A5037574191- Genetics and Neurodevelopmental Disorders
- Immune Cell Function and Interaction
- Genomics and Rare Diseases
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Olfactory and Sensory Function Studies
- Neurological diseases and metabolism
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Cancer-related molecular mechanisms research
- Phytochemistry and Bioactive Compounds
- Protease and Inhibitor Mechanisms
- Medicinal Plants and Bioactive Compounds
- RNA regulation and disease
- Streptococcal Infections and Treatments
- Ion channel regulation and function
- Phytochemical compounds biological activities
- Ferroptosis and cancer prognosis
- Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-induced cardiotoxicity and mitigation
- RNA Research and Splicing
Ruijin Hospital
2008-2025
Shanghai Jiao Tong University
2009-2025
Hunan Normal University
2021-2025
Montefiore Medical Center
2025
Minhang District Central Hospital
2010-2024
Fudan University
2007-2024
XinHua Hospital
2021
Shanghai Research Institute of Sports Science
2016
Sichuan University
1993-2015
University of Oklahoma Health Sciences Center
2011
Extracellular ATP is shown here to induce programmed cell death (or apoptosis) in thymocytes and certain tumor lines. EM studies indicate that the ATP-induced of susceptible cells follows morphological changes usually associated with glucocorticoid-induced apoptosis thymocytes. These include condensation chromatin, blebbing surface, breakdown nucleus. Cytotoxicity assays using double-labeled show ATP-mediated lysis accompanied by fragmentation target DNA. DNA can be set off but not...
Antibacterial adhesives have favorable prospects to inhibit biofilms and secondary caries. The objectives of this study were investigate the antibacterial effect dental containing dimethylaminododecyl methacrylate (DMADDM) on different bacteria in controlled multispecies its regulating development biofilm for first time. material was synthesized, Streptococcus mutans, gordonii, sanguinis chosen form biofilms. Lactic acid assay pH measurement conducted production Anthrone method...
We examined the role of programmed cell death (apoptosis) in killer lymphocyte-mediated cytotoxicity. Two parameters death, 51Cr release and DNA fragmentation, were assayed. Lymphokine-activated cell- or CTL-mediated was inhibited target cells where transcription translation blocked. Dying showed ultrastructural changes typically associated with both apoptosis necrosis. In contrast, pretreated macromolecular synthesis inhibitors incubated lymphokine-activated morphologic signs necrosis only....
Apoptosis is the predominant form of cell death observed in a variety physiological and pathological conditions such as cancer involution, insect metamorphosis, development immune nervous systems, embryogenesis. The typical nuclear changes taking place apoptotic cells include extensive condensation chromatin internucleosomal DNA fragmentation into units 200 base pairs. However, mechanisms responsible for both have yet to be elucidated. In this study, micrococcal nuclease divalent cations,...
gamma/delta T cells have recently been described in association with a number of disorders, including autoimmune diseases. are thought to play cytotoxic role, but their mechanism action is not known. Several granule mediators cytotoxicity, pore-forming protein (perforin), and family serine esterases, isolated from lymphocytes (CTL), lymphokine-activated killer (LAK) cells, natural (NK) cells. We demonstrate here that also express these mediators. Northern blots show perforin, esterase 1 (SE...
Abstract Background Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline‐rich transmembrane protein 2 have been identified as the major pathogenic factor. Objectives We analyzed 600 paroxysmal patients nationwide who were by China Dyskinesia Collaborative Group to summarize phenotypes features provide new thoughts on diagnosis therapy. Methods The was composed departments neurology from 22...
In black cherry (Prunus serotina Ehrh.) macerates, the cyanogenic diglucoside (R)-amygdalin undergoes stepwise degradation to HCN catalyzed by amygdalin hydrolase (AH), prunasin hydrolase, and (R)-(+)-mandelonitrile lyase (MDL). A near full-length AH cDNA clone (pAH1), whose insert encodes isozyme I, has been isolated sequenced. I exhibits several features characteristic of beta-glucosidases BGA family, including their likely nucleophile center (isoleucine-threonine-glutamic...
Summary Streptococcus gordonii is an important member of the oral biofilm community. As commensal streptococcus, S. considered beneficial in promoting homeostasis. CcpA known as central regulator carbon catabolite repression Gram‐positive bacteria and also involved control virulence gene expression. To further establish role , effect on formation natural competence was investigated. These phenotypic traits have been suggested to be streptococci coping with environmental stress. Here we...
Paeonol, a natural product derived from the root of Cynanchum paniculatum (Bunge) K. Schum and Paeonia suffruticosa Andr. (Ranunculaceae) has attracted extensive attention for its anti-cancer proliferation effect in recent years. The present study examined role paeonol suppressing migration invasion pancreatic cancer cells by inhibiting TGF-β1/Smad signaling.Cell viability was evaluated MTT colonial formation assay. Migration capabilities were cell scratch-wound healing assay Boyden chamber...
ABSTRACT Background Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesias. Only one‐third PKD patients are attributed to proline‐rich transmembrane protein 2 ( PRRT2 ) mutations. Objective We aimed explore potential causative gene for PKD. Methods A cohort 196 ‐negative probands were enrolled whole‐exome sequencing (WES). Gene Ranking, Identification and Prediction Tool, a method case–control analysis, was applied identify candidate genes. Another 325...
With the aging of population, health issues among older people have drawn increasing societal attention. The rapid development intelligent technology provides innovative solutions to addressing these challenges. This study aims explore impact smart wearable devices on people's outcomes while discussing mechanism physical exercise, provide a new perspective and exercise strategy for maximizing positive role in adult management. Utilizing data from China Longitudinal Aging Social Survey...
Abstract Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and driven primarily by macrophage‐mediated lipid accumulation inflammatory processes. Conventional cardiovascular pharmacotherapies address these mechanisms but often show limited efficacy, highlighting need for innovative agents capable of effectively reducing inflammation minimal toxicity. In this study, decursin, monomer derived from traditional Chinese...
<h3>Objective:</h3> Currently, there is an urgent need to identify immunotherapeutic biomarkers increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC). Homologous recombination deficiency (HRD) can modify tumor microenvironment by increasing presence tumor-infiltrating lymphocytes and therefore might serve as a biomarker response. We aimed analyze mutational pattern HR-associated genes in Chinese GC its relevance profile clinical <h3>Methods:</h3> A...
CTL, NK cells, and lymphokine-activated killer (LAK) cells are cytolytic lymphocytes known to produce a pore-forming protein, named perforin or cytolysin, that lyses target by forming large pores on the plasma membrane of cell. Other proteins besides found in cytoplasmic granules effector lymphocytes, these include family serine esterases. Ultrastructural immunogold labeling studies with antibodies against esterase (MTSP-1, also as granzyme A SE-1) show all LAK CTL cell line contain...