A5101656675- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Corneal surgery and disorders
- Metabolomics and Mass Spectrometry Studies
- Dermatology and Skin Diseases
- Metabolism and Genetic Disorders
- Salivary Gland Disorders and Functions
- Allergic Rhinitis and Sensitization
- Inflammasome and immune disorders
- Diabetes Management and Research
- Medicinal Plants and Bioactive Compounds
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Mitochondrial Function and Pathology
- Caveolin-1 and cellular processes
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Heme Oxygenase-1 and Carbon Monoxide
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Diet, Metabolism, and Disease
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
People's Hospital of Cangzhou
2000-2025
Intel (United States)
2025
Pennsylvania Hospital
2024
Baylor College of Medicine
2012-2024
Ocular Surface Center
2012-2024
First Affiliated Hospital of Bengbu Medical College
2024
Bengbu Medical College
2024
Gansu Provincial Hospital
2024
To evaluate production and activity of metalloproteinase (MMP)-9 on the ocular surface patients with dysfunctional tear syndrome (DTS) determine any correlation between MMP-9 clinical parameters.Forty-six newly diagnosed DTS 18 control subjects were recruited. Complete examinations performed. Tear was assessed an assay in 1 microL unstimulated fluid. Using conjunctival epithelial cells from 19 16 controls, levels its regulating cytokine mRNA transcripts evaluated by semiquantitative...
Abstract There is mounting evidence that the microbiome has potent immunoregulatory functions. We assessed effects of intestinal dysbiosis in a model Sjögren syndrome (SS) by subjecting mice to desiccating stress (DS) and antibiotics (ABX). characterized conjunctival, tongue fecal profiles patients with SS. Severity ocular surface systemic disease was graded. 16S ribosomal RNA gene sequencing microbiota. ABX + DS had significantly worse dry eye phenotype compared controls, decrease...
Recent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects on diabetic mice explore underlying mechanisms.The type 2 diabetes were investigated. Increasing doses (25, 50 100 mg·kg(-1) ·day(-1)) administered p.o. db/db for 8 weeks. Biochemical analysis histopathological examinations...
Network anomaly detection using dimensionality reduction techniques has received much recent attention in the literature. For example, previous work aggregated netflow records into origin-destination (OD) flows, yielding a smaller set of dimensions which can then be mined to uncover anomalies. However, this approach only identify OD flow is anomalous, not particular IP flow(s) responsible for anomaly. In paper we show how one use random aggregations flows (i.e., sketches) enable more precise...
Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2 diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate therapeutic effect on high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD) by investigating underlying mechanisms. Mice were fed with HFD or regular diet, randomly divided into two groups, and treated vehicle for 8 weeks. Then, biochemical analyses histopathological examinations conducted vivo vitro....
Conjunctival goblet cell (GC) loss in dry eye is associated with ocular surface inflammation. This study investigated if conjunctival GCs contribute to immune tolerance. Antigens applied the surface, imaged by confocal microscopy, passed into stroma through passages (GAPs) wild type C57BL/6 (WT), while ovalbumin (OVA) was retained epithelium of SAM pointed domain containing ETS transcription factor (Spdef) knockout mice (Spdef-/-) that lack and are a novel model eye. Stimulated GC...
Hydrophone is a key component of marine seismic exploration systems, divided into scalar hydrophone and vector hydrophone. The electrochemical has attracted much attention due to its high sensitivity low-frequency detection capability. With the development noise reduction technology, high-frequency been effectively suppressed, while still difficult control, which become issue in monitoring underwater target radiation noise. traditional based on molecular electron transfer (MET) principle...
Epithelial cells are involved in the regulation of innate and adaptive immunity response to different stresses. The purpose this study was investigate if alkali-injured corneal epithelia activate through nucleotide-binding oligomerization domain-containing protein (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway. A unilateral alkali burn (AB) created central cornea C57BL/6 mice. Mice received either no topical treatment or with sodium butyrate (NaB),...
Commensal bacteria play an important role in the formation of immune system but their maintenance homeostasis at ocular surface and lacrimal gland remains poorly understood. This study investigated eye phenotype germ-free conventional C57BL/6J mice. Our results showed that mice had significantly greater corneal barrier disruption, goblet cell loss, total inflammatory CD4+ T infiltration within compared to conventionally housed group. A frequency CD4+IFN-γ+ cells was observed glands. Females...
The retention of plasma low-density lipoprotein (LDL) particles in subendothelial space following transcytosis across the endothelium is initial step atherosclerosis. Whether or not C-reactive protein (CRP) can directly affect LDL clear. Here we have examined effect CRP on endothelial cells and explored underlying mechanisms.Effects FITC-labelled were with human umbilical vein venous rings vitro and, vivo, ApoE(-/-) mice. Laser scanning confocal microscopy, immunohistochemistry Oil Red O...
The NLRP3 inflammasome, a multiprotein cytosolic complex that activates the IL-1 family of cytokines, plays an important role in atherosclerosis (AS). High-sensitivity c-reactive protein (hs-CRP) is widely recognized as major cardiovascular risk predictor and recent studies name CRP levels. Mounting evidence has indicated subendothelial retention apolipoprotein B100-containing lipoproteins, such low-density lipoprotein (LDL), initial step atherogenesis, usually termed "response to...
Ectoine, a novel natural osmoprotectant, protects bacteria living in extreme environments. This study aimed to explore the therapeutic effect of ectoine for dry eye disease. An experimental model was created C57BL/6 mice exposed desiccating stress (DS) with untreated as controls (UT). DS were dosed topically 0.5–2.0% or vehicle control. Corneal epithelial defects detected via corneal smoothness and Oregon Green dextran (OGD) fluorescent staining. Pro-inflammatory cytokines chemokines...
Salidroside (SAL) is an active component of Rhodiola rosea with documented antioxidative properties. The purpose this study to explore the mechanism protective effect SAL on hydrogen peroxide- (H 2 O -) induced endothelial dysfunction. Pretreatment human umbilical vein cells (HUVECs) significantly reduced cytotoxicity brought by H . Functional studies rat aortas found that rescued endothelium-dependent relaxation and superoxide anion (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Oxidized low density of lipoprotein (oxLDL) is the major lipid found in atherosclerotic lesion and elevated plasma oxLDL recognized to be a risk factor atherosclerosis. Whether could transported across endothelial cells initiate changes remains unknown. In an established vitro cellular transcytosis model, present study that traffic vascular further regulation endogenous ceramide production by metabolizing enzyme inhibitors significantly altered cells. It was acid sphingomyelinase inhibitor,...
Aging is a significant risk factor for dry eye. Here we used murine aging model to investigate the effects of on antigen presenting cells (APCs) and generation pathogenic T helper (Th)-1 cells. Our results showed that APCs from aged mice accumulate at conjunctiva, have higher levels co-activation marker CD86 lower aldehyde dehydrogenase activity. Using topical ovalbumin peptide as surrogate antigen, observed an increased number antigen-loaded in draining cervical lymph nodes group loss tight...