A5101983959- Renal Transplantation Outcomes and Treatments
- Head and Neck Cancer Studies
- Galectins and Cancer Biology
- Organ and Tissue Transplantation Research
- Immune cells in cancer
- Speech Recognition and Synthesis
- Adenosine and Purinergic Signaling
- Aluminum Alloys Composites Properties
- Kruppel-like factors research
- Pregnancy and Medication Impact
- Erythropoietin and Anemia Treatment
- T-cell and B-cell Immunology
- Advanced Computing and Algorithms
- RNA Interference and Gene Delivery
- Voice and Speech Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood groups and transfusion
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- S100 Proteins and Annexins
- Neurological Complications and Syndromes
- Neonatal Respiratory Health Research
- Chronic Kidney Disease and Diabetes
- Fuel Cells and Related Materials
- Brain Tumor Detection and Classification
Tongji Hospital
2009-2024
Huazhong University of Science and Technology
2009-2024
Ministry of Education of the People's Republic of China
2014
Galectin-9 serves opposing roles in the innate and adaptive immune systems. triggers T-cell immunoglobulin mucin-3 (Tim-3) on T helper type 1 (Th1) cells, thereby terminating Th1 immunity protecting allografts from host attacks. Meanwhile, galectin-9 promotes maturation of dendritic cells (DCs) that deliver proinflammatory signals. We previously showed significantly prolongs cardiac allograft survival mice but failed to induce tolerance. This study aimed at improving administration protocol...
Aims The nephrotoxicity of cyclosporine A (CsA) accounts for dysfunction kidney allografts in the clinic. Short-term intensified dosing using enteric-coated mycophenolate sodium (EC-MPS) may facilitate CsA sparing after transplantation without compromising safety. Methods In a 12-month, single-centre open-label prospective trial, 180 de novo live-donor transplant recipients at low-immunological risk were randomised to low-dose group which received low dose cyclosporine, short-term EC-MPS...
Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy metabolism and has been shown to be protective in ischaemia/reperfusion injury (IRI). We hypothesized that preactivation AMPK with an activator before donor heart procurement could protect grafts from cold IRI.Donor Sprague-Dawley rats were injected intravenously 5-amino-imidazole-4-carboxamide ribonucleotide (AICAR) or vehicle 30 min procurement. Heart then preserved histidine-tryptophan-ketoglutarate...
The early diagnosis of laryngeal cancer (LCA) is crucial for prognosis, driving our search an accurate, precise, and sensitive deep learning model to assist in LCA detection.
Objective: To evaluate the indication, safety and effectiveness of transoral robotic surgery (TORS) for oropharyngeal cancer based on our preliminary experience. Methods: Twelve patients, including six with tonsil cancer, five tongue base one posterior pharyngeal wall who underwent TORS Da Vinci Si surgical system from March 2017 to October 2018 at Tongji Hospital Huazhong University Science Technology were respectively analyzed. And time, intraoperative blood loss, postoperative local...
Objective To investigate the effects of T. gondii soluble tachyzoite antigen (STAgs) on survival time mouse heart allograft and possible mechanism. Methods The STAgs were prepared by pulverizing with ultrasound ice. Cervical heterotopic transplantations done using Balb/c mice as donors, C57BL/6 recipients.The recipients classified randomly into three groups: syngeneic group, acute rejection group STAgs-treated group. in injected subcutaneously 0. 1 ml PBS (5 μg) at 4th day before...
Objective To explore the expression level of Tim-3,the marker activated T_H 1 cells.in T lymphocytes in different sites from recipients with acute rejection.Methods The model cervical heterotopic heart transplantation was established mice Two groups were get up:the isograft group(C57BL/6→C57BL/6) and allograft group (Balb/c→C57BL/6).Lymphocytes isolated peripheral blood,spleens,draining lymph nodes grafts 3 or 6 days after transplantation.The TIM-3 CD4~+ CD8~+ subsets detected by flow...
Objective To prepare recombinant adenovirus pAd-gal-9 containing murine galectin-9 and explore galectin-9's pro-apoptotic effect on T lymphocytes. Methods The plas-mid pAd/CMV/V5-DEST-gal-9 was prepared by conventional molecular cloning LR reaction. pAd/ CMV/V5-DEST-gal-9 linearlized Pac I transfected into 293A cells with Lipofectin 2000. Eight days after transfection, the were subjected to freeze/thraw circle for three times supernatant collected centrifugation. Higer titer produced...