A5103198421- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Surfactants and Colloidal Systems
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Polysaccharides and Plant Cell Walls
- Supramolecular Chemistry and Complexes
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Salivary Gland Tumors Diagnosis and Treatment
- Luminescence and Fluorescent Materials
- Block Copolymer Self-Assembly
- Electrostatics and Colloid Interactions
- Polymer Surface Interaction Studies
- Polymer crystallization and properties
- Tracheal and airway disorders
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Immune Response and Inflammation
- Biopolymer Synthesis and Applications
- Hydrogels: synthesis, properties, applications
- Polymer Nanocomposites and Properties
The University of Kitakyushu
2016-2025
Fujita Health University
2009-2023
University of Toyama
2021
Hudson Institute
2020
John Wiley & Sons (United States)
2020
Fukuoka University
2018-2020
Fujita Health University Okazaki Medical Center
2020
The University of Texas MD Anderson Cancer Center
2020
Arkansas Department of Agriculture
2020
RIKEN
2014-2019
Boronic acids can interact with Lewis bases to generate boronate anions, and they also bind diol units form cyclic esters. acid based receptor designs originated when Lorand Edwards used the pH drop observed upon addition of saccharides boronic determine their association constants. The inherent acidity is enhanced 1,2-, 1,3-, or 1,4-diols react esters (5, 6, 7 membered rings) in aqueous media, these interactions cornerstone diol-based receptors construction sensors separation systems.In...
We have found that single-chain schizophyllan and curdlan (s-SPG s-curdlan, respectively) can dissolve as-grown cut single-walled carbon nanotubes (ag-SWNTs c-SWNTs, in aqueous solution. The vis−NIR spectra of the composites suggest c-SWNTs are dissolved as a bundle, whereas ag-SWNTs exist one or only few pieces tubular hollow constructed by helical structure inherent to these β-1,3-glucans. EDX CLSM measurements TEM observation established distribution map polysaccharides overlaps well with...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMolecular Recognition of Adenine, Cytosine, and Uracil in a Single-Stranded RNA by Natural Polysaccharide: SchizophyllanKazuo Sakurai Seiji ShinkaiView Author Information Chemotransfiguration Project Japan Science Technology Corporation Kurume Research Center Building, 2432 Aikawa Kurume, Fukuoka 839-0861, Cite this: J. Am. Chem. Soc. 2000, 122, 18, 4520–4521Publication Date (Web):April 21, 2000Publication History Received3 January...
Supramolecular chiral insulated molecular wire was constructed by self-assembly of a neutral one-dimensional schizophyllan host and water-soluble polythiophene guest. The work presented here will not only open door to new application polysaccharides but also provide an important clue prepare stable supramolecular wires with one-handed helical structure.
Rare, circulating dendritic cells differentially shape the immunogenicity mechanisms for protection against H1N1 influenza.
Significance CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 ligand, is promising immunotherapeutic agent; however, developing an IFN-inducing ODN forming stable nanoparticle without aggregation has been unsuccessful. Here we generated nanoparticulate (K3) wrapped by the nonagonistic Dectin-1 ligand schizophyllan (SPG), K3-SPG. K3-SPG stimulates human peripheral blood mononuclear cells to produce large amounts of both type I and II IFN. thus became potent adjuvant, especially for...
Schizophyllan is an extracellular polysaccharide consisting of a β-1,3-d-glucan main chain and exists as triple helix in water single dimethyl sulfoxide (DMSO). When the schizophyllan (s-SPG) was mixed with poly(C), poly(A), poly(dA), or poly(dT), they form macromolecular complex. On other hand, poly(G), poly(U), poly(I), poly(dG), poly(dC) do not. This nucleotide specificity evidences that hydrogen bonds are essential to complex, because former nucleotides have unoccupied hydrogen-bonding...
Assemble a virus: A chemical strategy to de novo design "tailor-made" viruslike nanocapsules was developed (see picture). 24-mer β-annulus peptides of the tomato bushy stunt virus (TBSV) spontaneously self-assemble into hollow with size 30–50 nm. The structure assemblies clearly revealed by small-angle X-ray scattering (SAXS). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
An organogel system consisting of trans-(1S,2S)-bis(ureidododecyl)cyclohexane (SS-BUC) and a series primary alcohols was explored with optical polarizing microscopy (OPM), electron microscopy, circular dichroism (CD), wide-angle X-ray scattering (WAXS), synchrotron small-angle (SAXS). OPM, SAXS, especially WAXS showed that the gel fiber SS-BUC/methanol gels essentially consists SS-BUC crystal itself. SAXS in takes lamella domain spacing 5.2 nm. When we left at room temperature, decreased to...
β-1,3-Glucan polysaccharides have triple-stranded helical structures whose sense and pitch are comparable to those of polynucleotides. We recently revealed that the β-1,3-glucans could interact with certain polynucleotides form macromolecular complexes consisting two polysaccharide-strands one polynucleotide-strand. This unique property has made it possible utilize these as potential carriers for various functional In paticular, cell-uptake efficiency resultant polysaccharide/polynucleotide...
Summary The purpose of this study was to determine the viability Tongue Coating Index, which is a new method for evaluating tongue‐coating status. To reliability and reproducibility our evaluation criteria (Score 0: coating not visible; Score 1: thin, papillae tongue 2: very thick, visible), 10 observers evaluated 20 photographs tongues. Each surface divided into nine sections. Observers each section according score status recorded in pertinent Record form. They repeated same 2 weeks after...
We have developed a simple and robust fluorescence based boronic-acid molecular sensor for determining the concentration of fluoride in water at environmentally significant levels. The simplicity method ability to measure between 0.1 1.5 ppm is particularly noteworthy given WHO requirements detecting levels drinking below ppm.
New diazacrown-appended cholesterol gelators 1 and 2 were synthesized, their gelation ability was evaluated in organic solvents. Very surprisingly, + acetic acid gel results spherical vesicles with two distinct sizes 200 2500 nm diameter. In particular, the smaller are linked linearly, which is considered to serve as a driving-force for gelation. contrast, has multilayered tubular structure. To characterize aggregation modes phase, organogels observed by CD spectroscopy. The spectrum of...
We here demonstrate the creation of novel poly(aniline) (PANI) nanofiber structures by a polymer wrapping method using schizophyllan (SPG). Mannose-modified SPG can also wrap PANIs to give nanofibers having lectin affinity. This interaction is applicable designing PANI/protein composites. The results establish that act as "host" assemble into one-dimensional superstructures.
β-1,3-d-Glucans have been isolated from fungi as right-handed 61 triple helices. They are categorized by the side chains bound to main helix through β-(1→6)-d-glycosyl linkage. Indeed, since a glucose-based chain is water soluble, presence and frequency of give rise significant variation in physical properties glucan family. Curdlan has no self-assembles form an water-insoluble helical structure, while schizophyllan, which 1,6-d-glucose on every third glucose unit along chain, completely...
Synchrotron small-angle X-ray scattering (SAXS) at the SPring-8 40B2 and 45XU beamlines was carried out on aqueous solutions of (PEG-P(Asp(Bzl))): partially benzyl-esterified poly(ethylene glycol)-block-poly(aspartic acid) with LE540 loaded up to 8.3 wt %, where is a very hydrophobic retinoid antagonist drug. The profiles showed characteristic features for core−shell spherical micelles, confirming that P(Asp(Bzl)) forms core PEG hydrophilic shell. Before addition LE540, diffraction peak...
Antisense technologies for the targeted inhibition of gene expression could provide an effective strategy suppression inflammation. However, use antisense oligonucleotides (ODN) has been limited because several problems. Therefore, a delivery system ODNs that enhances stability, while maintaining specificity its target RNA or DNA is needed. We have developed ODN using schizophyllan (SPG), polysaccharide belongs to β-(1-3) glucan family. This advantages enabling DNA: SPG complex stable in...