A5051009448- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cleft Lip and Palate Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Reconstructive Facial Surgery Techniques
- Corneal surgery and disorders
- Cancer, Lipids, and Metabolism
- Nasal Surgery and Airway Studies
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Heat shock proteins research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Protease and Inhibitor Mechanisms
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Dermatologic Treatments and Research
Karolinska Institutet
2020-2025
Shenzhen University
2024-2025
Nanjing Medical University
2017-2025
Jiangsu Province Hospital
2025
Jilin Agricultural University
2025
Yunnan University of Traditional Chinese Medicine
2025
State Key Laboratory of Biotherapy
2024
Chongqing Medical University
2024
First Affiliated Hospital of Bengbu Medical College
2011-2024
Tianjin Medical University General Hospital
2024
Glucose uptake is essential for cancer glycolysis and involved in non-shivering thermogenesis of adipose tissues1-6. Most cancers use to harness energy their infinite growth, invasion metastasis2,7,8. Activation thermogenic metabolism brown tissue (BAT) by cold drugs instigates blood glucose adipocytes4,5,9. However, the functional effects global metabolic changes associated with BAT activation on tumour growth are unclear. Here we show that exposure tumour-bearing mice conditions markedly...
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of intertwined interactions between tumour stromal components in metastasis provide a new paradigm for PDAC therapy.
Abstract FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating + tumors are unavailable. Here we show that modulates tumor vessels by recruiting NG2 pricytes onto microvessels through a PDGFRβ-dependent mechanism. intrinsically resistant to clinically available targeting VEGF PDGF. Surprisingly, dual the PDGF signaling produces superior antitumor effect breast cancer fibrosarcoma models. Mechanistically, inhibition...
Apart from their killer identity, natural (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, present study revealed an interplay between NK and myeloid-derived suppressor (MDSCs) nonresponders of checkpoint therapy. Given that mechanisms governing outcome cell–to–myeloid cell interactions remain largely unknown, we sought to investigate cross-talk suppressive myeloid cells. Upon contact with tumor-experienced cells, monocytes neutrophils...
Abstract Accumulating evidence indicates that metabolic reprogramming of cancer cells supports the energy and demands during tumor metastasis. However, alterations underlying lymph node metastasis (LNM) cervical (CCa) have not been well recognized. In present study, it is found lymphatic metastatic CCa reduced dependency on glucose glycolysis but increased fatty acid oxidation (FAO). Inhibition carnitine palmitoyl transferase 1A (CPT1A) significantly compromises palmitate‐induced cell...
Abstract The circadian clock in animals and humans plays crucial roles multiple physiological processes. Disruption of homeostasis causes detrimental effects. Here, it is demonstrated that the disruption rhythm by genetic deletion mouse brain muscle ARNT‐like 1 (Bmal1) gene, coding for key transcription factor, augments an exacerbated fibrotic phenotype various tumors. Accretion cancer‐associated fibroblasts (CAFs), especially alpha smooth actin positive myoCAFs, accelerates tumor growth...
Melittin, a significant constituent of Apis mellifera (honeybee) venom, is water-soluble toxic peptide that has traditionally been used as an antitumor agent. However, the underlying mechanisms by which it inhibits tumor cell growth and angiogenesis remain to be elucidated. In present study, screening for increased cathepsin S (Cat S) expression levels was performed in MHCC97-H cells various other hepatocellular carcinoma lines reverse transcription-polymerase chain reaction western blot...
Accumulating evidence has suggested that microRNA-31-5p (miR-31-5p) is dysfunctional in hepatocellular carcinoma (HCC). However, the molecular mechanism of HCC remains unclear. In this study, we investigated role miR-31-5p tumor formation and development HCC. The expression was detected tissues, corresponding adjacent normal liver cell lines. mimics an inhibitor were transfected into HepG2 cells to assess effects on proliferation, apoptosis, cycle, migration, invasion assays. Western...
Significance The clinical efficacy of immunotherapy in cancer patients is limited. We have developed a zebrafish model that allows us to visualize the metastatic cell-killing effect by tumor-infiltrating lymphocytes and chimeric antigen receptor T cells vivo at single-cell level. This accurately predicts cell-mediated therapy. Our data provide an platform for validating antimetastatic effects human immunotherapy. Based on our findings, it highly recommended anticancer isolated from or...
Surgery can be used to remove tumors from patients with colon cancer, but some have recurrence a short time after the tumor is surgically removed, and disease-free survival (DFS) period short. Therefore, if these high-risk identified as early possible, appropriate treatment strategies formulated reduce their postoperative rate. Tumor immune scores been proven effective in predicting prognosis of patients, scoring only performed has removed patient. There still urgency find indicators that...
Abstract Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact global adipose tumor growth drug development by targeting remain largely unexplored. Here we show therapeutic paradigm drugs effective for treating various types browning tissues. Mirabegron, clinically available overactive bladders, displays potent anticancer effects animal models, including...
Small incision refractive lenticule extraction (SMILE) is an effective laser procedure that treats myopia. This research was to describe a novel approach treat corneal ulcer or perforation using the lenticules obtained from SMILE and evaluate safety effectiveness of tectonic keratoplasty with femtosecond intrastromal (TEKIL). A total twenty patients (22 eyes) were monitored for at least 6 months assessed slit lamp microscopy, optical coherence tomography, best-corrected visual acuity (BCVA)....
Abstract Recognition of specific antigens expressed in cancer cells is the initial process cytolytic T cell‐mediated killing. However, this can be affected by other non‐cancerous cellular components tumor microenvironment. Here, it shown that interleukin‐33 (IL‐33)‐activated macrophages protect melanoma from tumor‐infiltrating lymphocyte‐mediated Mechanistically, IL‐33 markedly upregulates metalloprotease 9 (MMP‐9) expression macrophages, which acts as a sheddase to trim NKG2D, an activating...
Cholangiocarcinoma is the second most common primary hepatobiliary malignancy with high incidence and recurrence rate. Ubiquitin-specific protease 8 (USP8) recently reported to be involved in tumor progression. Herein, we aimed investigate effects of USP8 on growth metastasis abilities cholangiocarcinoma cells.The siRNA interference was used knock down cell lines QBC939 RBE; Hucct-1 cells were transfected pcDNA3.1-USP8 up-regulate its expression. The detected by function assays. We analyzed...
Cervical cancer ranks fourth in women terms of incidence and mortality. The RNA-binding protein YTH N6-methyladenosine F2 (YTHDF2) contributes to progression by incompletely understood mechanisms. We show how YTHDF2 controls the fate cervical cells whether could be a valid target for therapy cancer. Sphere formation alkaline phosphatase staining assays were performed evaluate tumor stemness following knockdown. Apoptosis was detected flow cytometry TUNEL assay. compounds 4PBA SP600125 used...
The majority of studies regorafenib now were small-sample and single-arm, which potentially limits the strength evidence. We conduct study to identify efficacy safety for patients with metastatic colorectal cancer (mCRC) in real-world applications.