A5075059392- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Protein Structure and Dynamics
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
Singapore Immunology Network
2023-2025
Agency for Science, Technology and Research
2021-2025
Bioinformatics Institute
2021
Apart from their killer identity, natural (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, present study revealed an interplay between NK and myeloid-derived suppressor (MDSCs) nonresponders of checkpoint therapy. Given that mechanisms governing outcome cell–to–myeloid cell interactions remain largely unknown, we sought to investigate cross-talk suppressive myeloid cells. Upon contact with tumor-experienced cells, monocytes neutrophils...
While the pervasiveness of allostery in proteins is commonly accepted, we further show generic nature allosteric mechanisms by analyzing here transmembrane ion-channel viroporin 3a and RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2 along with metabolic enzymes isocitrate dehydrogenase 1 (IDH1) fumarate hydratase (FH) implicated cancers. Using previously developed structure-based statistical mechanical model (SBSMMA), share our experience signaling, predicting latent sites, inducing...
The functional plasticity of tumor-infiltrating B (TIL-B) cells spans from anti-tumor responses to non-canonical immune suppression. Yet, how tumor microenvironment (TME) influences TIL-B development is still underappreciated. Our current study integrated single cell transcriptomics and BCR (B receptor) sequencing profile phenotypes clonalities in hepatocellular carcinoma (HCC). Using trajectory gene regulatory network analysis, we were able characterize plasma cells, memory naïve within the...
<h3>Background</h3> Natural killer (NK) cells offer unique therapeutic potential given their antigen-independent cytotoxicity. NK cell dysfunction in hypoxic tumor microenvironments remains a barrier for therapies against solid tumors. Through single-cell RNA sequencing of primary head and neck squamous carcinomas, we identified CD103<sup>+</sup>CD49a<sup>+</sup> (termed ieILC1-like cells) that demonstrate upregulated expression effector molecules.<sup>1</sup> We developed novel method...