A5085741536- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Mast cells and histamine
- Immunodeficiency and Autoimmune Disorders
- Pharmacovigilance and Adverse Drug Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eosinophilic Disorders and Syndromes
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- Pharmaceutical studies and practices
- Occupational exposure and asthma
- Nail Diseases and Treatments
- Skin Protection and Aging
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
- Caveolin-1 and cellular processes
Yokohama City University
2015-2024
Yokohama City University Hospital
2017
University of Crete
2016
Yokohama City University Medical Center
2001-2015
Juntendo University
2010
National Institute of Health Sciences
2008-2009
University of Yamanashi
2007
University Dermatology
2006
Stanford University
1989-1991
Stanford Medicine
1990
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 HLA-B*5801 with carbamazepine- allopurinol-induced reactions were found in Han Chinese patients, respectively, ethnic differences the have been reported. The objective this study is to clarify involvement Japanese SJS/TEN patients. Methods: HLA-B genotyping was performed on 58 patients between July 2006...
Summary Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B*1502 with carbamazepine‐induced SJS/TEN have been found in Han Chinese patients. These confirmed several Asian populations, excluding Japanese. SJS patients carrying HLA‐B*1508, HLA‐B*1511, or HLA‐B*1521, which members the HLA‐B75 type along HLA‐B*1502, were detected studies India Thailand. In current study, we...
Carbamazepine (CBZ) is frequently used for treating epilepsy, but this drug causes cutaneous adverse reactions (cADRs) that may range from mild to severe. It reported recently the human leukocyte antigen HLA-B*1502 associated with Stevens-Johnson syndrome (SJS) induced by CBZ in Han Chinese. We examined HLA class I 15 Japanese patients who fulfilled diagnostic criteria CBZ-induced cADRs (mild 10 and severe = SJS 5). HLA-B*1518, HLA-B*5901 HLA-C*0704 alleles showed higher relative risks...
Abstract Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms ( DIHS / DRESS ) is a severe adverse drug caused by specific drug. It characterized visceral organ involvement reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution , little information available on sequelae in large patient population. The A sian Research Committee Severe Cutaneous Adverse Reactions,...
Background Recent findings indicate that periostin, an extracellular matrix protein induced by T helper 2 cytokines, plays a critical role in the pathogenesis of atopic dermatitis (AD). Objectives To determine whether serum periostin level is associated with clinical phenotype adult patients AD. Methods An enzyme-linked immunosorbent assay was performed to levels 257 AD, 66 psoriasis vulgaris (PV) as disease control and 25 healthy controls. Serum were analysed together characteristics...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe adverse drug reactions with high mortality.To present the clinical characteristics of SJS TEN in Japan evaluate efficacy treatments, we retrospectively analyzed cases treated 2 university hospitals during 2000-2013.Fifty-two (21 males 31 females; average age, 55.1 years) 35 (17 18 56.6 were included this study. Twenty-eight (53.8%) all caused by drugs. Hepatitis was most common organ involvement both TEN....
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies medication related to SJS/TEN Asian populations. Thus, we analyzed registration databases from multiple countries who were treated during 1998–2017. A total 1,028 cases identified algorithm drug causality for necrolysis. Furthermore, those medications labeled...
Provocation tests in patients with food-dependent exercise-induced anaphylaxis (FDEIA) are often negative, even after a sufficient quantity of the implicated food and exercise have been taken.To investigate effect aspirin provocation skin prick testing (SPT) FDEIA. Gluten as major allergen wheat-dependent FDEIA was also investigated.Provocation SPT suspected foods were performed 12 combinations foods, aspirin. Detection gluten-specific IgE by CAP System FEIA radioallergosorbent test,...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions with high mortality.To present the current clinical characteristics treatment of SJS TEN in Japan, we retrospectively analyzed reports published medical journals from 2000 to 2006.Fifty-two cases (19 males 33 females; mean age, 45.2 years) 65 (31 34 45.7 were reported. Thirty-six (69.2%) all caused by drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, anticonvulsant...
Periostin, a matricellular protein, serves as regulator of wound healing and fibrosis. The role periostin in the pathogenesis systemic sclerosis (SSc) is unknown.To determine levels association with severity skin fibrosis patients SSc.Expression was immunohistochemically examined obtained from SSc healthy controls. Enzyme-linked immunosorbent assay performed to evaluate serum clinical characteristics 56 [diffuse cutaneous (dSSc), n=16; limited (lSSc), n=40] 66 controls.Periostin strongly...
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs (NSAIDs) multi-ingredient cold medications reported to be important inciting drugs. We used two sample sets Japanese patients investigate association between HLA genotypes medicine-related SJS/TEN (CM-SJS/TEN), acetaminophen-related (AR-SJS/TEN) with mucosal...
<b><i>Objectives:</i></b> Several studies on lactobacilli have demonstrated they are effective against atopic dermatitis (AD) in children, but there very few reports of their effects adults. We investigated the changes AD symptoms adults after ingestion <i>Lactobacillus acidophilus</i> strain L-92 (L-92), which has been shown to a curative effect children. <b><i>Methods:</i></b> A double-blind, parallel-group, placebo-controlled...
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker IPF. Our aim was use monomeric multicenter study evaluate its efficacy diagnosing predicting progression. To do so, we developed new kit detect only periostin. subjects consisted 60 patients cohort study. applied periostin, total detected by conventional...
Summary Drug-induced hypersensitivity syndrome (HS) is a rare but severe disease with multiorgan failure. Many different precipitating factors have been reported, the pathophysiology of HS remains unknown. However, association human herpesvirus (HHV) family, particularly HHV-6, has recently reported in patients HS. We report 14-year-old boy who was diagnosed as having carbamazepine-induced based on clinical course, laboratory data and results drug-induced lymphocyte stimulation tests. In...
Abstract Skin test reactions were evaluated in 242 patients who appeared to develop delayed type drug eruptions from the clinical course. The patch testing was positive 62 (31.5%) of 197 tested and intradermal 105 (89.7%) 117 patients. ratios higher maculopapular (MP), erythema multiforme (EM), erythrodermic (ED) types than eczematous (Ecz) eruptions, while those comparatively high ED, Ecz type, anticonvulsant‐induced eruptions. It is considered that combination useful for determination...