A5068441645- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Childhood Cancer Survivors' Quality of Life
- Pharmacovigilance and Adverse Drug Reactions
- Antiplatelet Therapy and Cardiovascular Diseases
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Pharmacology and Obesity Treatment
- Pharmaceutical studies and practices
- Oral and gingival health research
- Respiratory and Cough-Related Research
- Folate and B Vitamins Research
- Lipoproteins and Cardiovascular Health
- Food Allergy and Anaphylaxis Research
- Chronic Lymphocytic Leukemia Research
- Adenosine and Purinergic Signaling
- Venous Thromboembolism Diagnosis and Management
- Immune Cell Function and Interaction
- Medication Adherence and Compliance
Khon Kaen University
2015-2025
Vanderbilt University Medical Center
2020
PharmacoGenetics (China)
2016
Phenytoin is one of the most common causative drugs several types severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug with eosinophilia systemic symptoms (DRESS). Genetic polymorphisms human leukocyte antigens (HLA) cytochromes P450 (CYP) have been proposed key elements for susceptibility to phenytoin-related SCAR in certain ethnicities. This study investigated associations between genetic HLA class I CYP2C9 a Thai...
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies medication related to SJS/TEN Asian populations. Thus, we analyzed registration databases from multiple countries who were treated during 1998–2017. A total 1,028 cases identified algorithm drug causality for necrolysis. Furthermore, those medications labeled...
A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether valid prediction of reactions other ethnicities or nonleprosy patients. The aim this study to investigate an association between HLA genotypes and severe cutaneous adverse (SCARs) Thai patients.HLA-B 15 with SCARs (11 reaction eosinophilia systemic symptoms, 4 Stevens-Johnson...
Co‐trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case‐control study was conducted to investigate the involvement between genetic variants human leukocyte antigen ( HLA ) and CYP2C9 in CTX‐induced SCARs, including Stevens‐Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) drug reaction with eosinophilia systemic symptoms (DRESS) Thai patients. Thirty cases SCARs were enrolled compared 91 CTX‐tolerant controls 150 people from general...
HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite dapsone, believed to be responsible for DHS. However, studies have not highlighted importance other polymorphisms dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated association HLA alleles cytochrome P450 (CYP) with SCAR Thai patients. A prospective...
Introduction: Beta-lactam antibiotics are one of the most common causes antibiotics-related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP). Recent evidence demonstrated that human leukocyte antigen ( HLA ) polymorphisms play important roles in development drug-related SCARs. This study aimed to extensively characterize...
Allopurinol is one of the most common causes severe cutaneous adverse drug reactions (SCARs) including with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN). This study identified risk factors associated development allopurinol-induced SCARs in a Thai population.Eighty-six (i.e. 19 DRESS 67 SJS/TEN) 182 allopurinol-tolerant patients were enrolled study. The HLA-B*58:01 allele was determined. Clinical medicinal data collected.Results...
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction to medication that presents within 72 hours of exposure with erythematous papules and plaques overlying pustules. The immunopathogenesis predisposing factors AGEP are not well characterized. To better understand the genetic risk single-cell AGEP, we longitudinally characterized patient recurrent after an initial episode triggered by vancomycin. A clinical timeline over 8-year period was paired skin...
Severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and with eosinophilia systemic symptoms (DRESS) are potentially life-threatening caused by several drugs. Recently, a number of genes encoding for human antigen presenting proteins, HLA alleles, have been discovered as valid pharmacogenetic markers prediction these reactions. This study was aimed to determine the distribution alleles class I II in 183 unrelated...
HLA-B*13:01 -positive patients in Thailand can develop frequent co-trimoxazole hypersensitivity reactions. This study aimed to characterize drug-specific T cells from three hypersensitive presenting with either Stevens-Johnson syndrome or drug reaction eosinophilia and systemic symptoms. Two of the carried HLA allele interest, namely . Sulfamethoxazole nitroso sulfamethoxazole specific cell clones were generated lines patients. Clones characterized for antigen specificity cross-reactivity...
Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msup><mml:mrow/><mml:mrow><mml:mo>∗</mml:mo></mml:mrow></mml:msup></mml:math> 58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for id="M3"><mml:msup><mml:mrow/><mml:mrow><mml:mo>∗</mml:mo></mml:mrow></mml:msup></mml:math> before prescribing allopurinol in some populations has...
Carbamazepine (CBZ) is one of the most common causative drugs severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and with eosinophilia systemic symptoms. Although genetic polymorphisms human leucocyte antigens (HLA) are well recognized key elements for susceptibility to CBZ-induced SCARs, some evidence suggest that microsomal epoxide hydrolase 1 (EPHX1) may also contribute risk these SCARs. This study investigated...
Dapsone and co-trimoxazole are potent antibiotics for treating various infections inflammations. However, several studies reported the strongly association between severe cutaneous adverse drug reactions (SCARs) to both drugs HLA-B*13:01 allele. Rapid reliable screening allele can mitigate risk of dapsone-induced SCARs. We developed two methods, multiplex sequence-specific primer PCR (PCR-SSP) real-time (RT-PCR), tailored different clinical settings. These methods were optimized minimize...
Background The side effect of allopurinol was severe hypersensitivity (SAH). There are two major causes including genetic risk factor, HLA-B * 58:01 and non-genetic factors female, old age, renal impairment, inadequate starting dosage received diuretic. Although testing is recommended in Thai, the several problems cost, limitation delay result. Therefore, we aimed to use these for developing model predict SAH. Method study a retrospective observational incidence density sampling. SAH cases...
Studies found a strong association between HLA-B*13:01 allele and co-trimoxazole-induced severe cutaneous adverse reactions (SCARs). Genetic screening before initiation of co-trimoxazole may decrease the incidence SCARs. This study aims to evaluate cost-effectiveness in HIV-infected patients Thailand. A combination decision tree model Markov was used estimate lifetime costs outcomes two strategies including 1) 2) usual practice from societal perspective. Alternative drugs are not considered...
Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X-type motif 15 ( NUDT15 ) genes have been proposed as key determinants 6-mercaptopurine (6-MP)-induced myelosuppression in pediatric acute lymphoblastic leukemia (ALL). In the present study, genotypes TPMT were investigated 178 Thai patients with ALL by TaqMan SNP genotyping assay DNA sequencing. The frequency TPMT*3C was 0.034. Among variants, NUDT15*3 is most common variant allele...
Clopidogrel is a commonly used antiplatelet aggregation agent. Compared with the reference clopidogrel product, most commercially available generic products contain different crystalline forms of clopidogrel. This study was aimed to compare pharmacodynamics product in Thailand under steady state conditions.A multiple-dose, randomized 2-way crossover conducted 32 healthy male Thai volunteers. The subjects were assigned receive 75 mg once daily test or for 7 days 2-week wash out period. Blood...