A5037540355- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Nephrotoxicity and Medicinal Plants
- Epigenetics and DNA Methylation
- Innovations in Medical Education
- Reflective Practices in Education
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Education and Critical Thinking Development
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Drug-Induced Hepatotoxicity and Protection
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
National Cancer Centre Singapore
2013-2023
Duke-NUS Medical School
2010-2017
National University of Singapore
2010-2015
Genome Institute of Singapore
2010
Van Andel Institute
2010
Cancer Genetics (United States)
2010
Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver from Asia.
Bladder cancer with loss of KDM6A expression is vulnerable to inhibition EZH2.
Genetic alterations in kinases have been linked to multiple human pathologies. To explore the landscape of kinase genetic variation gastric cancer (GC), we used targeted, paired-end deep sequencing analyze 532 protein and phosphoinositide 14 GC cell lines. We identified 10,604 single-nucleotide variants (SNV) exons including greater than 300 novel nonsynonymous SNVs. Family-wise analysis SNVs revealed a significant enrichment mitogen-activated (MAPK)-related genes (P < 0.01), suggesting...
Abstract Clear cell renal carcinoma (ccRCC) constitutes 75% of all RCC. It is characterized by inactivation the tumor suppressor Von Hippel Lindau gene (VHL) in ~70% sporadic ccRCC cases. Recent large scale screen ~3,500 genes PCR-based exon re-sequencing identified several new cancer including UTX, JARID1C and SETD2. These encode enzymes that demethylate methylate key lysine residue histone H3. In particular, a 3 4 (H3K4) demethylase involved demethylation activating trimethyl H3K4...
Supplementary Figure 3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
Supplementary Figure 1 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
Supplementary Figure 2 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
Supplementary Methods and Materials, Results, Legends for Tables 1-11 Figures 1-3 from Genetic Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
Supplementary Figure 3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
Supplementary Methods and Materials, Results, Legends for Tables 1-11 Figures 1-3 from Genetic Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing