A5060264972- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- 3D IC and TSV technologies
- Radiomics and Machine Learning in Medical Imaging
- Electronic Packaging and Soldering Technologies
- Advanced Neuroimaging Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Fatigue and fracture mechanics
- Inflammatory Bowel Disease
- Numerical methods in engineering
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Hydrogen embrittlement and corrosion behaviors in metals
- Metal Forming Simulation Techniques
- Ovarian cancer diagnosis and treatment
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Atomic and Subatomic Physics Research
- Semiconductor materials and devices
- Fusion materials and technologies
- Endometriosis Research and Treatment
- Cell Adhesion Molecules Research
- Topic Modeling
Kyoto University
2016-2025
Saitama Medical University
2025
Shinko Hospital
2013-2024
Tokyo Metropolitan University
2024
Osaka Metropolitan University
2024
Inoue Hospital
2024
Weatherford College
2023
Dalle Molle Institute for Artificial Intelligence Research
2023
University of Zurich
2023
ETH Zurich
2023
Loss of intercellular adhesion and increased cell motility promote tumor invasion. In the present study, E- N-cadherin, members classical cadherin family, are investigated as inducers epithelial-to-mesenchymal transition (EMT) that is thought to play a fundamental role during early steps invasion metastasis carcinomas. Cell growth factors known regulate molecules. The purpose study presented here was investigate whether gain in N-cadherin pancreatic cancer involved process via EMT its...
Abstract The stromal cell-derived factor-1 (SDF-1)/CXCR4 system is implicated in various instances of cell migration mammals, including the lymphocytes and formation metastases. We have recently synthesized a potent novel CXCR4 antagonist, TN14003. purpose this study was to investigate role SDF-1/CXCR4 axis pancreatic cancer metastasis via invasion, inhibitory effect TN14003 on metastasis. expression detected six lines by Western blotting immunocytochemistry. In invasion assays, SDF-1...
Interleukin (IL)-10 is a potent regulatory cytokine that decreases inflammatory responses. This study investigated whether IL-10 levels in the airway are decreased chronic inflammation associated with asthma or obstructive pulmonary disease (COPD). Sputum was obtained from 12 healthy nonsmokers, 10 smokers, 16 asthmatic patients and seven COPD by means of sputum-induction method. The level measured via enzyme-linked immunosorbent assay immunocytochemical analysis. sputum significantly lower...
The widespread use of chest X-rays (CXRs), coupled with a shortage radiologists, has driven growing interest in automated CXR analysis and AI-assisted reporting. While existing vision-language models (VLMs) show promise specific tasks such as report generation or abnormality detection, they often lack support for interactive diagnostic capabilities. In this work we present RadVLM, compact, multitask conversational foundation model designed interpretation. To end, curate large-scale...
BACKGROUND Activation of matrix metalloproteinase-2 (MMP-2) has been implicated in the progression, invasion, and metastasis various cancers, but little information is available with regard to its role pancreatic carcinoma poor prognosis. METHODS Gelatin zymography was used for detection latent activated forms MMP-2 MMP-9 13 normal tissue specimens, 14 chronic pancreatitis 33 specimens. The gelatinase activity quantified by densitometer, 66-kilodalton (kDa)/(66-kDa + 72-kDa) ratio calculated...
Expression of several members the Bcl-2 family proteins was investigated by means both immunohistochemical analysis in 30 invasive ductal adenocarcinomas and 23 intraductal papillary-mucinous tumors (IPMTs) immunoblot 6 cancer tissues 7 pancreatic cell lines. We found that expressed 23%, Bax 53%, Bcl-X 90%, Mcl-1 90% adenocarcinomas. In adenocarcinomas, expression rate 44% those Bcl-XL were 88%; these values higher than for adenomas. Immunoblot identified as predominant form protein lines,...
Abstract Galectin-9 is a member of the galectin family and has been identified as an eosinophil chemoattractant produced by activated T lymphocytes. Vascular endothelial cells play important role in initial step recruitment activation immune inflammatory responses. We have addressed stimulation galectin-9 expression cells. was detected membrane cytosolic fractions human umbilical vein stimulated with interferon-γ (IFN-γ). IFN-γ also enhanced adhesion eosinophilic leukemia-1 to monolayers, it...
Introduction Overexpression of integrin αVβ3 had been demonstrated in various tumors. Studies have suggested that elevated levels melanoma cells are deeply involved the mechanism increased invasiveness. Aims To examine expression pancreatic carcinoma and to evaluate correlation between accompanied by MMP-2 activation clinicopathologic factors. Methodology Integrin specific antibody LM-609 was used for immunochemical analysis, intracellular localization determined human cancer cell lines...
To evaluate the potential of apparent diffusion coefficients (ADCs) obtained at quantitative diffusion-weighted magnetic resonance (MR) imaging breast as a biomarker low-grade ductal carcinoma in situ (DCIS).This retrospective study was approved by an institutional review board, and requirement to obtain informed consent waived. Twenty-two women (age range, 36-75 years; mean age, 56.4 years) with pure DCIS (seven DCIS, five intermediate-grade seven high-grade DCIS) three microinvasion...
Diffusion tensor imaging (DTI) and neurite orientation dispersion density (NODDI) are widely used models to infer microstructural features in the brain from diffusion-weighted MRI. Several studies have recently applied both increase sensitivity biological changes, however, it remains uncertain how these measures associated. Here we show that cortical distributions of DTI NODDI associated depending on choice b-value, a factor reflecting strength diffusion weighting gradient. We analyzed...
Abstract Purpose Neuromelanin-sensitive MRI (NM-MRI) has proven useful for diagnosing Parkinson’s disease (PD) by showing reduced signals in the substantia nigra (SN) and locus coeruleus (LC), but requires a long scan time. The aim of this study was to assess image quality diagnostic performance NM-MRI with shortened time using denoising approach deep learning-based reconstruction (dDLR). Materials methods We enrolled 22 healthy volunteers, non-PD patients PD who underwent NM-MRI, performed...
Natural language processing using models has yielded promising results in various fields. Language can help improve the workflow of radiologists. This retrospective study aimed to construct and evaluate for automatic summarization radiology reports. Two report datasets from MIMIC Chest X-ray (MIMIC-CXR) database Japan Medical Image Database (JMID) were included this study. The MIMIC-CXR is an open comprising chest radiograph JMID a large computed tomography magnetic resonance imaging reports...
Abstract Mammalian target of rapamycin (mTOR) is considered to be a major effector cell growth and proliferation that controls protein synthesis through large number downstream targets. We investigated the expression phosphatidylinositol 3′‐kinase (PI3K)/mTOR signaling pathway in human pancreatic cancer cells tissues, vivo antitumor effects mTOR inhibitor CCI‐779 with/without gemcitabine xenograft models cancer. found Akt, p70 S6 kinase (S6K1) from PI3K/mTOR were activated all lines...