A5101755546- Gut microbiota and health
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Cancer Cells and Metastasis
- Immune cells in cancer
- Proteoglycans and glycosaminoglycans research
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Clostridium difficile and Clostridium perfringens research
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Gastrointestinal motility and disorders
- Animal Disease Management and Epidemiology
- Mycobacterium research and diagnosis
- Hedgehog Signaling Pathway Studies
- Autoimmune and Inflammatory Disorders Research
- Pancreatic and Hepatic Oncology Research
China Three Gorges University
2024
China Energy Engineering Corporation (China)
2024
Peking University
2024
Nanjing Agricultural University
2008-2024
Peking University First Hospital
2024
Jiangsu Academy of Agricultural Sciences
2018-2024
Hackensack University Medical Center
2024
Army Medical University
2014-2023
Xinqiao Hospital
2014-2023
Chongqing Medical University
2020-2023
Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays an important pathogenic role.However, the current drugs for IBD treatment are far from optimal.Previous researches indicated that parthenolide (PTL) had not only anti-cancer properties but also strong anti-inflammatory activities.Rationale: To investigate protective effect of PTL on colon inflammation and demonstrate underlying microbiota-dependent mechanism.Methods: Colon severity mouse model...
Abstract Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions a sensor mediating crosstalk commensal microbiome host immunity, but influence of TLR4 on shaping responses during colon inflammation remains poorly characterized. We investigated whether different susceptibilities colitis wild-type (WT) −/− mice were...
BACKGROUND: The nuclear factor-kB (NF-kB) family of transcriptional regulators are central mediators the cellular inflammatory response. Although constitutive NF-kB signaling is present in most human tumours, mutations pathway members rare, complicating efforts to understand and block aberrant activity cancer. METHODS: To identify additional genetic alterations that drive ependymoma, we sequenced whole genomes (WGS) 41 tumours matched normal blood, transcriptomes (RNAseq) 77 tumours....
Abstract Receptor-interacting protein kinase 3 (RIPK3) is essential for mucosal repair in inflammatory bowel diseases (IBD) and colorectal cancer. However, its role tumor immunity unknown. Here, we report that decreased RIPK3 cancer correlates with the accumulation of myeloid-derived suppressor cells (MDSC). Deficiency boosted tumorigenesis via immunosuppressive activity MDSCs. Reduction MDSC elicited NFκB-transcribed COX-2, which catalyzed synthesis prostaglandin E2 (PGE2). PGE2 exacerbated...
// Yong Qin 1 , Bo Tang Chang-Jiang Hu Yu-Feng Xiao Rui Xie Xin Yu-Yun Wu Hui Dong Shi-Ming Yang Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China Correspondence to: Yang, e-mail: shimingyang@yahoo.com Keywords: hTERT, ZEB1, EMT, CRC Received: April 12, 2015 Accepted: October 08, Published: 20, ABSTRACT In human cancer, high telomerase expression is correlated with tumor aggressiveness and metastatic potential. Telomerase...
microRNAs have been implicated in hepatocellular carcinoma (HCC) metastasis, which is predominant cause of high mortality these patients. Although an increasing body evidence indicates that miR-149 plays important role the growth and metastasis multiple types cancers, its progression HCC remains unknown. Here, we demonstrated was significantly down-regulated HCC, correlated with distant TNM stage statistical significance. A survival analysis showed decreased expression a poor prognosis as...
Colorectal cancer (CRC) causes high morbidity and mortality worldwide, noninvasive gut microbiome (GM) biomarkers are promising for early CRC diagnosis. However, the GM varies significantly based on ethnicity, diet living environment, suggesting varied biomarker performance in different regions. We performed a metagenomic association analysis stools from 52 patients 55 corresponding healthy family members who lived together to identify Chongqing, China. The of differed that controls. A total...
Objective Mindfulness-based interventions have been widely demonstrated to be effective in reducing stress, alleviating mood disorders, and improving quality of life; however, the underlying mechanisms remained fully understood. Along with advanced research microbiota-gut-brain axis, this study aimed explore impact gut microbiota on effectiveness responsiveness mindfulness-based cognitive therapy (MBCT) among high trait anxiety populations. Design A standard MBCT was performed 21 young...
Human telomerase reverse transcriptase (hTERT) is a central regulator of multiple hallmarks tumors. However, the potential roles hTERT in tumor invasion and metastasis underlying molecular mechanisms remain poorly understood. Here, we found that expression gastric cancer (GC) was significantly associated with an advanced TNM stage, lymphatic metastasis. Survival analysis identified as independent prognostic factor for survival GC patients. promoted cells by binding to c-Myc recruiting...
Abstract: Gastric cancer is one of the leading causes tumor-related deaths in world. Current treatment options do not satisfy doctors and patients, new therapies are therefore needed. Cerium oxide nanoparticles (CNPs) have been studied as a potential therapeutic approach for treating many diseases. However, their effects on human gastric currently unknown. Therefore, this study, we aimed to characterize CNPs cell lines (MKN28 BGC823). cells were cocultured with different concentrations CNPs,...
Chronic gastritis caused by Helicobacter pylori ( H. ) infection has been widely recognized as the most important risk factor for gastric cancer. Analysis of interaction between key participants in mucosal immunity and is expected to provide insights treatment chronic prevention Heparanase an endoglycosidase that degrades heparan sulfate, resulting remodeling extracellular matrix thereby facilitating extravasation migration immune cells towards sites inflammation. also releases sulfate-bound...
Pseudorabies virus (PRV) is a highly contagious viral disease, which leads to severe financial losses in the breeding industry worldwide.