A5074346604- Gut microbiota and health
- Extracellular vesicles in disease
- Fungal Biology and Applications
- Drug-Induced Adverse Reactions
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Dietary Effects on Health
- MicroRNA in disease regulation
- Herbal Medicine Research Studies
- Reproductive System and Pregnancy
- Urticaria and Related Conditions
- Tryptophan and brain disorders
- Bacterial Infections and Vaccines
- Colorectal Cancer Treatments and Studies
- Asthma and respiratory diseases
- Exercise and Physiological Responses
- Health Systems, Economic Evaluations, Quality of Life
- IL-33, ST2, and ILC Pathways
- Tendon Structure and Treatment
- Biometric Identification and Security
- Antifungal resistance and susceptibility
- Bone health and osteoporosis research
- Bacterial Genetics and Biotechnology
- Economic and Financial Impacts of Cancer
Huaqiao University
2020-2025
Xiamen Chang Gung Hospital
2020-2025
University of Glasgow
2025
Far Eastern Memorial Hospital
2012-2025
Taipei Veterans General Hospital
2024-2025
National Yang Ming Chiao Tung University
2009-2025
National Formosa University
2025
Chang Gung Memorial Hospital
2020-2024
National Cheng Kung University
2024
China Medical University Hospital
2023
Abstract Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum a medicinal mushroom used in traditional Chinese medicine putative anti-diabetic effects. Here, we show that water extract of mycelium (WEGL) reduces body weight, insulin resistance mice fed high-fat diet (HFD). Our data indicate WEGL not only reverses HFD-induced gut dysbiosis—as indicated by the decreased Firmicutes-to-Bacteroidetes ratios endotoxin-bearing Proteobacteria...
Objective The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations the gut microbiota been described obesity type 2 diabetes. We examined possibility that H. mycelium (HSM) isolated fractions containing polysaccharides may prevent diet-induced diabetes by modulating composition microbiota. Design High-fat diet (HFD)-fed mice were treated with HSM or different...
Chronic obstructive pulmonary disease (COPD) is a global characterised by chronic obstruction of lung airflow interfering with normal breathing. Although the microbiota respiratory tract established to be associated COPD, causality gut in COPD development not yet established. We aimed address connection between composition and development, characterise bacteria their derived active components for amelioration.A murine cigarette smoking (CS)-based model strategies evaluating causal effects...
Abstract Although the mechanisms underlying cytotoxic effect of NK cells on tumor and intracellular bacteria have been studied extensively, it remains unclear how these kill extracellular bacterial pathogens. In this study, we examine human Mycobacterium kansasii M.tb. The mechanism is contact dependent requires two cytolytic proteins: perforin granulysin. Mycobacteria induce enhanced expression proteins via activation NKG2D/NCR cell-surface receptors signaling pathways involving ERK, JNK,...
Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective widely available would be beneficial. We examined whether medicinal mushroom Antrodia cinnamomea may reduce in mice fed a high-fat diet (HFD). Male C57BL/6J were HFD for 8 weeks to induce The treated water extract A. (WEAC), body weight, fat accumulation, inflammation markers,...
Cancer stem cells (CSCs) represent a unique sub-population of tumor with the ability to initiate growth and sustain self-renewal. Although CSC biomarkers have been described for various tumors, only few markers identified nasopharyngeal carcinoma (NPC). In this study, we show that CD24+ isolated from human NPC cell lines express genes (Sox2, Oct4, Nanog, Bmi-1, Rex-1), activation Wnt/β-catenin signaling pathway. possess typical characteristics include enhanced proliferation, increased colony...
(1) Background: Few antifungal drugs are currently available, and drug-resistant strains have rapidly emerged. Thus, the aim of this study is to evaluate effectiveness activity from a combinational treatment chitosan with clinical drug on Candida albicans tropicalis. (2) Methods: Minimum inhibitory concentration (MIC) tests, checkerboard assays, disc assays were employed determine effect or without other C. (3) Results: Treatment in combination fluconazole showed great synergistic fungicidal...
Abstract Objective The objective of this study was to assess the role point‐of‐care ultrasonography (POCUS) in diagnosis epiploic appendagitis, a relatively rare but important cause right lower quadrant (RLQ) abdominal pain, an emergency department setting. We aimed evaluate utility POCUS differentiating appendagitis from other acute conditions such as appendicitis and diverticulitis. Method This case‐based which 51‐year‐old female patient presented with 3‐day history RLQ pain. Initial...
Resveratrol, a natural phenolic compound found in red grapes and wine, exists as cis trans isomers. Recent studies have shown that trans-resveratrol possesses anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-tumor immunomodulatory properties. However, it remains unclear whether cis-resveratrol may exhibit similar activities. The objective of the present study was to examine effects cis- on production pro-inflammatory cytokines mediators human macrophages. We examined possibility...
Medicinal mushrooms have been used for centuries in Asian countries owing to their beneficial effects on health and longevity. Previous studies reported that a single medicinal mushroom may produce both stimulatory inhibitory immune cells, depending conditions, but the factors responsible this apparent dichotomy remain obscure. We show here water ethanol extracts of cultured mycelium from various species ( Agaricus blazei Murrill, Antrodia cinnamomea, Ganoderma lucidum Hirsutella sinensis)...
In developed countries, pulmonary nontuberculous mycobacteria (NTM) infections are more prevalent than Mycobacterium tuberculosis infections. Given the differences in pathogenesis of NTM and M. infections, separate studies needed to investigate pathological effects pathogens. Our previous study showed that anti-IFN-γ autoantibodies detected NTM-infected patients. However, role NK cells especially cell-derived IFN-γ this context has not been studied detail. current study, we show NK1.1 cell...
Abstract Iron availability affects swarming and biofilm formation in various bacterial species. However, how bacteria sense iron coordinate remains unclear. Using Serratia marcescens as a model organism, we identify here stage-specific iron-regulatory machinery comprising two-component system (TCS) the TCS-regulated chelator 2-isocyano-6,7-dihydroxycoumarin (ICDH-Coumarin) that directly senses modulates environmental ferric (Fe 3+ ) to determine initiation formation. We demonstrate RssA-RssB...
Ganoderma lucidum (G. lucidum) is a medicinal mushroom long used in Asia as folk remedy to promote health and longevity. Recent studies indicate that G. activates NK cells, but the molecular mechanism underlying this effect has not been studied so far. To address question, we prepared water extract of examined its on cells. We observed treatment increases cell cytotoxicity by stimulating secretion perforin granulysin. The activation involves an increased expression NKG2D natural receptors...
Novel pharmacological strategies capable of inhibiting pro-oncogenic MDM2 beyond its p53-dependent functions represents an increasingly attractive therapeutic strategy to treating solid and haematological cancers that are depdendent upon MDM2/MDMX, regardless TP53 mutational status. Utilising a novel first-in-class cell-penetrating peptide disruptor homo- heterodimerisation (DRx-098D), we demonstrate the anti-proliferative effect blocking dimerisation against panel human cancer cell lines...