A5088389913- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Pharmacogenetics and Drug Metabolism
- Urticaria and Related Conditions
- Pharmacovigilance and Adverse Drug Reactions
- Inflammatory mediators and NSAID effects
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Asthma and respiratory diseases
- Folate and B Vitamins Research
- Eicosanoids and Hypertension Pharmacology
- Hemoglobinopathies and Related Disorders
- Statistical Methods in Clinical Trials
- Mast cells and histamine
- Antibiotic Resistance in Bacteria
- Eosinophilic Disorders and Syndromes
- Antifungal resistance and susceptibility
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Methemoglobinemia and Tumor Lysis Syndrome
Ramathibodi Hospital
2020-2024
Mahidol University
2020-2024
Thammasat University
2021
University of Rajshahi
2021
Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing certain drug treatment. Due genetic differences at population level, hypersensitivity varied, thus common pharmacogenetics markers for one country might be different from another country, instance, HLA-A*31:01 is associated carbamazepine (CBZ)-induced SCARs in European Japanese while HLA-B*15:02 CBZ-induced Stevens-Johnson syndrome/toxic epidermal...
HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite dapsone, believed to be responsible for DHS. However, studies have not highlighted importance other polymorphisms dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated association HLA alleles cytochrome P450 (CYP) with SCAR Thai patients. A prospective...
Abstract Prior knowledge of allele frequencies cytochrome P450 polymorphisms in a population is crucial for the revision and optimization existing medication choices doses. In current study, frequency CYP2C9*2 , CYP2C9*3 CYP2C19*2 CYP2C19*3 CYP2C19*6 CYP2C19*17 CYP3A4 (rs4646437) alleles Thai across different regions Thailand was examined. Tests CYP2C9 were performed using TaqMan SNP genotyping assay CYP2C19 two methods; Luminex x Tag V3. The blood samples collected from 1205 unrelated...
HLA-B*13:01 -positive patients in Thailand can develop frequent co-trimoxazole hypersensitivity reactions. This study aimed to characterize drug-specific T cells from three hypersensitive presenting with either Stevens-Johnson syndrome or drug reaction eosinophilia and systemic symptoms. Two of the carried HLA allele interest, namely . Sulfamethoxazole nitroso sulfamethoxazole specific cell clones were generated lines patients. Clones characterized for antigen specificity cross-reactivity...
Abstract Background Allopurinol has been causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs). Nonetheless, there are no data describing whether other genetics a valid marker for prediction of allopurinol-induced cADRs patients addition to HLA-B*58:01 allele. The goal this study was identify suitable single nucleotide polymorphisms (SNPs) allopurinol induced among Thai patients. Methods: We conducted case-control...
plays a major role in the metabolism of various drugs. The most common genetic variants were
Objective: This study aimed to investigate the clinical impact of HLA-B*15:02 pharmacogenomics (PGx) testing before carbamazepine (CBZ)/oxcarbazepine (OXC) prescriptions and determine whether this PGx was associated with reduction CBZ/OXC-induced cutaneous adverse drug reactions (CADRs) in Thailand. Methods: retrospective observational cohort conducted by obtaining relevant PGx-testing data from electronic medical records during 2011–2020. 384 patient were included decision on CBZ/OXC usage...
DPYD polymorphisms have been widely found to be related 5-FU-induced toxicities. The aim of this study was establish significant associations between five single-nucleotide and 5-FU hematological toxicities in Thai colorectal cancer patients. were analyzed at the first second cycles administration 75 Genotyping performed using TaqMan real-time PCR. genotype frequencies DPYD*2A,1905 + 1 G > A 1774 C T all wild type. genetic testing for DPYD*5, 1627 G, 1896T C, DPYD*9A, 85 37.30% (AG; 34.60%,...
The response to 6-mercaptopurine (6-MP) can be altered by genetic polymorphisms in genes encoding drug-metabolizing enzymes and drug transporters. purpose of this study was investigate the association between (TPMT 719A > G (*3C), ITPA 94C A 123G A) transporters (MRP4 912C MRP4 2269G with 6-MP-related myelotoxicity hepatotoxicity Thai children acute lymphoblastic leukemia (ALL). prescribed dosage 6-MP its adverse effects were assessed from medical records during first 8 weeks 9–24...
The two common methylenetetrahydrofolate reductase (MTHFR) polymorphisms 677G>A and 1298A>C may have been affecting 5-FU toxicity in cancer patients for decades. Drug efficacy has also shown by previous studies to be affected. In this study, we investigated the effects of these on hematological treatment efficacy, provide enhanced pharmacological patients.This is a retrospective study involving 52 Thai colorectal who were treated with based therapy, using TaqMAN real-time PCR genotype MTHFR...
Background: The HLA-B is the most polymorphic gene, play a crucial role in drug-induced hypersensitivity reactions. There lot of evidence associating several risk alleles to life-threatening adverse drug reactions, and few them have been approved as valid biomarkers for predicting Objectives: objective this present study progression pharmacogenomics (PGx) testing Thai population during 10-year period, from 2011 2020. Methods: This was retrospective observational cohort conducted at Faculty...
Hyperbilirubinemia is the main mechanism that causes neonatal jaundice, and genetics one of risk factors hyperbilirubinemia. Therefore, this study aims to explore correlation between two genes, UGT1A1 SLCO1B1, hyperbilirubinemia in Thai neonates. One hundred thirty seven neonates were recruited from Division Clinical Chemistry, Ramathibodi Hospital. UGT1A1*28 *6 determined by pyrosequencing whereas, SLCO1B1 388A > G 521 T C genetic variants TaqMan® real-time polymerase chain reaction....
Abstract Allopurinol is causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs). The goal of this study was to identify genetic biomarkers single nucleotide polymorphisms (SNPs) for allopurinol induced cADRs among Thai patients. We conducted a case-control association after enrolling 57 patients with 101 tolerant controls. Genetic associated SNPs located on chromosome 6p21 were examined TaqMan® SNP genotyping assays...
Abstract: Background: Effects of UGT1A1*6 and UGT1A1*28 genetic polymorphisms on irinotecan-induced severe toxicities in Asian cancer patients are inconclusive. Also, ABCC2 c.3972C>T may affect toxicity irinotecan. It was aimed to assess the aggregated risk neutropenia or diarrhea taking irinotecan inherited UGT1A1*6, variants. Methods: Literature searched PubMed for eligible studies. Odds ratios (ORs) were measured using RevMan software where P-values<0.05 statistically significant....