A5031232719- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Radiopharmaceutical Chemistry and Applications
- Renal and related cancers
- Global Cancer Incidence and Screening
- Renal and Vascular Pathologies
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- Minimally Invasive Surgical Techniques
- Ethics in Clinical Research
- Cancer and Skin Lesions
Singapore General Hospital
2014-2025
Duke-NUS Medical School
2018-2025
SingHealth
2018-2024
National Cancer Centre Singapore
2024
Case Western Reserve University
2023
Peter MacCallum Cancer Centre
2022
SingHealth Duke-NUS Academic Medical Centre
2017-2021
National University of Singapore
2004-2021
Duke Medical Center
2015-2019
Duke Cancer Institute
2017-2019
To codify the use of multiparametric magnetic resonance imaging (mpMRI) for interrogation prostate neoplasia (PCa) in clinical practice and focal therapy (FT). An international collaborative consensus project was undertaken using Delphi method among experts field PCa. online questionnaire presented three consecutive rounds modified each round based on comments provided by experts. Subsequently, a face-to-face meeting held to discuss finalize results. mpMRI should be performed patients with...
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials Methods Ethics approval was obtained from centralized institutional review board for this prospective single-arm study, patients provided informed consent. Patients untreated low-volume low-grade (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm3) underwent MR-guided between July 2011...
Abstract Objective Treatment efficacy of androgen deprivation therapy with radical prostatectomy for intermediate- to high-risk prostate cancer is less well-studied. The NEAR trial a single-arm, phase II investigation neoadjuvant apalutamide monotherapy and (RP) in the treatment D’Amico (NCT03124433). Materials methods Patients histologically-proven, adenocarcinoma received 240 mg once-daily 12 weeks followed by RP + /−lymphadenectomy. Primary outcome was pathological complete response (pCR)...
Abstract Background The optimal number of systematic biopsy cores in the era multi-parametric MRI targeted remains unclear, especially on its impact focal therapy planning. Our objective is to investigate reducing prostate cancer detection MRI-US fusion and as well relevance template planning for therapy. Materials methods A retrospective analysis 398 consecutive men who underwent both saturation (~24 cores) was performed. Four reduced-core strategies (two-thirds, half, one-third one-quarter...
The purpose of this study is to investigate the accuracy multiparametric MRI with endorectal coil and Partin tables in predicting organ-confined (OC) prostate cancer a contemporary cohort undergoing radical prostatectomy (RP) assess possible added value radiologic staging based on predictive tables.One hundred fifty-eight consecutive subjects underwent 3-T before RP between November 2010 2013. Data were randomly split 60% 40% into derivation (n = 95) validation 62) datasets. Multiparametric...
To compare the oncologic and functional outcomes of partial vs whole-gland cryotherapy for men with intermediate-risk prostate cancer.Men cancer treated primary from 1993 to 2013 were selected Cryo On-Line Data Registry a 1:1 matched comparison between those undergoing (targeted ablation, unilateral/bilateral nerve-sparing ablations). A propensity score was developed based on age, prebiopsy serum prostate-specific antigen, biopsy Gleason score, clinical stage, volume, neoadjuvant androgen...
Abstract Introduction We report herein the impact of focal therapy (FT) on multi‐domain functional outcomes in a Phase II prospective clinical trial (NCT04138914) cryotherapy for clinically significant prostate cancer (csPCa). Methods The primary outcome was detection ≥5 point deterioration any four main expanded index composite (EPIC) domains. Pretreatment multiparametric magnetic resonance imaging (mpMRI) and transperineal targeted systematic saturation biopsy were used to select patients...
Treatment intensification with androgen deprivation therapy (ADT) and receptor pathway inhibitors (ARPi) have led to improved survival in advanced prostate cancer. However, ADT is linked significant cardiovascular toxicity, ARPi also negatively impacts health. Together a higher prevalence of baseline risk factors reported among cancer survivors at diagnosis, there pressing need prioritise optimise health this population. Firstly, While no dedicated toxicity calculators are available, other...