A5086582449- Reproductive tract infections research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Leptospirosis research and findings
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Urinary Tract Infections Management
- Oral microbiology and periodontitis research
- T-cell and B-cell Immunology
- Fungal Biology and Applications
- Gut microbiota and health
- Hepatitis B Virus Studies
- Adolescent and Pediatric Healthcare
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- interferon and immune responses
- Erythrocyte Function and Pathophysiology
- Heme Oxygenase-1 and Carbon Monoxide
- Dietary Effects on Health
- Cytomegalovirus and herpesvirus research
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Circadian rhythm and melatonin
University of the Pacific
2016-2025
Chang Gung University
2015-2024
Chang Gung Memorial Hospital
2018-2024
Linkou Chang Gung Memorial Hospital
2017-2024
Université Paris Cité
2002-2020
American Dental Education Association
2020
Bridge University
2020
John Wiley & Sons (United States)
2020
Pacific University
2020
Délégation Paris 7
2009-2019
Abstract Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum a medicinal mushroom used in traditional Chinese medicine putative anti-diabetic effects. Here, we show that water extract of mycelium (WEGL) reduces body weight, insulin resistance mice fed high-fat diet (HFD). Our data indicate WEGL not only reverses HFD-induced gut dysbiosis—as indicated by the decreased Firmicutes-to-Bacteroidetes ratios endotoxin-bearing Proteobacteria...
Secretion of the proinflammatory cytokines, interleukin (IL)-1beta and IL-18, usually requires two signals. The first, due to microbial products such as lipopolysaccharide, initiates transcription cytokine genes accumulation precursor proteins. Cleavage secretion cytokines is mediated by caspase-1, in association with an inflammasome containing Nalp3, which can be activated binding extracellular ATP purinergic receptors. We show that treatment macrophages results production reactive oxygen...
Objective The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations the gut microbiota been described obesity type 2 diabetes. We examined possibility that H. mycelium (HSM) isolated fractions containing polysaccharides may prevent diet-induced diabetes by modulating composition microbiota. Design High-fat diet (HFD)-fed mice were treated with HSM or different...
A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms death, we characterized cytotoxic action two widely used quinolone antibiotics: ciprofloxacin (CPX) or norfloxacin (NFX). CPX NFX plus UV light (NFX*) induce membrane permeabilization (LMP), as detected by release cathepsins from lysosomes. Inhibition accumulation suppresses their capacity LMP and kill cells. CPX- NFX-triggered caspase-independent with hallmarks...
Invasive aspergillosis (IA) is a life-threatening disease that occurs in immunodepressed patients when infected with Aspergillus fumigatus. This fungus the second most-common causative agent of fungal after Candida albicans. Nevertheless, much remains to be learned about mechanisms by which A. fulmigatus activates innate immune system. We investigated inflammatory response conidia and hyphae fumigatus specifically, their capacity trigger activation an inflammasome. Our results show contrast...
Extracellular ATP is shown here to induce programmed cell death (or apoptosis) in thymocytes and certain tumor lines. EM studies indicate that the ATP-induced of susceptible cells follows morphological changes usually associated with glucocorticoid-induced apoptosis thymocytes. These include condensation chromatin, blebbing surface, breakdown nucleus. Cytotoxicity assays using double-labeled show ATP-mediated lysis accompanied by fragmentation target DNA. DNA can be set off but not...
Abstract The roles of Toll-like receptor (TLR) 2 and TLR4 in the host inflammatory response to infection caused by Chlamydia trachomatis have not been elucidated. We examined production TNF-α IL-6 wild-type TLR2 knockout (KO), KO murine peritoneal macrophages infected with mouse pneumonitis strain C. trachomatis. Furthermore, we compared outcomes genital tract control, KO, mice. Macrophages lacking produced significantly less IL6 active infection. In contrast, from mice consistently higher...
Interleukin-10 (IL-10) is a recently described pleiotropic cytokine secreted mainly by type 2 helper T cells. Previous studies have shown that IL-10 suppresses expression natural killer (NK) and 1 cells, thus down-regulating cell-mediated immunity stimulating humoral responses. We here report injected protein an efficient inhibitor of tumor metastasis in experimental (B16-F10) spontaneous (M27 Lox human melanoma) models vivo at doses do not toxic effects on normal or cancer Histological...