A5082369483- Sarcoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Tumors and Angiosarcomas
- Intraperitoneal and Appendiceal Malignancies
- Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Contraception
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Imaging and Diagnostics
- Diabetes Management and Research
- Ophthalmology and Visual Impairment Studies
- Maternal and Perinatal Health Interventions
- Bariatric Surgery and Outcomes
- Medical Imaging Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Health, psychology, and well-being
- Ocular Infections and Treatments
- Circular RNAs in diseases
- Uterine Myomas and Treatments
- Appendicitis Diagnosis and Management
- Poisoning and overdose treatments
- Child Nutrition and Feeding Issues
National University Hospital
2000-2024
National University Health System
2024
SingHealth
2020-2023
National Cancer Centre Singapore
2015-2023
Singapore General Hospital
2023
Instituto Nacional de Cancerología
2018
Odense University Hospital
2018
Singapore College of Traditional Chinese Medicine
2017
Siemens (Singapore)
2014
Khoo Teck Puat Hospital
2014
Abstract Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim investigate clinical significance these patients with soft tissue sarcoma (STS). Seven hundred and twelve available counts at diagnosis and/or metastatic relapse were retrospectively examined. An optimal cutoff for NLR-high (>2.5) predicting overall survival (OS) was determined using receiver operating curve analyses. Survival...
The aim of the study was to measure rest and stress myocardial blood flow (MBF) values prospectively in a low-risk population with 128-slice dual-source computed tomography (CT) compare MBF/coronary reserve (CFR) that second documented coronary artery disease (CAD).This evaluates resting hyperaemic MBF 35 individuals identified by modified Framingham Risk score calcium <100. patients were scanned using 80 kV quantitative generated complete time-attenuation curves. Global 74.08 ± 16.30 135.24...
Caesarean scar pregnancy is rare. A high index of suspicion necessary to make the right diagnosis early.Two women, each with a history 1 previous caesarean delivery, were initially diagnosed spontaneous abortion in progress when ultrasonography scan revealed gestational sac be lower uterine cavity. Subsequent ultrasound scans showed that was actually anterior wall at level isthmus.Both women managed successfully intrasac methotrexate injection.We report 2 cases pregnancies mistaken for...
Summary Background The status and determinants of health‐related quality life (HRQOL) in female veterans with without irritable bowel syndrome (IBS) are unknown. Aim To compare HRQOL IBS symptoms examine the contribution post‐traumatic stress disorder, depression anxiety to HRQOL. Methods A cross‐sectional study 339 veterans. Self‐report questionnaires were used evaluate symptoms, depression, Results Symptoms consistent present 33.5% participants. Female had significant reductions physical...
Abstract Background Ulceration of the oesophageal squamous mucosa (ulcerative oesophagitis) is a pathological manifestation gastro-oesophageal reflux disease, and major risk factor for development Barrett’s oesophagus. oesophagus characterised by replacement reflux-damaged epithelium with columnar intestinal-like epithelium. We previously reported discovery microRNAs that are differentially expressed between mucosa. Now, to better understand early steps in initiation oesophagus, we assessed...
This study aims to identify the demographics and hygiene behaviours associated with contact lens (CL)-related microbial keratitis in Singapore.The social of wearers presenting infectious Singapore were examined using an externally validated questionnaire. Fifty-eight consecutive who presented at National Eye Centre surveyed a self-administered Patients' demographics, CL-related behaviour, attitude aftercare visits results collected analysed.More than half (55%) patients female, average age...
Abstract Angiosarcomas are a rare subtype of soft-tissue sarcomas which exhibit aggressive clinical phenotypes with limited treatment options and poor outcomes. In this study, we investigated the relevance peripheral blood neutrophil-to-lymphocyte ratio (NLR) as marker systemic immune response, well its correlation intra-tumoral profiles in subgroup cases ( n = 35) using NanoString PanCancer IO360 panel multiplex immunohistochemistry. overall cohort 150), angiosarcomas head neck (AS-HN)...
Giant cells (GC) are a poorly understood subset of tumor that have been increasingly recognized as potential contributor to heterogeneity and treatment resistance. We aimed characterize the biological clinical significance GC in angiosarcoma, an aggressive rare cancer endothelial origin. Archival angiosarcoma samples were examined for presence compared with clinicopathological well NanoString gene expression data. cell lines MOLAS ISOHAS using conventional electron microscopy, single whole...
Abstract Objective: To determine if screening for undiagnosed type 2 diabetes mellitus (T2DM) and pre‐diabetes is feasible in an Australian ED; to estimate the prevalence of T2DM ED population. Methods: Prospective cross‐sectional survey St Vincent's Hospital, Melbourne, adult, tertiary referral centre seeing approximately 40 000 patients annually. A convenience sample adult was screened with finger‐prick random blood glucose glycosylated haemoglobin (HbA1c); those over 6.0 mmol/L 6.0% were...
Poisonings in children are common reasons for presentation to the emergency department and can potentially have serious complications. Our research aims review risk factors leading intentional self-poisoning.A retrospective medical record of all pediatric poisoning cases presenting Children's Emergency at National University Hospital, Singapore between January 2014 December 2015 was performed.Eighty-seven poisonings were identified, 31 (36.5%) which with suicidal intent. The majority female...
Plasmablastic lymphoma (PBL) is an aggressive subtype of mature B-cell non-Hodgkin lymphoma. Given its rarity, there remains a lack clinicopathological data to guide management, particularly on Asian patients.We conducted retrospective chart review 10 patients diagnosed with PBL at the National Cancer Centre Singapore and performed literature similar studies cohorts.Most were male (n = 9), median age diagnosis 55 years (range, 33 - 91 years). Seven (70%) considered be immunocompromised. In...
// Grace Fangmin Tan 1 and Jason Yongsheng Chan , 2 Division of Medical Oncology, National Cancer Centre Singapore, Singapore Oncology Academic Clinical Program, Duke-NUS School, Correspondence to: Chan, email: jason.chan.y.s@nccs.com.sg Keywords: rare cancer; single cell sequencing; chemoresistance; spatial transcriptomics Received: March 31, 2021 Accepted: June 10, Published: September 14, Copyright: © Chan. This is an open access article distributed under the terms Creative Commons...
Hodgkin’s lymphoma carries an excellent prognosis with modern chemotherapy, but a significant proportion of patients remain refractory to or relapse after first-line treatment. Immunological changes post-treatment, such as chemotherapy-induced neutropenia (CIN) lymphopenia, have shown prognostic significance in multiple tumor types. Our study aims investigate the value immunologic by examining post-treatment lymphocyte count (pALC), neutrophil (pANC) and neutrophil-lymphocyte ratio (pNLR)....
Women with gestational diabetes (GDM) have increased lifetime risk of developing diabetes. We aim to determine the factors contributing poor adherence postpartum oral glucose tolerance test (OGTT) and identify key predictors dysglycaemia in our Asian cohort.
In Brief Objective To determine whether cervical membrane sweeping (stripping) during induction of labor is beneficial. Methods We compared outcomes after in pregnant women at term a randomized trial. Women were assigned to having their membranes swept or not induction. Outcome measures included duration labor, maximum dose oxytocin used, induction-labor interval, and mode delivery. Results recruited 130 nulliparas (64 sweep, 66 non-sweep) 118 multiparas (60 58 nonsweep). Among who received...
Abstract Background: Laboratory markers of systemic inflammation have demonstrated utility and cost-effectiveness in the prediction clinical outcome various malignancies. The aim present study is to evaluate prognostic value neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) peritoneal carcinomatosis (PC) patients who undergone cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) a single institution. Methods: Data were prospectively collected from 164...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic associated with a spectrum of various renal and extrarenal manifestations, including increased risk cancers. Here, we present the initial molecular description sarcomatoid cell carcinoma (sRCC) arising in setting ADPKD. Methods Multiregion whole‐exome sequencing whole transcriptomic were used to examine intratumoral heterogeneity among histologically‐distinct spindle (sarcomatoid), epithelioid, or...
11049 Background: Recent studies suggest that markers of systemic inflammation such as blood neutrophil-to-lymphocyte ratio (NLR) may be prognostic for various cancers, though its clinical utility has not been widely accepted. This study aims to investigate relevance in patients (pts) with soft tissue sarcoma (STS). Methods: Five hundred and twenty-nine pts localized STS who had available pre-operative counts at the time diagnosis were retrospectively examined. An optimal cutoff high NLR (...
ObjectivesCRS and HIPEC is one of the treatment strategies that being employed for ovarian patients with peritoneal metastases (PM).However, despite careful patient selection complete macroscopic resection, early recurrences (ER) still occur.This study aims to identify risk factors ER in these patients. MethodsPatients PM treated CRS between January 2001 June 2016 at National Cancer Centre Singapore were analysed.Comparison who developed (<12 months) those late recurrence (>12 or no was...