A5089213639- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Blood groups and transfusion
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Vascular anomalies and interventions
- Adrenal and Paraganglionic Tumors
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- MRI in cancer diagnosis
- Ferroptosis and cancer prognosis
- Acute Myeloid Leukemia Research
- Renal cell carcinoma treatment
- Congenital gastrointestinal and neural anomalies
- Advanced Proteomics Techniques and Applications
Singapore General Hospital
2018-2025
Duke-NUS Medical School
2022-2025
Atara Biotherapeutics (United States)
2025
Stanford Medicine
2024
Primary Source
2023
Stanford Health Care
2023
SingHealth
2023
Foundation Medicine (United States)
2019
Barts Health NHS Trust
2018
Imperial College London
2007-2015
Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a renowned pathogenic hallmark as well therapeutic target, we aimed investigate the prognostic clinico-pathological role of tissue markers hypoxia in GEP-NETs.Tissue microarray (TMA) blocks were constructed 86 diagnosed from 1988 2010. Tissue sections immunostained for inducible factor 1α (Hif-1α), vascular endothelial growth factor-A (VEGF-A),...
Abstract Objective Treatment efficacy of androgen deprivation therapy with radical prostatectomy for intermediate- to high-risk prostate cancer is less well-studied. The NEAR trial a single-arm, phase II investigation neoadjuvant apalutamide monotherapy and (RP) in the treatment D’Amico (NCT03124433). Materials methods Patients histologically-proven, adenocarcinoma received 240 mg once-daily 12 weeks followed by RP + /−lymphadenectomy. Primary outcome was pathological complete response (pCR)...
Abstract Background The optimal number of systematic biopsy cores in the era multi-parametric MRI targeted remains unclear, especially on its impact focal therapy planning. Our objective is to investigate reducing prostate cancer detection MRI-US fusion and as well relevance template planning for therapy. Materials methods A retrospective analysis 398 consecutive men who underwent both saturation (~24 cores) was performed. Four reduced-core strategies (two-thirds, half, one-third one-quarter...
Abstract Introduction We report herein the impact of focal therapy (FT) on multi‐domain functional outcomes in a Phase II prospective clinical trial (NCT04138914) cryotherapy for clinically significant prostate cancer (csPCa). Methods The primary outcome was detection ≥5 point deterioration any four main expanded index composite (EPIC) domains. Pretreatment multiparametric magnetic resonance imaging (mpMRI) and transperineal targeted systematic saturation biopsy were used to select patients...
The functional plasticity of tumor-infiltrating B (TIL-B) cells spans from anti-tumor responses to non-canonical immune suppression. Yet, how tumor microenvironment (TME) influences TIL-B development is still underappreciated. Our current study integrated single cell transcriptomics and BCR (B receptor) sequencing profile phenotypes clonalities in hepatocellular carcinoma (HCC). Using trajectory gene regulatory network analysis, we were able characterize plasma cells, memory naïve within the...
Prostate cancer is a leading cause of cancer-related mortality in men, highlighting the resistance to current treatments and need for new therapeutic options. PSMA (Prostate-Specific Membrane Antigen) overexpressed prostate tissues compared normal prostatic tissue, rendering it an ideal target therapies, enabling precise delivery agents cells. We evaluated expression 77 Chinese patients using immunohistochemistry (IHC), confirming its high malignant tissues. Due lack clinical activity from T...
Objective: This study aims to explore the integration of 5P Medicine (Predictive, Preventive, Personalized, Participatory, and Precision) within proactive healthcare model 3.0. By focusing on preventive strategies patient-centered approaches, it examines how advanced technologies, data analytics, personalized interventions can improve outcomes. Method: A comprehensive review literature current research Medicine, 3.0, their applications in was conducted. Key sources included peer-reviewed...
Introduction The Briganti 2019 nomogram stratifies risk of lymph node involvement (LNI) in prostate cancer, reducing unnecessary pelvic dissection (PLND) during radical prostatectomy (RP). However the applicability diverse populations remains under-explored, with only one external validation study performed an Asian population to date. We aim evaluate performance a large tertiary institution. Methods A retrospective cohort was conducted, analysis cancer registry our institution all patients...
ObjectivesMultiparametric magnetic resonance imaging (mpMRI) surveillance post focal cryotherapy (FT) of prostate cancer is challenging as treatment artefacts alter mpMRI findings. In this initial experience, we assessed diagnostic performance in detecting clinically significant (csPCa) after FT.Materials and methodsThis single-centre phase II prospective clinical trial recruited 28 men with localized csPCa for FT between October 2019 April 2021. 12-months were performed prior to biopsy...
Enterocolic lymphocytic phlebitis (ELP) is a recently described entity and of unknown etiology pathogenesis. It characterized by the bowel wall mesentery, without arterial involvement or evidence systemic vasculitis. The clinical presentation ELP varied, but it most commonly manifests with signs an acute abdomen. Clinical, radiologic, endoscopic findings are often conflicting misdiagnosis common as venous thrombosis not suspected. diagnosis obtained histologically. There spectrum histologic...
Chronic myelomonocytic leukaemia (CMML) is a clonal disorder with myelodysplastic/myeloproliferative features. Its diagnosis based on the presence of peripheral blood monocytosis and bone marrow aspirate findings, according to World Health Organization criteria. However, trephine biopsy (BMTB) features characteristic CMML have not been adequately investigated. We studied BMTB in 20 cases CMML-1 three CMML-2 compared ten polycythaemia vera, chronic myeloid (chronic phase) florid hyperplasia...
Objectives To evaluate the impact of intralesional heterogeneity on performance multiparametric magnetic resonance imaging (mpMRI) in determining cancer extent and treatment margins for focal therapy (FT) prostate cancer. Patients Methods We identified men who underwent primary radical prostatectomy organ‐ confined over a 3‐year period. Cancer foci whole‐mount histology were marked out, coding low‐grade (LG; Gleason 3) high‐grade (HG; 4–5) components separately. Measurements entire tumours...
CD45 is a transmembrane protein tyrosine phosphatase located on most haematopoietic cells. It has several isoforms, and cells express one or more of the isoforms—CD45RO, CD45RA CD45RB.1,2 immunoreactivity recognised to be highly specific for non–Hodgkin’s lymphomas.3,4 CD45-expressing non-haemopoietic tumours are very rare. This was first noted by McDonnell et al 5 in 1987, who reported primitive sarcoma expressing CD45. Subsequently, Nandedkar 6 three cases undifferentiated large-cell,...
Introduction: Rectal cancer response to neoadjuvant long-course chemoradiotherapy (LCCRT) is assessed by magnetic resonance tumour regression grade (mrTRG) and this has an impact on surgical management. However, there limited data the correlation between mrTRG pathological (pTRG). This study aims evaluate pTRG prognostic value of survival. Methods: Between 2011 2016, patients with rectal who underwent LCCRT had post-LCCRT MRI were included in study. Both dichotomised into good responders...
Peritoneal metastasis (PM), the regional progression of intra-abdominal malignancies, is a common sequelae colorectal cancer (CRC). Immunotherapy slated to be effective in generating long-lasting anti-tumour response as it utilizes specificity and memory immune system. In tumour microenvironment, associated macrophages (TAMs) are posited create an anti-inflammatory pro-tumorigenic environment. this paper, we aimed identify immunomodulatory factors with PM (CPM). A publicly available single...
Abstract Objective To evaluate if prostatic ductal adenocarcinoma (PDA) independently predicts poorer pathological and oncological outcomes after radical prostatectomy (RP). Methods Materials Utilizing a large prospective uro‐oncology registry, clinicopathological parameters of 1027 consecutive patients who underwent RP (2008–2017) were recorded. Oncological determined by failure to achieve unrecordable PSA postoperatively biochemical (BCF). Results PDA was present in 79 (7.7%) patients,...
There has been a rapid evolution in the treatment strategies for metastatic castration-resistant prostate cancer (mCRPC) following identification of targetable mutations, making genetic testing essential patient selection. Although several international guidelines recommend patients with mCRPC, there is lack locally endorsed clinical practice Singapore.