A5046942454- Gut microbiota and health
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Gout, Hyperuricemia, Uric Acid
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Myasthenia Gravis and Thymoma
- Liver Disease Diagnosis and Treatment
- Plant Gene Expression Analysis
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Clostridium difficile and Clostridium perfringens research
- Job Satisfaction and Organizational Behavior
- Grit, Self-Efficacy, and Motivation
- Amoebic Infections and Treatments
- Viral Infections and Immunology Research
- Intramuscular injections and effects
- Reproductive tract infections research
- Emotional Labor in Professions
- Galectins and Cancer Biology
- Botulinum Toxin and Related Neurological Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
City University of Hong Kong
2018-2024
City University of Hong Kong, Shenzhen Research Institute
2020-2024
Hainan University
2024
RMIT University
2024
Hunan University
2023
BGI Group (China)
2016-2022
BGI Genomics
2016-2022
Affiliated Hospital of North Sichuan Medical College
2021-2022
Yibin University
2020
University of Calgary
2019
Abstract The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for in patients with different abnormalities investigate their relationships clinical indicators, 1,914 Chinese adults were enrolled 16S rRNA gene sequencing this retrospective study. Based on composition, Random forest classifiers constructed screen the (Group OA) or without diseases O) from healthy individuals H), high accuracies observed discrimination of Group O OA (areas under...
Abstract Emerging evidence indicates an association between gut microbiome and arthritis diseases including gout. However, how which bacteria affect host urate degradation inflammation in gout remains unclear. Here we performed a metagenome analysis on 307 fecal samples from 102 patients 86 healthy controls. Gout metagenomes significantly differed those of The relative abundances Prevotella , Fusobacterium Bacteroides were increased gout, whereas Enterobacteriaceae butyrate-producing species...
Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder in world. Several and rare genetic risk variants associated with PD pathogenesis have been identified, predominantly persons of European descent, but contributions to familial are largely unknown for Han Chinese. Here, we present a trio-based study explore association between de novo-altered genes early onset We found that 12 novo mutations were biologically connected each other likely be disease-risk...
Abstract This research investigated how and under what conditions thriving at work affects career attitudes behaviors. Using an experimental design ( n = 174), Study 1 found that the effects of on satisfaction, commitment, engagement were mediated by resilience. The positive effect resilience resilience‐mediated stronger when achievement orientation was higher. 2 verified these findings with a survey another sample 296 employees. These studies offer important insights for human resource...
Abstract Background MicroRNAs (miRNAs) have been shown to play a critical role in the development and progression of nasopharyngeal carcinoma (NPC). Although accumulating studies performed on molecular mechanisms NPC, miRNA regulatory networks cancer remain largely unknown. Laser capture microdissection (LCM) deep sequencing are powerful tools that can help us detect integrated view miRNA-target network. Methods Illumina Hiseq2000 was used screen differentially expressed miRNAs...
Colorectal cancer (CRC) causes high morbidity and mortality worldwide, noninvasive gut microbiome (GM) biomarkers are promising for early CRC diagnosis. However, the GM varies significantly based on ethnicity, diet living environment, suggesting varied biomarker performance in different regions. We performed a metagenomic association analysis stools from 52 patients 55 corresponding healthy family members who lived together to identify Chongqing, China. The of differed that controls. A total...
Abstract Background Myasthenia gravis (MG) is an acquired immune-mediated disorder of the neuromuscular junction that causes fluctuating skeletal muscle weakness and fatigue. Pediatric MG adult have many different characteristics, current diagnostic methods for children are not quite fit. Previous studies indicate alterations in gut microbiota may be associated with MG. However, it has been determined whether altered pediatric patients. Methods Our study recruited 53 patients 46 age-...
The acquisition of a substantial volume precisely dense pixel-annotated samples plays crucial role in the effective training deep learning-based change detection models. Nevertheless, real-world scenarios, pairwise labeling massive bitemporal remote sensing images is often laborious and time-consuming, resulting lack labeled samples. In this article, we propose novel point-based weakly supervised learning approach, called as consistency-aligned regional growth network (CARGNet), for...
Drawing upon the theory of underdog or challenge-based entrepreneurship, this study tested a moderated mediation model to answer how and when childhood financial difficulty affects adults' entrepreneurial intention. It proposes that work–family conflict would serve as mechanism between This also moderating effect openness experience on relation The data were collected from 217 full-time adult employees in China. Results supported individuals' was positively related current conflict, which...
Purpose Workplace thriving is a psychological state that promotes employee health and development. In addition to presenting useful instrument captures the nature of work life in China, purpose this paper investigate important factors influence one’s status within national context. Design/methodology/approach Using diverse approaches across different samples, Study 1 contextualized content workplace scale (WTS) fit Chinese 2 tested effects learning goal orientation, exploration at role...
Horizontal gene transfer (HGT) phenomena pervade the gut microbiome and significantly impact human health. Yet, no current method can accurately identify complete HGT events, including transferred sequence associated deletion insertion breakpoints from shotgun metagenomic data. Here, we develop LocalHGT, which facilitates reliable swift detection of events data, delivering an accuracy 99.4%-verified by Nanopore data-across 200 samples, achieving average F1 score 0.99 on 100 simulated...
Abstract Metagenomic studies have revealed the critical roles of complex microbial interactions, including horizontal gene transfer (HGT) and functional redundancy (FR), in shaping gut microbiome’s capacity resilience. However, lack comprehensive data integration systematic analysis approaches has limited in-depth exploration HGT FR dynamics across large-scale microbiome datasets. To address this gap, we present GutMetaNet (https://gutmetanet.deepomics.org/), a first-of-its-kind database...
Abstract Motivation The microbial community plays an essential role in human diseases and physiological activities. functions of microbes can differ due to strain-level differences the genome sequences. Shotgun metagenomic sequencing allows us profile strains communities practically. However, current methods are underdeveloped highly similar sequences among strains. We observe that genotypes at same single nucleotide variant (SNV) locus be speculated by genotype frequencies. Also, variants...
Premature ovarian insufficiency (POI) is a group of heterogeneous disorders characterized by decreased reserve and increased follicle stimulating hormone (FSH) levels. It rarely associated with short stature. FIGLA mutations POI are identified regard to heterozygosity; till date, only one affected family has been homozygous in but without functional evaluation. Here, we described two patients from consanguineous China. An 18-year-old girl her sister presented primary amenorrhea FSH...
Horizontal Gene Transfer (HGT) refers to the transfer of genetic materials between organisms through mechanisms other than parent-offspring inheritance. HGTs may affect human health a large number microorganisms, especially gut microbiomes which body harbors. The transferred segments lead complicated local genome structural variations. Details structure can elucidate effects HGTs.In this work, we propose graph-based method reconstruct strains from metagenomics data at HGT sites. is...
To explore the correlation between platelet endothelial aggregation receptor-1 (PEAR1) genetic polymorphism and pulmonary thromboembolism (PTE). Variant loci of PEAR1 gene were screened in a PTE pedigree, followed by verification using Sanger sequencing. These polymorphic validated 101 patients 132 matched normal MassARRAY single nucleotide (SNP) genotyping methods. The frequency differences allele genotypes compared Hardy–Weinberg equilibrium test Chi-square test. SNP was analyzed comparing...
CTX-M-140, a novel CTX-M-type extended-spectrum β-lactamase (ESBL), was identified in cephalosporin-resistant clinical isolates of Proteus mirabilis CTX-M-140 contained an alanine-to-threonine substitution at position 109 compared to its putative progenitor, CTX-M-14. When it expressed Escherichia coli isogenic background, conferred 4- 32-fold lower MICs cephalosporins than those with CTX-M-14, indicating that the phenotype attributable this single substitution. For four mutants CTX-M-14...
Abstract Background The human gut microbiome is associated with numerous diseases. whole-genome shotgun metagenomics sequencing helps accumulate a massive amount of data. However, few curated integrated platforms are available to explore the vast dataset. Advances in data generation pose new challenges researchers attempting analyze, visualize, and reuse published Result GutMeta (human GUT METAgenomics analysis platform) one-stop online metagenomic research platform that integrates database,...
Microbial abundance profiles are applied widely to understand diseases from the aspect of microbial communities. By investigating associations species or genes, we can construct molecular ecological networks (MENs). The MENs often constructed by calculating Pearson correlation coefficient (PCC) between genes. In this work, also multimodal mutual information (MMI) MENs. members which drive concerned referred as key drivers. We proposed a novel method detect First, partitioned MEN into...
Various distance functions for evaluating the differences between gene expression profiles have been proposed in past. Such a function would output low value if are strongly correlated—either negatively or positively—and vice versa. One popular is absolute correlation distance, d =1−|ρ|, where ρ some similarity measures, such as Pearson Spearman correlation. However, fails to fulfill triangular inequality, which guaranteed better performance at vector quantization, allowed fast data...
ABSTRACT Emerging evidence has indicated an association between the gut microbiome and arthritis diseases including gout. This metagenomic study aims to investigate possible role of microbiota in development The results exhibit gout patients have higher abundance Prevotella, Fusobacterium spp. Bacteroides spp., whereas healthy controls Enterobacteriaceae butyrate-producing species, Roseburia Butyrivibrio Coprococcus anti-inflammatory Faecalibacterium prausnitzii . Functional analysis shows...