A5072585020- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Insect symbiosis and bacterial influences
- Neurogenetic and Muscular Disorders Research
- Mosquito-borne diseases and control
- Hereditary Neurological Disorders
- Malaria Research and Control
- Energy and Environment Impacts
- Reproductive Biology and Fertility
- CRISPR and Genetic Engineering
- Neurological diseases and metabolism
- Insect and Pesticide Research
- Insect Resistance and Genetics
- Invertebrate Immune Response Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Cerebral Palsy and Movement Disorders
- Air Quality Monitoring and Forecasting
- Entomopathogenic Microorganisms in Pest Control
- Sperm and Testicular Function
- Prenatal Screening and Diagnostics
- Horticultural and Viticultural Research
- Renal and related cancers
- Genomics and Rare Diseases
- Ovarian function and disorders
- Nuclear Structure and Function
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2022-2024
Suzhou Municipal Hospital
2023
Ministry of Education of the People's Republic of China
2022
Ruijin Hospital
2019
Shanghai Jiao Tong University
2019
ABSTRACT Background Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesias. Only one‐third PKD patients are attributed to proline‐rich transmembrane protein 2 ( PRRT2 ) mutations. Objective We aimed explore potential causative gene for PKD. Methods A cohort 196 ‐negative probands were enrolled whole‐exome sequencing (WES). Gene Ranking, Identification and Prediction Tool, a method case–control analysis, was applied identify candidate genes. Another 325...
Aedes aegypti is a vector that transmits various viral diseases, including dengue and Zika. The radiation-based sterile insect technique (SIT) has limited effect on mosquito control because of the difficulty in irradiating males without reducing their mating competitiveness. In this study, sex pheromone heptacosane was applied to Ae. investigate whether it could enhance competitiveness irradiated males.Heptacosane smeared abdomens were allowed mate with untreated virgin females. insemination...
Malaria is a mosquito-borne infectious disease, caused by unicellular Apicomplexan protozoa of the genus Plasmodium. The sexual stage Plasmodium one most fascinating aspects life cycle, yet relatively less explored until now. production sexually fit gametocytes through gametocytogenesis essential to transmission parasite into an anopheline mosquito vector. Understanding how regulated promotes identification novel drug targets and also development transmission-blocking vaccines that would...
To explore whether embryo culture with melatonin (MT) can improve the embryonic development and clinical outcome of patients repeated cycles after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) failure, immature oocytes from controlled ovarian superovulation were collected for maturation (IVM) ICSI. The obtained embryos cultured 0, 10-11, 10-9, 10-7 10-5 M MT medium respectively, 10-9 was screened out as optimal concentration. Subsequently, 140 who underwent failed...
Abstract Malaria, a mosquito-borne infectious disease, is caused by the unicellular apicomplexan protozoa of genus Plasmodium. For malaria parasite transmission, essential sexual stage includes production gametocytes through gametocytogenesis in vertebrate hosts and formation gametes from gametogenesis mosquito vectors. Whereas each female gametocyte forms single immotile macrogamete, male produces eight flagella-like microgametes process called exflagellation. We identified conserved...
Abstract Spastic paraplegia type 4 (SPG4), caused by SPAST mutations, is the most predominant subtype of hereditary spastic paraplegia. Most documented SPG4 patients present as pure form, with complex form rarely reported. We described clinical and genetic features 20 phenotypes further explored genotype–phenotype correlations. collected detailed data all assessed their phenotypes. gene mutations were identified Multiplex ligation‐dependent probe amplification in combination whole exome...
ABSTRACT Genetic editing is a powerful tool for functional characterization of genes in various organisms. With its simplicity and specificity, the CRISPR-Cas9 technology has become popular tool, which introduces site-specific DNA double-strand breaks (DSBs), then leverages endogenous repair pathway DSB via homology-directed (HDR) or more error-prone non-homologous end joining (NHEJ) pathways. However, Plasmodium parasites, lack typical NHEJ selects through HDR when homologous template...
Cooking oil fume (COF) is an important source of indoor air pollution which severely affects human health, and sufficient vitamin D3 (VitD3) necessary for maternal child health. However, the effects cooking fume-derived PM2.5 (COF-PM2.5) on birth outcomes whether VitD3 could protect from adverse caused by COFs-PM2.5 are still unclear.Twenty-four pregnant rats were divided into 4 groups treated with various treatments: normal feeding, intratracheal instillation, intragastric administration,...
Background Blastocyst biopsy has become the most mainstream method. Currently, there are two blastocyst strategies. Many studies have compared advantages and disadvantages between blastomere biopsy, but fewer articles For moment, no published explored entire set of information on embryo development, next-generation sequencing results, clinical outcomes, including baby’s health status with Methods A total 323 preimplantation genetic testing cycles from April 2018 to May 2020, 178 Strategy 145...
Abstract Objective Spastic paraplegia type 2 (SPG2) is an X‐linked recessive (XLR) form of hereditary spastic (HSP) caused by mutations in proteolipid protein 1 ( PLP1 ) gene. We described the clinical and genetic features three unrelated families with reviewed ‐related cases worldwide to summarize genotype–phenotype correlations. Methods The probands were 23, 26, 27 years old, respectively, progressively aggravated walking difficulty as well lower limb spasticity. Detailed physical...
The objective of this study was to examine the relationship between weekly specific maternal air pollution exposures and low birth weight. We fitted a distributed lag nonlinear model (DLNM) analyze exposure-response association delayed effects pollutants on risk for assumed that all live births have 40 gestational weeks.The 1st week 40th week, week.The included 71,809 (from July 1, 2016, June 30, 2019), which 2,391 (3.33%) exhibited results demonstrated exposure pregnant women PM10 at 22-30...
ABSTRACT The entomopathogenic fungus Beauveria bassiana provides an eco-friendly substitute to chemical insecticides for mosquito control. Nevertheless, its widespread application has been hindered by comparatively slow efficacy in eliminating mosquitoes. To augment the potency of B. against Aedes mosquitoes, a novel recombinant strain, Bb -Cyt1Aa, was developed incorporating Bacillus thuringiensis toxin gene Cyt1Aa into . virulence -Cyt1Aa evaluated aegypti and albopictus using insect...
Abstract Background Pf AP2-EXP2 is located within chromosome 6 of Plasmodium falciparum recently identified to be undergoing an extensive selective sweep in West African isolates. The gene encoding this transcription factor, AP2-EXP2, essential and thus likely subject purifying selection that limits variants the parasite population despite its genomic location. Methods 72 field samples 801 clinical sequences from Pf6 MalariaGEN dataset Ghanaian origin, were integrated analysed. Results A...