A5016077083- Immune Response and Inflammation
- Malaria Research and Control
- Immune Cell Function and Interaction
- interferon and immune responses
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Complement system in diseases
- Hemoglobinopathies and Related Disorders
- Air Quality and Health Impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Travel-related health issues
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
Osaka University
2016-2025
The University of Tokyo
2019-2025
Japan Science and Technology Agency
2004-2024
Osaka International University
2008-2024
Suita Municipal Hospital
2015
Protein Research Foundation
2008
Harran University
2008
Ege University
2008
The University of Kitakyushu
2006-2007
Kyushu University
2006-2007
Malaria parasites within red blood cells digest host hemoglobin into a hydrophobic heme polymer, known as hemozoin (HZ), which is subsequently released the stream and then captured by concentrated in reticulo-endothelial system. Accumulating evidence suggests that HZ immunologically active, but molecular mechanism(s) through modulates innate immune system has not been elucidated. This work demonstrates purified from Plasmodium falciparum novel non-DNA ligand for Toll-like receptor (TLR)9....
IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses vivo. IPS-1–deficient mice showed severe defects both RIG-I– Mda5-mediated induction type interferon inflammatory cytokines were susceptible to virus infection. virus–induced regulatory factor-3 nuclear factor κB activation also...
Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a complex consisting adaptor MyD88, tumor necrosis factor (TNF) receptor-associated 6 (TRAF6) IFN regulatory (IRF) 7. Here we show an essential role IL-1 kinase (IRAK)-1 TLR7- TLR9-mediated IRF7 signaling pathway. IRAK-1 directly bound phosphorylated...
Abstract The innate immune system recognizes influenza A virus via TLR 7 or retinoic acid-inducible gene I in a cell-type specific manner vitro, however, physiological function(s) of the MyD88- interferon-β promoter stimulator 1 (IPS-1)-dependent signaling pathways antiviral responses vivo remain unclear. In this study, we show that although either IPS-1-signaling pathway was sufficient to control initial intranasal infection, mice lacking both failed responses, resulting increased viral...
Significance T-follicular regulatory (Tfr) cells, a subset of Foxp3-expressing T (Treg) have critical role in the control antibody responses. Whereas Treg cells express CD25 and are dependent on IL-2, Tfr also transcription factor BCL6 that is inhibited by IL-2 helper (Tfh) cells. In this report, we find mature germinal centers or circulating human blood down-regulate gain transcriptional signature mixed between Tfh while retaining their function. These represent an IL-2–independent branch...
Abstract Mature APCs play a key role in the induction of Ag-specific immunity. This work examines whether genomic DNA released by dying cells provides stimulus for APC maturation. Double-stranded but not single-stranded triggered to up-regulate expression MHC class I/II and various costimulatory molecules. Functionally, dsDNA enhanced function vitro improved primary cellular humoral immune responses vivo. These effects were dependent on length concentration independent nucleotide sequence....
Rare, circulating dendritic cells differentially shape the immunogenicity mechanisms for protection against H1N1 influenza.
Significance CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 ligand, is promising immunotherapeutic agent; however, developing an IFN-inducing ODN forming stable nanoparticle without aggregation has been unsuccessful. Here we generated nanoparticulate (K3) wrapped by the nonagonistic Dectin-1 ligand schizophyllan (SPG), K3-SPG. K3-SPG stimulates human peripheral blood mononuclear cells to produce large amounts of both type I and II IFN. thus became potent adjuvant, especially for...
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, reached phase III in lung cancer clinical trials. How effective against completely unknown. Here, we show that partial STING interfering with agonistic activation, which may explain its effect observed humans, as was reported to be pro-tumorigenic for cells low antigenicity. Furthermore,...
ABSTRACT Synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate an innate immune response characterized by the production of polyreactive immunoglobulin M antibodies and immunomodulatory cytokines. This has been shown to protect mice from challenge Listeria monocytogenes Francisella tularensis for up 2 weeks. By repeatedly administering ODN two four times/month, we found that this protection could be maintained indefinitely. Protection was associated with a...
Toll-like receptors (TLRs) recognize malaria parasites or their metabolites; however, physiological roles in infection vivo are not fully understood. Here, we show that myeloid differentiation primary response gene 88 (MyD88)-dependent TLR signaling mediates brain pathogenesis of severe infection, namely cerebral (CM). A significant number MyD88-, but TIR domain containing adaptor-inducing IFN-beta (TRIF)-deficient wild-type (WT) mice survived CM caused by Plasmodium berghei ANKA (PbA)...