A5000828608- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Cardiac tumors and thrombi
- Electromagnetic Simulation and Numerical Methods
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Liver Diseases and Immunity
- Immune cells in cancer
Singapore General Hospital
2014-2025
Bladder cancer with loss of KDM6A expression is vulnerable to inhibition EZH2.
<h3>Objective</h3> Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought validate these findings, investigate how factors function promote GC, identify potential treatment GCs harbouring amplifications. <h3>Design</h3> <i>KLF5</i>, <i>GATA4</i> <i>GATA6</i> copy number gene expression was examined multiple GC cohorts....
<h3>Background</h3> GI stromal tumours (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. <h3>Objectives</h3> We sought to identify genetic alterations associated with high-risk GIST, explore their molecular consequences, and test utility as prognostic markers. <h3>Designs</h3> Exome sequencing 18 GISTs was performed (9 patients high-risk/metastatic 5 low/intermediate-risk), corresponding 11 primary 7 metastatic tumours. Candidate...
Abstract Soft tissue sarcomas (STS) are rare, heterogeneous tumors with poor survival outcomes, primarily due to reliance on cytotoxic chemotherapy and lack of targeted therapies. Given the uniquely individualized nature STS, we hypothesized that ex vivo drug sensitivity platform, quadratic phenotypic optimization platform (QPOP), can predict treatment response enhance combination therapy design for STS. Using QPOP, screened 45 primary STS patient samples, showed improved or concordant...
Abstract Introduction: The purpose of this study is to estimate the proportion oropharyngeal squamous cell carcinoma (OPSCC) attributable Human Papillomavirus (HPV) in Singapore across two different time periods (2008-2011 and 2018-2021). Experimental procedures: This non-interventional, cross-sectional involves retrospective analysis pre-treatment OPSCC tissue samples under General Hospital (SGH) after obtaining institutional ethics approval. Retrospective biobank records primary patients...
We investigate the molecular landscape of locally advanced nasopharyngeal carcinoma (LA-NPC) subtypes: limited (L), ascending (A), descending (D), and ascending-descending (AD). Using a cohort 994 patients, we perform germline somatic whole-exome sequencing (WES), transcriptomic profiling, multiplex immunohistochemistry (mIHC), spatial histopathological analyses tumor whole-slide images (WSIs). Germline WES reveals most variants in AD subtypes, but shows no subtype-specific mutations....
FIG 5. Multiplex immunohistochemistry/immunofluorescence applied to a section of the tumor showed various tumor-infiltrating immune cells: (A) CD3, (B) CD8, (C) CD68, (D) FOXP3, and (E) PD-L1.PD-L1-positive cells (19.7%) were also present.PD-L1, programmed death ligand-1.
Giant cells (GC) are a poorly understood subset of tumor that have been increasingly recognized as potential contributor to heterogeneity and treatment resistance. We aimed characterize the biological clinical significance GC in angiosarcoma, an aggressive rare cancer endothelial origin. Archival angiosarcoma samples were examined for presence compared with clinicopathological well NanoString gene expression data. cell lines MOLAS ISOHAS using conventional electron microscopy, single whole...
Peritoneal metastasis (PM), the regional progression of intra-abdominal malignancies, is a common sequelae colorectal cancer (CRC). Immunotherapy slated to be effective in generating long-lasting anti-tumour response as it utilizes specificity and memory immune system. In tumour microenvironment, associated macrophages (TAMs) are posited create an anti-inflammatory pro-tumorigenic environment. this paper, we aimed identify immunomodulatory factors with PM (CPM). A publicly available single...
Inflammasome is linked to many inflammatory diseases, including COVID-19 and autoimmune liver diseases. While severe was reported exacerbate failure, we report a fatal acute-on-chronic failure (ACLF) in stable primary biliary cholangitis-autoimmune hepatitis overlap syndrome patient triggered by mild infection. Postmortem biopsy showed sparse SARS-CoV-2-infected macrophages with extensive ASC (apoptosis-associated speck-like protein containing CARD) speck-positive hepatocytes, correlating...