A5054057948- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Pharmacovigilance and Adverse Drug Reactions
- Chemotherapy-related skin toxicity
- Colorectal Cancer Treatments and Studies
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Fungal Infections and Studies
- Dermatology and Skin Diseases
- Mast cells and histamine
- Immune Cell Function and Interaction
- Colorectal and Anal Carcinomas
- Immunodeficiency and Autoimmune Disorders
- Nonmelanoma Skin Cancer Studies
- Cancer Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Trace Elements in Health
- Oral Health Pathology and Treatment
- Pharmaceutical studies and practices
- Eosinophilic Disorders and Syndromes
- Genital Health and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
Chang Gung University
2011-2025
Chang Gung Memorial Hospital
2016-2025
Xiamen Chang Gung Hospital
2022-2024
National Tsing Hua University
2023-2024
Linkou Chang Gung Memorial Hospital
2022
Keelung Chang Gung Memorial Hospital
2022
China Medical University
2019
China Medical University Hospital
2019
Royal Brompton Hospital
2019
Ramathibodi Hospital
2019
BACKGROUND. Cytotoxic T lymphocyte–mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, TNF-α granulysin, were observed in SJS-TEN patients recent studies, the optimal treatment for these diseases remains controversial. We aimed to evaluate efficacy, safety,...
<h3>Objective:</h3> To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese Thai). <h3>Methods:</h3> We prospectively enrolled patients with OXC-cADRs Taiwan Thailand from 2006 to 2014, analyzed clinical course, latent period, drug dosage, organ involvement, complications, mortality. also investigated carrier rate <i>HLA-B*15:02</i>...
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies medication related to SJS/TEN Asian populations. Thus, we analyzed registration databases from multiple countries who were treated during 1998–2017. A total 1,028 cases identified algorithm drug causality for necrolysis. Furthermore, those medications labeled...
Ethnicity has been shown to be a contributing risk factor regarding antiepileptic drug (AED)-induced severe cutaneous adverse reactions (SCARs). To increase the clinical and epidemiologic information in Asians, we investigated characteristics, outcome, tolerability toward alternative drugs for AED-induced SCARs.A total of 154 patients with SCARs, including Stevens-Johnson syndrome (SJS), toxic epidermal necrosis (TEN), rash eosinophilia systemic symptoms (DRESS), were analyzed demographic...
Abstract Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening skin disease characterized by relapsing and remitting flares of sterile neutrophilic pustules systemic inflammation. The definition GPP inconsistent globally, with large discrepancies in clinical management. To provide guidance on managing GPP, we conducted systematic literature search for articles published within the last decade PubMed Cochrane Library October 2022 held four consensus meetings 12...
Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications HFMD. However, exact mechanism is still unknown. Therefore, we conducted this study to elucidate nail changes Methods: We collected 11 patients suffering from samples all them were collected. Real time reverse transcription polymerase chain reaction (RT-PCR) sequencing for human enteroviruses (HEV) performed....
The bacterial microbiota in the skin and intestine of patients with psoriasis were different compared that healthy individuals. However, presence a distinct blood microbiome is yet to be investigated. In this study, we investigated differences communities plasma-derived extracellular vesicles (EVs) between moderate severe (PSOs) controls (HCs). plasma EVs from PSO (PASI > 10) (n = 20) HC 8) groups obtained via series centrifugations, patterns examined confirmed using transmission electron...
Purpose: Over the last decade, there has been tremendous progress in treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). To understand whether this resulted better ophthalmic outcomes, we aimed to study incidence severe ocular complications (SOCs) acute chronic stage among SJS/TEN patients, major causative medications, therapeutic effect medical surgical treatment. Methods: Using electronic records review patients Chang Gung Memorial Hospital Linkou Branch from...
Abstract Purpose Cutaneous toxicities are common adverse effects following epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) therapy. Zinc deficiency causes diverse diseases, including skin toxicities. Therefore, this study aimed to investigate the role of zinc in patients with EGFR‐TKI‐induced Experimental Design This retrospective enrolled 269 disorders who visited our hospital between January 2016 and December 2017. The toxicity severities plasma levels 101...
Abstract Background This study aimed to investigate the differences in microbiota composition of serum exosomes from patients with acute and chronic cholecystitis. Method Exosomes were isolated cholecystitis through centrifugation identified characterized using transmission electron microscopy nano-flow cytometry. Microbiota analysis was performed 16S rRNA sequencing. Results Compared cholecystitis, those exhibited lower richness diversity. Beta diversity revealed significant between The...
Abstract Tinea capitis (TC) mainly occurs in children, and related studies adults are rare. We aimed to investigate the current epidemiological, clinical mycological characteristics of TC compare adult paediatric patients northern Taiwan. conducted a retrospective study at Chang Gung Memorial Hospital, Linkou Branch, from 2014 2019. The dataset included age, sex, records underlying diseases, animal contact history, frequent hair salon visits, patterns, treatment outcome via chart or phone...