A5048561277- Drug-Induced Adverse Reactions
- HIV/AIDS drug development and treatment
- Autoimmune Bullous Skin Diseases
- Pharmacogenetics and Drug Metabolism
- HIV Research and Treatment
- Urticaria and Related Conditions
- Autism Spectrum Disorder Research
- HIV/AIDS Research and Interventions
- Pharmacovigilance and Adverse Drug Reactions
- Genetics and Neurodevelopmental Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Attention Deficit Hyperactivity Disorder
- Asthma and respiratory diseases
- Pharmacological Effects and Toxicity Studies
- Lipoproteins and Cardiovascular Health
- Acute Lymphoblastic Leukemia research
- Contact Dermatitis and Allergies
- Inflammatory mediators and NSAID effects
- Eosinophilic Disorders and Syndromes
- Antiplatelet Therapy and Cardiovascular Diseases
- HIV-related health complications and treatments
- Biosimilars and Bioanalytical Methods
- Neutropenia and Cancer Infections
Ramathibodi Hospital
2016-2025
Mahidol University
2016-2025
University of Liverpool
2021-2025
Bumrungrad International Hospital
2021-2025
Burapha University
2023-2024
PharmacoGenetics (China)
2012-2022
Agencia de Evaluación de Tecnologías Sanitarias
2022
Instituto Nacional de Salud
2022
Sistema Nacional de Salud
2022
Chulalongkorn University
2021
The variant allele HLA‐B*15:02 is strongly associated with greater risk of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated carbamazepine or oxcarbazepine. HLA‐A*31:01 maculopapular exanthema, drug reaction eosinophilia systemic symptoms, SJS/TEN carbamazepine. We summarize evidence from the published literature supporting these associations provide recommendations for oxcarbazepine use based on HLA genotypes.
The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat infection. Efavirenz predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity treatment discontinuation. We summarize the evidence from literature provide therapeutic recommendations efavirenz prescribing based on genotypes.
Pharmacokinetics of mitragynine in man Satariya Trakulsrichai,1,2 Korbtham Sathirakul,3,4 Saranya Auparakkitanon,5 Jatupon Krongvorakul,5 Jetjamnong Sueajai,5 Nantida Noumjad,5 Chonlaphat Sukasem,5 Winai Wananukul2,6 1Department Emergency Medicine, Faculty Medicine Ramathibodi Hospital, 2Ramathibodi Poison Center, 3Department Pharmacy, Mahidol University, Bangkok, Thailand; 4Center for Drug Research Discovery and Development, Thammasat Univerisity, Prathumthani, 5Department Pathology,...
<h3>Objective:</h3> To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese Thai). <h3>Methods:</h3> We prospectively enrolled patients with OXC-cADRs Taiwan Thailand from 2006 to 2014, analyzed clinical course, latent period, drug dosage, organ involvement, complications, mortality. also investigated carrier rate <i>HLA-B*15:02</i>...
Phenytoin is one of the most common causative drugs several types severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug with eosinophilia systemic symptoms (DRESS). Genetic polymorphisms human leukocyte antigens (HLA) cytochromes P450 (CYP) have been proposed key elements for susceptibility to phenytoin-related SCAR in certain ethnicities. This study investigated associations between genetic HLA class I CYP2C9 a Thai...
A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether valid prediction of reactions other ethnicities or nonleprosy patients. The aim this study to investigate an association between HLA genotypes and severe cutaneous adverse (SCARs) Thai patients.HLA-B 15 with SCARs (11 reaction eosinophilia systemic symptoms, 4 Stevens-Johnson...
The HLA-B <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>∗</mml:mo></mml:math> 15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. HLA - B alleles associated maculopapular exanthema (MPE) and the drug reaction eosinophilia systemic symptoms (DRESS) among population never reported. aim of present study was carry out an analysis involvement cutaneous...
The aim of this study was to investigate the predisposition different types allopurinol-induced cutaneous adverse drug reactions (CADR), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN; SJS-TEN, n = 13), reaction with eosinophilia and systemic symptoms (DRESS, 10) Maculopapular eruption (MPE; 7), conferred by HLA-B (*) 58:01 in a Thai population.This case-control association compares 30 patients CADR, allopurinol-tolerant control (n 100), general population 1095)....
Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing certain drug treatment. Due genetic differences at population level, hypersensitivity varied, thus common pharmacogenetics markers for one country might be different from another country, instance, HLA-A*31:01 is associated carbamazepine (CBZ)-induced SCARs in European Japanese while HLA-B*15:02 CBZ-induced Stevens-Johnson syndrome/toxic epidermal...
Abstract HLA-B*15:02 screening before carbamazepine (CBZ) prescription in Asian populations is the recommended practice to prevent CBZ-induced Stevens-Johnson syndrome (CBZ-SJS). However, a number of patients have developed CBZ-SJS even having no . Herein, we present case Thai patient who had negative result but later CBZ-SJS. Further HLA typing revealed HLA-B*15:21 / B*13:01. member HLA-B75 serotype and commonly found Southeast populations. Based on this case, hypothesised that if all...
Background: Lamotrigine (LTG) is commonly used for treatment of epilepsy and bipolar disorder. It one the common cause cutaneous adverse drug reactions (CADR). Clinical symptoms LTG-induced CADR range from maculopapular exanthema (MPE) to severe (SCAR). This study aimed determine association with human leukocyte antigen (HLA) alleles in Thai patients. Methods: Fifteen patients [10 MPE; 4 Stevens-Johnson syndrome; 1 reaction eosinophilia systemic symptoms] 50 LTG-tolerant controls were...
Co‐trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case‐control study was conducted to investigate the involvement between genetic variants human leukocyte antigen ( HLA ) and CYP2C9 in CTX‐induced SCARs, including Stevens‐Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) drug reaction with eosinophilia systemic symptoms (DRESS) Thai patients. Thirty cases SCARs were enrolled compared 91 CTX‐tolerant controls 150 people from general...
HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite dapsone, believed to be responsible for DHS. However, studies have not highlighted importance other polymorphisms dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated association HLA alleles cytochrome P450 (CYP) with SCAR Thai patients. A prospective...