A5068192998- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Ureteral procedures and complications
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Sexual function and dysfunction studies
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Minimally Invasive Surgical Techniques
- Pediatric Urology and Nephrology Studies
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Genital Health and Disease
- Healthcare Systems and Public Health
- Opioid Use Disorder Treatment
- MRI in cancer diagnosis
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2004-2024
University of Baltimore
2010-2023
Urological Society of Australia and New Zealand
2020-2023
Johns Hopkins Hospital
2017-2023
Brady (Norway)
2023
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genodermatosis characterized by the development of small dome-shaped papules on face, neck, and upper trunk (fibrofolliculomas). In addition to these benign hair follicle tumors, BHD confers increased risk renal neoplasia spontaneous pneumothorax. To date, there has been no systematic pathologic analysis tumors associated with this syndrome. We reviewed 130 solid resected from 30 patients in 19 different families. Preoperative computed...
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
PURPOSE Resection of solitary metastases from renal cell carcinoma (RCC) is associated with a 5-year survival rate 35% to 50%. Selection criteria are not well defined. PATIENTS AND METHODS We retrospectively analyzed our experience 278 patients recurrent RCC 1980 1993. RESULTS One hundred forty-one underwent curative metastectomy for their first recurrence (44% overall [OS] rate), 70 noncurative surgery (14% OS and 67 were treated nonsurgically (11% rate). Favorable features disease-free...
We previously demonstrated the ability to detect metastatic prostate cancer using <i>N</i>-[<i>N</i>-[(<i>S</i>)-1,3-dicarboxypropyl]carbamoyl]-4-<sup>18</sup>F-fluorobenzyl-l-cysteine (<sup>18</sup>F-DCFBC), a low-molecular-weight radiotracer that targets prostate-specific membrane antigen (PSMA). PSMA has been shown be associated with higher Gleason grade and more aggressive disease. An imaging biomarker able clinically significant high-grade primary reliably would address an unmet...
Thermal tissue ablation with radio frequency energy is an experimental treatment of renal tumor. We report early results ongoing trial percutaneous for small tumors.Patients percutaneously accessible tumors were evaluated ablation. Tumors solid on computerized tomography (CT), 3 cm. or less in diameter and enlarging during at least 1 year. Ablation was performed the Interventional Radiology suite under ultrasound and/or CT guidance. A 50 W., 460 kHz. electrosurgical generator delivered via a...
No AccessJournal of UrologyAdult Urology: Oncology: Renal/Upper Tract/Bladder1 May 2005EVALUATION AND MANAGEMENT OF RENAL TUMORS IN THE BIRT-HOGG-DUBÉ SYNDROMEis corrected byERRATA CHRISTIAN P. PAVLOVICH, ROBERT L. GRUBB, KATHLEEN HURLEY, GLADYS M. GLENN, JORGE TORO, LAURA S. SCHMIDT, CARLOS TORRES-CABALA, MARIA J. MERINO, BERTON ZBAR, PETER CHOYKE, McCLELLAN WALTHER, and W. MARSTON LINEHAN PAVLOVICHCHRISTIAN PAVLOVICH , GRUBBROBERT GRUBB HURLEYKATHLEEN HURLEY GLENNGLADYS GLENN TOROJORGE...
We establish whether a subset of infertile men have decreased serum testosterone-to-estradiol ratios and this condition can be corrected with an oral aromatase inhibitor.The 63 severe male factor infertility or hypergonadotropic hypogonadism (mean follicle-stimulating hormone 21.2 +/- 1.8) were compared those age matched, fertile, control reference group. Of the 43 azoospermic biopsy proved 20 oligospermic. The lowest (less than 20th percentile) treated 50 to 100 mg inhibitor testolactone...
We assessed the complications associated with urological laparoscopic surgery at a single high volume center during 12-year period.A retrospective chart analysis was performed, focusing on 2,775 surgeries occurring between 1993 and 2005. These included radical nephrectomy (549), partial (345), donor (553), simple (186), pyeloplasty (301), nephroureterectomy (105), retroperitoneal lymph node dissection (86), renal ablation (81), adrenalectomy (106) prostatectomy (463). Complication data were...
The Birt-Hogg-Dubé (BHD) syndrome is an inherited genodermatosis characterized by a predisposition to hamartomatous skin lesions, pulmonary cysts, and renal carcinoma. Seventy-seven tumors from 12 patients with germline BHD mutations were examined DNA sequencing identify somatic in the second copy of BHD. Sequence alterations detected majority (41 77, 53%), loss heterozygosity at locus minority additional (14 17%). distributed across entire gene, resulted frameshifts that are predicted...
We determined whether serial prostate needle biopsies predispose men to erectile dysfunction and/or lower urinary tract symptoms over time.Men with cancer on an active surveillance protocol were administered the 5-item Sexual Health Inventory for Men and International Prostate Symptom Score questionnaires entry, at a cross-sectional point in 2008. All had least 1, 10 12-core biopsy entry yearly thereafter recommended.Of 333 231 returned followup questionnaires. Correlations found between...
No AccessJournal of UrologyAdult Urology1 Dec 2010The Learning Curve for Laparoscopic Radical Prostatectomy: An International Multicenter Study Fernando P. Secin, Caroline Savage, Claude Abbou, Alexandre de La Taille, Laurent Salomon, Jens Rassweiler, Marcel Hruza, François Rozet, Xavier Cathelineau, Gunther Janetschek, Faissal Nassar, Ingolf Turk, Alex J. Vanni, Inderbir S. Gill, Philippe Koenig, Jihad H. Kaouk, Luis Martinez Pineiro, Vito Pansadoro, Paolo Emiliozzi, Anders Bjartell, Thomas...
Conventional ultrasound systems operate at 6 to 9 MHz and serve as the standard of care guide prostate biopsies. We present a protocol using novel high resolution (29 MHz) transrectal micro-ultrasound system. This includes scoring system assess risk prostatic carcinoma enable real-time targeted biopsies.The ExactVu™ is currently being used in multisite, 2,000-patient, randomized clinical trial. Cine loops 400 biopsies from this trial were create PRI-MUS™ (prostate identification...
Understanding the degree of phenotypic heterogeneity in a small renal mass may have implications for interpreting biopsy data. In this study we quantify nuclear grade masses.Our institutional database was queried patients with T1a (less than 4 cm) masses stratified by criteria imaging diameter less 2 cm or greater, clear cell papillary histology, low (Fuhrman 1-2) high 3-4) tissue available review. Four consecutive specimens were chosen from each 8 strata total 32. All reanalyzed and highest...
To update the Partin Tables for prediction of pathological stage in contemporary setting and examine trends patients treated with radical prostatectomy (RP) over past three decades.From January 2010 to October 2015, 4459 men meeting inclusion criteria underwent RP pelvic lymphadenectomy histologically confirmed prostate cancer at Johns Hopkins Hospital. Preoperative clinical stage, serum prostate-specific antigen (PSA) level, biopsy Gleason score (i.e. prognostic Grade Group) were used a...
Importance High-resolution microultrasonography-guided biopsy is an alternative to MRI fusion-guided for prostate cancer diagnosis. Objective To compare and biopsy. Design, Setting, Participants A multicenter, international, open-label, randomized, noninferiority trial of biopsy-naive men from 20 centers (8 countries) with clinical suspicion (elevated prostate-specific antigen [PSA] and/or abnormal digital rectal examination findings) December 2021 September 2024. Interventions were assigned...