A5100389128- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Advanced Mathematical Physics Problems
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Neurobiology and Insect Physiology Research
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Stability and Controllability of Differential Equations
- Insect and Arachnid Ecology and Behavior
- S100 Proteins and Annexins
Chongqing Cancer Hospital
2020-2025
Chongqing University
2008-2025
Xinqiao Hospital
2015-2025
Army Medical University
2015-2025
Huazhong University of Science and Technology
2014-2025
Tongji Hospital
2014-2025
Fifth Hospital of Shijiazhuang
2020-2025
Fudan University
2013-2025
Huaiyin Institute of Technology
2025
Gansu Academy of Agricultural Sciences
2025
Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear...
Mushroom bodies are prominent neuropils found in annelids and all arthropod groups except crustaceans. First explicitly identified 1850, the mushroom differ size complexity between taxa, as well different castes of a single species social insect. These differences led some early biologists to suggest that endow an with intelligence or ability execute voluntary actions, opposed innate behaviors. Recent physiological studies mutant analyses have divergent interpretations. One interpretation is...
A costimulatory signal through B7 to its counter-receptor CD28 on T cells enhances cell activation. We have generated recombinant retroviruses containing cDNA for murine and transduced a panel of tumor lines with varying immunogenicity study the effect costimulation antitumor immunity. In contrast progressive outgrowth all wild-type (B7-) tumors in unimmunized syngeneic mice, four immunogenic tumors, lymphoma RMA, EL4, mastocytoma P815, melanoma E6B2, regressed completely when gene....
Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, mechanism lipid accumulation and corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation colon cancer confirmation other models, here we determine that deficiency monoacylglycerol lipase (MGLL) results overload TAMs. Functionally, MGLL inhibits CB2 cannabinoid receptor-dependent tumor progression inoculated genetic models. Mechanistically, promotes...
Metabolic reprogramming is critical for the polarization and function of tumor-associated macrophages (TAM) hepatocarcinogenesis, but how this occurs unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, downregulated hepatocellular carcinoma (HCC)-associated macrophages, which correlated with tumorigenesis enhanced accumulation M2 TAMs. Mechanistically, RIPK3 deficiency TAMs reduced reactive oxygen species significantly inhibited...
Objective Treg/Th17 imbalance plays an important role in rheumatoid arthritis (RA). Maresin 1 (MaR1) prompts inflammation resolution and regulates immune responses. We explored the effect of MaR1 on RA progression investigated correlation between balance. Methods Both patients with healthy controls were recruited into study. Collagen-induced (CIA) model was constructed to detect clinical score, histopathological changes ratio. Purified naive CD4+ T-cells used study its differentiation...
•Epithelial subtype 1, 2 and 3 were mainly found in the adenocarcinoma 4 was present adenosquamous carcinoma.•Tumors with ErbB pathway mutations harbored a larger population of 1 epithelial cells, Tregs, M2 macrophages.•Increased MDK these tumors interacted its receptor LRP1 to promote immunosuppressive macrophage differentiation.•Crosstalk between macrophage-secreted CXCL10 CXCR3 on Tregs induced GBC mutations. Background & AimsOur previous genomic whole-exome sequencing (WES) data...
Abstract The presence of amyloid‐β (Aβ) plaques in the brain is a hallmark pathological feature Alzheimer's disease (AD). Transgenic mice overexpressing mutant amyloid precursor protein (APP), or both APP and presenilin‐1 (APP/PS1), develop Aβ similar to those AD patients, have been proposed as animal models which test experimental therapeutic approaches for clearance Aβ. However, at present there no vivo whole‐brain imaging method detect men. A novel presented brains transgenic by magnetic...