A5051628883- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- FOXO transcription factor regulation
- PI3K/AKT/mTOR signaling in cancer
- Cholesterol and Lipid Metabolism
- Ovarian cancer diagnosis and treatment
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Sun Yat-sen University
2017-2025
Karolinska Institutet
2020-2023
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of intertwined interactions between tumour stromal components in metastasis provide a new paradigm for PDAC therapy.
Patients with cervical cancer (CCa) lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positively correlate LNM. However, precise role and FABP5 remain unknown. Methods: The diagnostic value as a predictor evaluated tumour samples. functional its upstream downstream regulatory...
Abstract Cancer spread to lymph nodes predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long noncoding RNA LNMICC associates with node metastasis primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated promoted by reprogramming fatty acid metabolism, recruiting nuclear NPM1 promoter binding protein FABP5. We also found prometastatic...
Abstract FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating + tumors are unavailable. Here we show that modulates tumor vessels by recruiting NG2 pricytes onto microvessels through a PDGFRβ-dependent mechanism. intrinsically resistant to clinically available targeting VEGF PDGF. Surprisingly, dual the PDGF signaling produces superior antitumor effect breast cancer fibrosarcoma models. Mechanistically, inhibition...
Abstract Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC LNM. However, molecular mechanism in is unclear. In present study, we demonstrated that fatty acid synthase (FASN), one key enzymes lipid metabolism, had upregulated expression samples and was correlated Moreover, multivariate Cox proportional hazards analysis identified FASN as an...
Abstract Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role circRNAs cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that circRNA derived from TADA2A gene (hsa_circ_0043280) was significantly downregulated CCa and this reduction expression correlated with poor prognosis. Furthermore, our results hsa_circ_0043280 functions tumor suppressor inhibit growth metastasis CCa. Mechanistically, competitively sponges...
Abstract Epithelial-mesenchymal transition (EMT) is an essential step to drive the metastatic cascade lymph nodes (LNs) in cervical cancer cells. However, few of them metastasize successfully partially due increased susceptibility immunosurveillance conferred by EMT. The precise mechanisms cells orchestrate EMT and immune evasion remain largely unexplored. In this study, we identified a lncRNA termed node metastasis associated suppressor (LNMAS), which was downregulated LN-positive patients...
Abstract The circadian clock in animals and humans plays crucial roles multiple physiological processes. Disruption of homeostasis causes detrimental effects. Here, it is demonstrated that the disruption rhythm by genetic deletion mouse brain muscle ARNT‐like 1 (Bmal1) gene, coding for key transcription factor, augments an exacerbated fibrotic phenotype various tumors. Accretion cancer‐associated fibroblasts (CAFs), especially alpha smooth actin positive myoCAFs, accelerates tumor growth...
Significance The clinical efficacy of immunotherapy in cancer patients is limited. We have developed a zebrafish model that allows us to visualize the metastatic cell-killing effect by tumor-infiltrating lymphocytes and chimeric antigen receptor T cells vivo at single-cell level. This accurately predicts cell-mediated therapy. Our data provide an platform for validating antimetastatic effects human immunotherapy. Based on our findings, it highly recommended anticancer isolated from or...
The prognosis for cervical cancer (CC) patients with lymph node metastasis (LNM) is extremely poor. Lipid droplets (LDs) have a pivotal role in promoting tumor metastasis. crosstalk mechanism between LDs and LNM modulated CC remains largely unknown.This study aimed to construct miRNA-dependent progonostic model investigate whether miR-532-5p has biological impact on by regualting accumulation.LASSO-Cox regression was applied establish prognostic prediction model. had the lowest P-value RNA...
The pathogenesis and developmental mechanism of early-stage (FIGO 2009 IA2-IIA2) cervical cancer (CC) remain unclear. Seeking novel molecular biomarkers based on Cancer Genome Atlas (TCGA) will facilitate the understanding CC help evaluate prognosis. To identify prognosis-related genes in CC, we analyzed TCGA mRNA-seq data clinical by univariate Cox Kaplan-Meier plotter analyses. Differential expression analysis identified upregulated CC. Combined with correlated unfavorable prognosis,...
Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding mechanism lymph will provide treatment strategies for CCa. Circular RNAs (circRNA) play a critical role development human cancers. However, and circRNAs remain largely unknown. Here, it reported that loss expression circRNA circVPRBP was closely associated LN poor survival CCa patients. In vitro vivo assays showed overexpression notably inhibited lymphangiogenesis...
Abstract Recognition of specific antigens expressed in cancer cells is the initial process cytolytic T cell‐mediated killing. However, this can be affected by other non‐cancerous cellular components tumor microenvironment. Here, it shown that interleukin‐33 (IL‐33)‐activated macrophages protect melanoma from tumor‐infiltrating lymphocyte‐mediated Mechanistically, IL‐33 markedly upregulates metalloprotease 9 (MMP‐9) expression macrophages, which acts as a sheddase to trim NKG2D, an activating...
Cervical cancer remains a significant health issue in developing countries. However, finding preclinical model that accurately reproduces tumor characteristics is challenging. Therefore, we established patient-derived organoids (PDOs) biobank containing 67 cases of heterogeneous cervical mimic the histopathological and genomic parental tumors. The vitro response indicated their ability to capture radiological heterogeneity patients. To individual responses adoptive T cell therapy (ACT),...
Abstract Cuproptosis is a novel form of regulated cell death triggered by copper ion and ionophore. While cuproptosis has been actively explored as potential target for cancer therapy, its role in ovarian (OC) still remains unclear. In this study, we demonstrate that inhibits OC proliferation, migration, invasion through FDX1 regulation suppresses tumor growth mouse model. We also confirm enhances sensitivity to cisplatin treatment both vivo vitro. Moreover, our findings reveal affects...
Background: Cervical cancer remains a leading cause of death in women due to metastasis distant tissues and organs. Integrins are involved metastasis. However, whether integrin α3 participates cervical is under investigation. In this study, we explored the effect detailed mechanism through which regulates cell migration, invasion, angiogenesis. Methods: Firstly, mRNA protein expression levels lines tissue samples obtained from patients. After knocking down using shRNA, proliferation,...
The prognosis for cervical cancer (CCa) patients with lymph node metastasis (LNM) is dismal. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies CCa LNM. However, precise mechanism in remains unclear. Herein, we demonstrated that protein tyrosine phosphatase receptor type M (PTPRM), identified from TCGA dataset, was markedly upregulated and correlated Moreover, PTPRM an independent prognostic factor multivariate Cox's proportional hazards model...
Cervical cancer remains a global health challenge. The identification of new immunotherapeutic targets may provide promising platform for advancing cervical treatment.
Endometrial cancer (EC) is one of the most common gynecological malignancies in women, accompanied by increasing incidence and decreasing age onset. Pyroptosis plays an important role occurrence development malignant tumors. However, relationship between pyroptosis-related genes tumor prognosis remains unclear. In this study, analyzing expression levels survival data 33 Cancer Genome Atlas (TCGA) normal samples samples, we obtained six prognostic differentially expressed (DEGs). Then,...
Defining reliable surrogate markers and overcoming drug resistance are the most challenging issues for improving therapeutic outcomes of antiangiogenic drugs (AADs) in cancer patients. At time this writing, no biomarkers clinically available to predict AAD benefits resistance. Here, we uncovered a unique mechanism epithelial carcinomas with KRAS mutations that targeted angiopoietin 2 (ANG2) circumvent antivascular endothelial growth factor (anti-VEGF) responses. Mechanistically, up-regulated...
To discover novel methylation-related differentially expressed genes (MRDEGs) for cervical cancer, with a focus on their potential early diagnosis and prognostic assessment.