A5100701317- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Connexins and lens biology
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- Ubiquitin and proteasome pathways
- Corneal Surgery and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Ocular Oncology and Treatments
- Advanced Neural Network Applications
- Heat shock proteins research
- Ophthalmology and Visual Health Research
- Anorectal Disease Treatments and Outcomes
Sun Yat-sen University
2016-2025
Beijing University of Chemical Technology
2024-2025
Soochow University
2007-2025
First Affiliated Hospital of Soochow University
2007-2025
Kunming University of Science and Technology
2025
Shandong University
2013-2024
Guangdong Provincial Center for Disease Control and Prevention
2022-2024
Key Laboratory of Guangdong Province
2011-2024
Guizhou University
2022-2024
Shandong First Medical University
2022-2024
purpose. To assess the prevalence of refractive error and visual impairment in school-age children a metropolitan area southern China. methods. Random selection geographically defined clusters was used to identify 5 15 years age Guangzhou. Children 22 were enumerated through door-to-door survey examined 71 schools 19 community facilities from October 2002 January 2003. The examination included acuity measurements, ocular motility evaluation, retinoscopy, autorefraction under cycloplegia...
Abstract Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE subsequent photoreceptors have been observed age-related macular degeneration (AMD). Although the consequences GSH depletion described previously, questions remain regarding molecular mechanisms. We herein examined downstream effects on stress-induced premature (SIPS) cell human cells. Briefly, cultured ARPE-19 cells...
Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E−/− [ApoE−/−] and LDL receptor−/− [Ldlr−/−] mice), persistent cold exposure stimulated plaque growth by increasing lipid...
CC-Cruiser is an artificial intelligence (AI) platform developed for diagnosing childhood cataracts and providing risk stratification treatment recommendations. The high accuracy of was previously validated using specific datasets. objective this study to compare the diagnostic efficacy decision-making capacity between ophthalmologists in real-world clinical settings.This multicentre randomized controlled trial performed five ophthalmic clinics different areas across China. Pediatric...
Atrophic ("dry") form of age-related macular degeneration (AMD) is a leading cause vision loss characterized by retinal pigment epithelium (RPE) and the ensuing photoreceptor degeneration. cGAS-STING signaling key cytosolic DNA sensor system in innate immunity have recently been shown promotes RPE However, expression regulation therapeutic potential cGAS STING are not explored retina under dry AMD pathogenic conditions. Our analysis shows upregulated RNA increased chromatin accessibility...
PURPOSE: To compare the intraoperative and short-term postoperative outcomes of cataract surgery performed with torsional mode conventional ultrasound using Infiniti Vision System (Alcon Laboratories). SETTING: Cataract Service, Zhongshan Ophthalmic Center, Sun-Yat-Sen University, Guangzhou, China. METHODS: In this randomized comparative study, 525 eyes were assigned to phacoemulsification by or (US) mode. The was an experienced surgeon, evaluated examiner who masked treatment assignments....
Abstract Background Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is major cause of irreversible blindness worldwide that lacks approved effective therapies, validated treatment targets clear molecular mechanisms. We sought to explore the potential mechanisms underlying causal link between high IOP glaucomatous RGCs death. Methods A murine ischemia/ reperfusion (RIR) model an vitro oxygen glucose...
Purpose To assess the demographics and distribution of corneal astigmatism before cataract surgery in Chinese patients. Setting State Key Laboratory Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Design Clinic-based cross-sectional study. Methods From July 2009 to May 2011, preoperative bilateral partial coherence interferometry (IOLMaster) was performed consecutive patients having surgery. Patient keratometric data were recorded. Results The mean age...
Purpose To establish and validate a universal artificial intelligence (AI) platform for collaborative management of cataracts involving multilevel clinical scenarios explored an AI-based medical referral pattern to improve efficiency resource coverage. Methods The training validation datasets were derived from the Chinese Medical Alliance Artificial Intelligence, covering healthcare facilities capture modes. labelled using three-step strategy: (1) mode recognition; (2) cataract diagnosis as...
BackgroundMedical artificial intelligence (AI) has entered the clinical implementation phase, although real-world performance of deep-learning systems (DLSs) for screening fundus disease remains unsatisfactory. Our study aimed to train a clinically applicable DLS diseases using data derived from real world, and externally test model photographs collected prospectively settings in which would most likely be adopted.MethodsIn this national evidence study, we trained DLS, Comprehensive AI...
Fibrosis is a chronic process involving development and progression of multiple diseases in various organs responsible for almost half all known deaths. Epithelial-mesenchymal transition (EMT) the vital organ fibrosis. Lens an elegant biological tool to investigate fibrosis because its unique properties. Using gain- loss-of-function assays, different lens models, here we demonstrated that microRNA (miR)-26a miR-26b, members miR-26 family have key roles EMT They can significantly inhibit...
Recent reform of medical education highlights the growing concerns about capability current educational model to equip school students with essential skills for future career development. In field ophthalmology, although many attempts have been made address problem decreasing teaching time and increasing load course content, a body literature indicates need ophthalmology strategies. Flipped classroom is new pedagogical in which develop basic understanding materials before class, use in-class...
Abstract FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating + tumors are unavailable. Here we show that modulates tumor vessels by recruiting NG2 pricytes onto microvessels through a PDGFRβ-dependent mechanism. intrinsically resistant to clinically available targeting VEGF PDGF. Surprisingly, dual the PDGF signaling produces superior antitumor effect breast cancer fibrosarcoma models. Mechanistically, inhibition...
Significance Retinopathy is the leading cause of blindness, and development effective therapy urgently needed. Here, we defined an unprecedented subgroup microglia that responsible for causing retinopathy under hypoxia. Mechanistic studies demonstrated signaling pathway hypoxia-induced necroptosis retinal microglia, i.e., hypoxia–RIP1–RIP3–MLKL axis, triggered explosive release FGF2, which in its turn to induce neovascularization. Simultaneous targeting necroptosis–FGF2 VEGF produces...
Mobile health (mHealth) services have been widely used in medical and management through mobile devices multiple channels, such as smartphones, wearable equipment, healthcare applications (Apps), platforms. However, the number of users who are currently receiving mHealth is small. In China, more than 70% internet never services. Such imbalanced situation could be attributed to users' traditional concept treatment, psychological factors (such low self-efficacy) privacy concerns. The purpose...
Although VEGF-B was discovered as a VEGF-A homolog long time ago, the angiogenic effect of remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit together other VEGF family members are being used to treat patients various neovascular diseases. It is therefore critical have better understanding underlying mechanisms. Using comprehensive in vitro vivo methods models, we reveal here for first an unexpected surprising function...