A5015841731- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Contact Dermatitis and Allergies
- T-cell and B-cell Immunology
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Skin and Cellular Biology Research
- Stress Responses and Cortisol
- Autoimmune and Inflammatory Disorders
- Chronic Lymphocytic Leukemia Research
- Nail Diseases and Treatments
- Renal Diseases and Glomerulopathies
- Sarcoidosis and Beryllium Toxicity Research
- Transgenic Plants and Applications
Kyoto University
2016-2025
Agency for Science, Technology and Research
2024
Singapore Immunology Network
2024
A*STAR Graduate Academy
2024
National Institute of Allergy and Infectious Diseases
2020-2023
National Institutes of Health
2023
Kyoto University Hospital
2023
Government of the United States of America
2022
ActionAid
2017
Kyoto Pharmaceutical University
2000
The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial. This is due part to the use MC-deficient Kit W/Wv mouse model, since mice congenitally lack other types as a result point mutation c-kit. A recent study indicated that intronic enhancer (IE) for Il4 gene transcription essential MCs but not cell types. aim this re-evaluate roles CHS using which can be conditionally and specifically depleted. Transgenic Mas-TRECK are depleted were newly generated cell-type...
The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability induce polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for haptens peptide antigens, but not protein vivo. Consistent this, cannot take up or process ovalbumin significant quantities, present T differentiation via major histocompatibility...
Resolvin E1 (RvE1) is a lipid mediator derived from ω3 polyunsaturated fatty acids that exerts potent antiinflammatory roles in several murine models. The mechanism of RvE1 acquired immune responses has been attributed to attenuation cytokine production by dendritic cells (DCs). In this study, we newly investigated the effect on DC motility using two-photon microscopy contact hypersensitivity (CHS) model and found impaired skin. addition, attenuated T cell priming draining lymph nodes...
Significance Tissues exposed to the environment are sites of exposure symbiotic microbes including fungi that continuously sensed by immune system. Here, we show immunity commensal skin can significantly aggravate tissue inflammation. Enhanced pathology caused preexposure depends on lymphocytes able produce cytokine IL-17 and formation extracellular traps neutrophils. We also found fungal prior experimental modeling psoriasis recapitulates features transcriptional landscape human lesional...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous adverse drug reactions characterized by massive detachment. Cytotoxic T cells associated effector molecules known to drive SJS/TEN pathophysiology, but the contribution of innate immune responses is not well understood. We describe a mechanism which neutrophils triggered inflammation during early phases SJS/TEN. Skin-infiltrating CD8+ produced lipocalin-2 in drug-specific manner, formation...
Although nivolumab is associated with a significant improvement in overall survival and progression-free survival, only 20 to 40% of patients experience long-term benefit. It therefore great interest identify predictive marker clinical benefit for nivolumab. To address this issue, the frequencies CD4+ T cell subsets (Treg, Th1, Th2, Th9, Th17 Th22), CD8+ cells, serum cytokine levels (IFNγ, IL-4, IL-9, IL-10, TGF-β) were assessed 46 melanoma. Eighteen responded nivolumab, other 28 did not. An...