A5031506572- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Urinary Bladder and Prostate Research
- Colorectal Cancer Surgical Treatments
- Genital Health and Disease
- Advanced Radiotherapy Techniques
- Molecular Biology Techniques and Applications
- Minimally Invasive Surgical Techniques
- Colorectal Cancer Screening and Detection
- Urinary Tract Infections Management
- Statistical Methods in Clinical Trials
- Pelvic floor disorders treatments
- Male Reproductive Health Studies
- Global Cancer Incidence and Screening
University of Michigan
2016-2025
Johns Hopkins University
2023-2025
Michigan Medicine
2018-2024
Johns Hopkins Medicine
2023-2024
VA Ann Arbor Healthcare System
2017-2024
Brigham and Women's Hospital
2022
Harvard University
2022
University College London Hospitals NHS Foundation Trust
2022
University College London
2022
University Medical Center Hamburg-Eppendorf
2022
Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect cancer. The implications of targeted alone vs standard extended-sextant or the 2 modalities combined are not well understood.To assess and approaches for diagnosis intermediate- high-risk cancer.Prospective cohort study 1003 men undergoing both concurrently from 2007 through 2014 at National Cancer Institute in United States. Patients were referred elevated level prostate-specific antigen (PSA)...
Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been particular interest for biomedical applications. The ability such convert absorbed near-infrared heat and induce highly localized hyperthermia has shown be effective photothermal cancer therapy, resulting in cell death tumor remission a multitude preclinical animal models. Here we report the initial results clinical trial which laser-excited gold-silica nanoshells (GSNs) were used...
To evaluate accuracy and interobserver variability with the use of Prostate Imaging Reporting Data System (PI-RADS) version 2.0 for detection prostate cancer at multiparametric magnetic resonance (MR) imaging in a biopsy-naïve patient population.This retrospective HIPAA-compliant study was approved by local ethics committee, written informed consent obtained from all patients their histopathologic data future research studies. In 101 elevated prostate-specific antigen levels who underwent MR...
Purpose To characterize clinically important prostate cancers missed at multiparametric (MP) magnetic resonance (MR) imaging. Materials and Methods The local institutional review board approved this HIPAA-compliant retrospective single-center study, which included 100 consecutive patients who had undergone MP MR imaging subsequent radical prostatectomy. A genitourinary pathologist blinded to findings outlined on whole-mount pathology slices. Two readers correlated mapped lesions with reports...
Purpose Multiparametric MRI (mpMRI) improves the detection of clinically significant prostate cancer, but is limited by interobserver variation. The second version theProstate Imaging Reporting and Data System (PIRADSv2) was recently proposed as a standard for interpreting mpMRI. To assess performance agreement PIRADSv2 we performed multi-reader study with five radiologists varying experience. Materials Methods Five (n = 2 dedicated, n 3 general body) blinded to clinicopathologic results...
Focal therapy (FT) is emerging as an alternative to radical treatment for prostate cancer (CaP). The purpose of this study assess the current perceptions FT amongst urologists. A 22-item questionnaire was e-mailed members American Urological Association. Multivariate logistic regression analysis used identify predictors utilization. Results were compared a previous survey from 2019. Two hundred and sixty-four responses recorded. Less than half (115/264, 43.6%) respondents utilize FT; among...
Given the limitations of prostate specific antigen and standard biopsies for detecting cancer, we evaluated cancer detection rate external validity a magnetic resonance imaging/transrectal ultrasound fusion guided biopsy system used at National Institutes Health.We performed phase III trial with participants enrolled between 2012 2013. A total 153 men consented to study underwent 3 Tesla multiparametric imaging an endorectal coil clinical suspicion cancer. Lesions were classified as low or...
No AccessJournal of UrologyAdult Urology1 Aug 2016Positive Surgical Margins Increase Risk Recurrence after Partial Nephrectomy for High Renal Tumors Paras H. Shah, Daniel M. Moreira, Zhamshid Okhunov, Vinay R. Patel, Sameer Chopra, Aria A. Razmaria, Manaf Alom, Arvin K. George, Oksana Yaskiv, Michael J. Schwartz, Mihir Desai, Manish Vira, Lee Richstone, Jaime Landman, Arieh L. Shalhav, Inderbir Gill, and Louis Kavoussi ShahParas Shah Department Urology, Smith Institute North Shore LIJ, New...
The centrality-index (C-Index), preoperative aspects and dimensions used for anatomic (P.A.D.U.A.) classification, radius.exophyic/endophytic.nearness.anterior/posterior.location (R.E.N.A.L.) nephrometry schemes were developed as standardized scoring systems (SS) to quantify characteristics of kidney tumors. objective this study was establish reliability assess relationships between these three SS perioperative postoperative variables.A retrospective chart review performed in 101 patients...
Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) was developed to standardize the interpretation reporting of multiparametric prostate magnetic resonance imaging provide guidelines for biopsy findings. We prospectively evaluated cancer detection rate at each overall PI-RADSv2 score.This prospective study included 62 consecutive patients with 116 lesions who underwent 3T evaluation subsequent targeted imaging/transrectal ultrasound fusion guided concurrent 12-core systematic...
No AccessJournal of UrologyAdult Urology1 Feb 2017Missing the Mark: Prostate Cancer Upgrading by Systematic Biopsy over Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Akhil Muthigi, Arvin K. George, Abhinav Sidana, Michael Kongnyuy, Richard Simon, Vanessa Moreno, Maria J. Merino, Peter L. Choyke, Baris Turkbey, Bradford Wood, and A. Pinto MuthigiAkhil Muthigi Urologic Oncology Branch, National Institute, Institutes Health, Bethesda, Maryland , GeorgeArvin George Department Urology,...
No AccessJournal of UrologyAdult Urology1 Mar 2017Magnetic Resonance Imaging-Transrectal Ultrasound Guided Fusion Biopsy to Detect Progression in Patients with Existing Lesions on Active Surveillance for Low and Intermediate Risk Prostate Cancer Thomas P. Frye, Arvin K. George, Amichai Kilchevsky, Mahir Maruf, M. Minhaj Siddiqui, Michael Kongnyuy, Akhil Muthigi, Hui Han, Howard L. Parnes, Maria Merino, Peter Choyke, Baris Turkbey, Brad Wood, A. Pinto FryeThomas Frye More articles by this...
Importance High-resolution microultrasonography-guided biopsy is an alternative to MRI fusion-guided for prostate cancer diagnosis. Objective To compare and biopsy. Design, Setting, Participants A multicenter, international, open-label, randomized, noninferiority trial of biopsy-naive men from 20 centers (8 countries) with clinical suspicion (elevated prostate-specific antigen [PSA] and/or abnormal digital rectal examination findings) December 2021 September 2024. Interventions were assigned...
To codify the use of multiparametric magnetic resonance imaging (mpMRI) for interrogation prostate neoplasia (PCa) in clinical practice and focal therapy (FT). An international collaborative consensus project was undertaken using Delphi method among experts field PCa. online questionnaire presented three consecutive rounds modified each round based on comments provided by experts. Subsequently, a face-to-face meeting held to discuss finalize results. mpMRI should be performed patients with...
Background: Use of magnetic resonance (MR) imaging to improve prostate biopsy efficiency is rapidly gaining in popularity. The aim this study was assess the MR/ultrasound (MR/US) fusion-guided ("targeted") biopsies vs extended-sextant 12-core ("standard") for overall and high-grade cancer detection.
We studied recurrence-free survival after partial vs radical nephrectomy for clinical stage T1 renal cell carcinoma in all patients and those up staged to pathological T3a.We retrospectively reviewed the records of 1,250 who underwent or clinically localized between 2006 2014. Recurrence-free was estimated using Kaplan-Meier method evaluated as a function type with log rank test Cox models, adjusting clinical, radiological characteristics.A total 86 recurrences (7%) were observed during...