A5015894942- Hereditary Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics and Neurodevelopmental Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Blood disorders and treatments
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Advanced Neuroimaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Pulmonary Hypertension Research and Treatments
- Gastric Cancer Management and Outcomes
- Glioma Diagnosis and Treatment
- Genomics and Rare Diseases
- Nuclear Receptors and Signaling
- Heat shock proteins research
- Radiomics and Machine Learning in Medical Imaging
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
Zhejiang University
2011-2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Liaoning Cancer Hospital & Institute
2012-2025
China Medical University
2020-2025
Guangdong Medical College
2025
Affiliated Hospital of Taishan Medical University
2024
Shandong First Medical University
2024
First Affiliated Hospital Zhejiang University
2024
Fourth Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports tick bites suggested that infection could contribute to FTLS. Many tick-transmitted microbial pathogens were tested for by PCR/RT-PCR and/or indirect immunofluorescence assay (IFA). However, only 8% (24/285) samples collected from 2007 2010 positive human granulocytic anaplasmosis (HGA), suggesting other be involved. Here, we used an unbiased metagenomic...
Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate...
The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions. Glymphatic dysfunction plays pathogenic role in Parkinson's disease (PD); however, molecular mechanism PD remains elusive. To explore whether matrix metalloproteinase-9 (MMP-9)-mediated β-dystroglycan (β-DG) cleavage is involved regulation aquaporin-4 (AQP4) polarity-mediated PD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced A53T...
Pulmonary vascular injury by toxins can induce neointimal formation, pulmonary arterial hypertension (PAH), right ventricular failure, and death. We showed previously that simvastatin attenuates smooth muscle proliferation in pneumonectomized rats injected with the alkaloid toxin monocrotaline. The present study was undertaken to investigate efficacy of its mechanism reversing established occlusion hypertension.Pneumonectomized monocrotaline at 4 weeks demonstrated severe PAH 11 (mean artery...
Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder in world. Several and rare genetic risk variants associated with PD pathogenesis have been identified, predominantly persons of European descent, but contributions to familial are largely unknown for Han Chinese. Here, we present a trio-based study explore association between de novo-altered genes early onset We found that 12 novo mutations were biologically connected each other likely be disease-risk...
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their activation mechanisms remain unclear. Here we report cryo-electron microscopy (cryo-EM) structures of KCNQ2-CaM in complex with three activators, namely drug cannabidiol (CBD), lipid phosphatidylinositol 4,5-bisphosphate (PIP2), HN37 (pynegabine), an clinical trial, either closed or open...
Abstract Background Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. encodes a large putative serine/threonine kinase GTPase activity. Increased activity plays critical role pathogenic mutant-induced neurodegeneration vitro . Little known about physiological function LRRK2. Results We have recently identified Drosophila line P-element insertion an...
Platelets and neutrophils contribute to the development of acute lung injury (ALI). However, mechanism by which platelets make this contribution is incompletely understood. We investigated whether two most abundant platelet chemokines, CXCL7, induces neutrophil chemotaxis activation, CXCL4, does neither, mediate ALI through complementary pathogenic pathways. To examine role platelet-derived chemokines in pathogenesis using Cxcl7-/- Cxcl4-/- knockout mice that express human CXCL7 or we...
Introduction: China has the most people with Parkinson disease (PD) in world and is estimated to have over half of worldwide PD population. The objective this study was analyze corresponding burden for past decades. Method: Data on related were retrieved from Global Burden Disease (GBD) 2019 study. annual percentage changes (EAPCs) calculated assess temporal trends, ratio years lived disability (YLDs) disability-adjusted life (DALYs) used as an index evaluate healthcare system. Result:...
China has the largest population of people with dementia in world and is estimated to have approximately a quarter entire worldwide, bringing heavy burden on public healthcare systems. We aimed analyze Alzheimer's disease other dementias over past three decades.The data owing from 1990 2019 were extracted Global Burden Disease (GBD) datasets. The annual percentage changes (EAPCs) calculated assess temporal trends, ratio years lived disability (YLDs) disability-adjusted life-years (DALYs) was...
Triptolide (PG490, 97% pure) is a diterpenoid triepoxide with potent anti-inflammatory and immunosuppressive effects in transformed human bronchial epithelial cells T (Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC-H, Kao PN. J Biol Chem 274: 13443–13450, 1999). Triptolide, an IC 50 of ∼20–50 ng/ml, inhibits normal cell expression interleukin (IL)-6 IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-α, or IL-1β. Nuclear runoff luciferase reporter gene...
Abstract Background Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline‐rich transmembrane protein 2 have been identified as the major pathogenic factor. Objectives We analyzed 600 paroxysmal patients nationwide who were by China Dyskinesia Collaborative Group to summarize phenotypes features provide new thoughts on diagnosis therapy. Methods The was composed departments neurology from 22...
Charcot-Marie-Tooth (CMT) disease, the most common hereditary peripheral neuropathy, is highly clinically and genetically heterogeneous, mutations in at least 18 genes have been identified. Recently, small heat shock protein 27 (Hsp27) were reported to cause CMT disease type 2F distal motor neuropathy.To investigate frequency phenotypic features of an Hsp27 mutation Chinese patients with disease.DNA samples from 114 unrelated screened for by polymerase chain reaction direct sequencing. A...
ABSTRACT Background Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesias. Only one‐third PKD patients are attributed to proline‐rich transmembrane protein 2 ( PRRT2 ) mutations. Objective We aimed explore potential causative gene for PKD. Methods A cohort 196 ‐negative probands were enrolled whole‐exome sequencing (WES). Gene Ranking, Identification and Prediction Tool, a method case–control analysis, was applied identify candidate genes. Another 325...
: Currently, Parkinson's disease (PD) diagnosis is mainly based on medical history and physical examination, there no objective consistent basis. By the time of diagnosis, would have progressed to middle late stages. Pilot studies shown that a unique smell was present in skin sebum PD patients. This increases possibility noninvasive using an odor profile.
To observe the characteristics of ocular biological parameters in children with transfusion-dependent β-thalassemia (TDT) and effect iron chelator treatment on them.
ABSTRACT Objective Our aim was to research the neuromelanin‐sensitive magnetic resonance imaging (NM‐MRI) features of locus coeruleus (LC) in essential tremor (ET) patients various cognitive states and explore relationships between these cognition. Methods We recruited three groups participants, including 30 ET with mild impairment (ET‐MCI), 57 normal cognition (ET‐NC), 105 healthy controls (HCs). All participants underwent MRI scanning clinical evaluation. Through NM‐MRI images, we compared...