A5015011842- Genetics, Aging, and Longevity in Model Organisms
- Bacterial Identification and Susceptibility Testing
- Extracellular vesicles in disease
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Genetic Associations and Epidemiology
- Urologic and reproductive health conditions
- Sperm and Testicular Function
- Mitochondrial Function and Pathology
- Genetic Mapping and Diversity in Plants and Animals
- Antifungal resistance and susceptibility
- Yersinia bacterium, plague, ectoparasites research
- Asthma and respiratory diseases
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Fungal Infections and Studies
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Escherichia coli research studies
- Diet and metabolism studies
- Salmonella and Campylobacter epidemiology
- Autism Spectrum Disorder Research
- Viral gastroenteritis research and epidemiology
Xuzhou Medical College
2016-2025
Xuzhou Central Hospital
2024
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangdong Provincial People's Hospital
2023
Edith Cowan University
2023
The University of Western Australia
2023
The University of Queensland
2023
UNSW Sydney
2023
Yixing People's Hospital
2019
Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder in world. Several and rare genetic risk variants associated with PD pathogenesis have been identified, predominantly persons of European descent, but contributions to familial are largely unknown for Han Chinese. Here, we present a trio-based study explore association between de novo-altered genes early onset We found that 12 novo mutations were biologically connected each other likely be disease-risk...
Raman spectroscopy (RS) is a widely used analytical technique based on the detection of molecular vibrations in defined system, which generates spectra that contain unique and highly resolved fingerprints system. However, low intensity normal scattering effect greatly hinders its application. Recently, newly emerged surface enhanced (SERS) overcomes problem by mixing metal nanoparticles such as gold silver with samples, enhances signal effects orders magnitudes when compared regular RS. In...
Over the past decades, conventional methods and molecular assays have been developed for detection of tuberculosis (TB). However, these techniques suffer limitations in identification Mycobacterium (Mtb), such as long turnaround time low sensitivity, etc., not even mentioning difficulty discriminating antibiotics-resistant Mtb strains that cause great challenges TB treatment prevention. Thus, with easy implementation rapid diagnosis infection are high demand routine diagnosis. Due to...
Many bacterial components in indoor dust can evoke inflammatory pulmonary diseases. Bacteria secrete nanometre-sized vesicles into the extracellular milieu, but it remains to be determined whether bacteria-derived are pathophysiologically related diseases.To evaluate (EV) air pathogenesis of inflammation and/or asthma.Indoor was collected from a bed mattress an apartment. EV were prepared by sequential ultrafiltration and ultracentrifugation. Innate adaptive immune responses evaluated after...
Abstract Background Recurrent bladder cancer is the most common type of urinary tract malignancy; nevertheless, mechanistic basis for its recurrence uncertain. Innovative technologies such as single‐cell transcriptomics and spatial (ST) offer new avenues studying recurrent tumour progression at level while preserving data. Method This study integrated RNA (scRNA) sequencing ST profiling to examine microenvironment (TME) six tissues (three from primary tumours three tumours). Findings scRNA...
Many studies shown that neurological diseases are associated with neural mitochondrial dysfunctions and microbiome composition alterations. Since mitochondria emerged from bacterial ancestors during endosymbiosis, mitochondria, bacteria had analogous genomic characteristics, similar bioactive compounds comparable energy metabolism pathways. Therefore, it is necessary to rationalize the interactions of intestinal microbiota mitochondria. Recent have identified dysfunction as a critical...
Allergen-specific T-cell responses orchestrate airway inflammation, which is a characteristic of asthma. Recent evidence suggests that noneosinophilic asthma can be developed by mixed Th1 and Th17 cell when exposed to lipopolysaccharide (LPS)-containing allergens.To evaluate the therapeutic or adverse effects acetyl salicylic acid (ASA) on expression Th1-type Th17-type inflammation induced exposure LPS-containing allergens.Th1 + Th2 mouse models were generated intranasal sensitization with...
Parkinson disease (PD) is the second most common neurodegenerative disorder in aged population and thought to involve many genetic loci. While a number of individual single nucleotide polymorphisms (SNPs) have been linked with PD, remain be found no known markers or combinations them useful predictive value for sporadic PD cases. The collective effects genome wide minor alleles SNPs, allele content (MAC) an individual, recently shown quantitative variations numerous complex traits model...
Glycogen is a highly branched polysaccharide that widely present in all life domains. It has been identified many bacterial species and functions as an important energy storage compound. In addition, it plays roles transmission, pathogenicity, environmental viability. There are five essential enzymes (coding genes) directly involved glycogen metabolism, which forms single operon glgBXCAP with suboperonic promoter glgC gene Escherichia coli. Currently, there no comparative study of how the...
Candidiasis causes high morbidity and mortality among immunocompromised patients. Antifungal drug resistance cytotoxicity highlight the need of effective antifungal therapeutics. In this study, we found that kalopanaxsaponin A (KPA), a triterpenoid saponin natural product, could inhibit proliferation various Candida species, exerted fungicidal effect against C . albicans To further explore its action mode, spectrofluorophotometer, fluorescence microscopy transmission electron were performed,...
Abstract Background There is a lack of biomarkers for distinguishing non-obstructive azoospermia (NOA) patients with successful sperm retrieval (Sp+) from those failed (Sp-). This study aimed to determine the potential extracellular vesicles tRNA-derived small RNA (tsRNA) as novel non-invasive biomarker by microdissection testicular extraction (mTESE). Methods The included 18 NOA and 23 (Sp-), 15 obstructive (OA) patients, 5 idiopathic oligospermia (IO) 12 healthy people. Seminal plasma...
It has long been assumed that most parts of a genome and genetic variations or SNPs are non-functional with regard to reproductive fitness. However, the collective effects have yet be examined by experimental science. We here developed novel approach examine relationship between traits total amount in panels reference populations. identified minor alleles (MAs) each panel MA content (MAC) inbred strain carried for set genotypes determined these panels. MAC was nearly linearly linked...
Abstract The neutral theory has been used as a null model for interpreting nature and produced the Recent Out of Africa anatomically modern humans. studies, however, have established that genetic diversities are mostly at maximum saturation levels maintained by selection, therefore challenging explanatory power rendering present molecular human origins untenable. Using improved methods public data, we revisited evolution found sharing variations among racial groups to be largely result...
Fungal infections caused by Candida albicans have posed a persistent threat to human health. Existing clinical antifungal drugs are constrained issues such as drug resistance and side effects. Compounds containing maleimide rings been verified possess properties, although the specific molecular mechanisms which they exert this activity yet be fully understood. A total of 40 compounds were synthesised in present study, 12 derivatives that possessed properties subsequently identified. The...
Bacterial infections pose significant threats to human health, and prudent antibiotic use remains a key strategy for disease treatment control. However, global escalation of drug resistance among pathogenic bacteria presents formidable challenge. Probiotics have emerged as promising approach combating bacterial infections. In this study, we investigated the antibacterial activity BTS1-knockout (BTS1-KO) Saccharomyces cerevisiae. Our findings demonstrate its effective inhibition pathogen...
Stem cell treatment may enhance erectile dysfunction (ED) in individuals with cavernous nerve injury (CNI). Nevertheless, no investigations have directly ascertained the implications of varying amounts human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) on ED. We compare efficacy three various doses HUC-MSCs as a therapeutic strategy for Sprague-Dawley rats (total = 175) were randomly allocated into five groups. A total 35 underwent sham surgery and 140 endured bilateral CNI...
ABSTRACT As an emerging technology, Raman spectroscopy (RS) has been used to identify pathogenic bacteria with excellent performance. The aim of this study was verify the diagnosis accuracy RS in identification bacteria. This meta‐analysis systematically evaluated for We searched electronic databases PubMed and Web Science obtain relevant articles; STATA 15.1 analyze all sensitivities, specificies, their 95% confidence interval (CI). summary receiver operating characteristic curves (SROC)...
Gut microbiota have been shown to influence the social behaviors of their hosts, while variations in host genetics can affect composition microbiome. Nonetheless, degree which genetic microbial populations impact behavior, as well any potential transgenerational effects, remains inadequately understood. Utilizing C. elegans a model organism, we identified 77 strains E. coli from total 3,983 mutants that significantly enhanced aggregation behavior through various neurobehavioral pathways....
Abstract Mutations in mitochondrial genome have epistatic effects on organisms depending the nuclear background, but a role for compatibility of mitochondrial-nuclear genomes (mit-n) quantitative nature complex trait remains unexplored. We studied panel recombinant inbred advanced intercrossed lines (RIAILs) C. elegans that were established from cross between N2 and HW strains. determined content type (HW or N2) each RIAIL strain. found degree mit-n was correlated with lifespans not foraging...
Schizophrenia is a common neuropsychiatric disorder with lifetime risk of 1%. Accumulation polygenic variations has been found to be an important factor. Recent studies showed role for the enrichment minor alleles (MAs) SNPs in complex diseases such as Parkinson's disease. Here we similarly studied genome wide MAs schizophrenia using public datasets. Relative matched controls, cases higher average values allele content (MAC) or amount per subject. By prediction analysis based on weighted...
Candidiasis has long been a threat to human health, but cytotoxicity and resistance always block the usefulness of antifungal agents. The ability switch between yeast hypha is one most discussed virulence trait attributes pathogenic fungus Candida albicans. morphological transition provides novel target for developing drugs. aim present study was explore activity mechanism teasaponin (TS), generally regarded as safe natural product, in inhibiting filamentation C. albicans, hoping provide an...
Candidiasis caused by Candida albicans infection has long been a serious human health problem. The pathogenicity of C. is mainly due to its virulence factors, which are novel targets antifungal drugs for low risk resistance development. In this study, we identified maleimide compound [1-(4-methoxyphenyl)-1hydro-pyrrole-2,5-dione, MPD] that exerts effective anti-virulence activity. It could inhibit the process adhesion, filamentation, and biofilm formation in albicans. addition, it exhibited...