes, how it causes skin inflammation clear. We hypothesized that stimulates keratinocytes directly, as danger signal. was collected from arms healthy volunteers after exercise, levels proinflammatory cytokines were quantified by ELISA. detected presence IL-1α, IL-1β, high IL-31...
The epidermis is constantly exposed to a variety of microbial pathogens and plays vital role in resisting them. Soluble CXC chemokine ligand (CXCL) 16, which one the ELR− chemokines, acts as mediator innate immunity by attracting receptor (CXCR) 6-expressing cells, such activated T cells NKT cells. However, production CXCL16 non-immune remains unclear. We found that cultured keratinocytes produced significant amount (2–3 ng per 106 24 h). Stimulation with tumor necrosis factor α, IL-1α,...
Skin epidermis, in addition to its barrier function, is able actively sense harmful pathogens using pattern recognition receptors. In immune cells, the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome can mediate innate immunity against viral infection via a mechanism involving dsRNA recognition. Epidermal keratinocytes express NLRP3 inflammasome, which contact sensitizers mite allergens, leading pro-interleukin (IL)-1β...